Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses

A variety of isosteres of the DNA polymerase inhibitor aphidicolin were synthesized as potential antiherpes agents. Modeling studies indicated that the bicyclooctane C, D rings of aphidicolin could be replaced by an aromatic moiety while maintaining the spatial arrangement of the hydroxyl group equi...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-11, Vol.36 (23), p.3503-3510
Hauptverfasser:	Selwood, David L, Challand, S. Richard, Champness, John N, Gillam, Janet, Hibberd, Deborah K, Jandu, K. Singh, Lowe, Denise, Pether, Michael, Selway, John, Trantor, George E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Aphidicolin - analogs & derivatives Aphidicolin - chemistry Aphidicolin - pharmacology Binding Sites Crystallography, X-Ray Cytomegalovirus - drug effects Cytomegalovirus - enzymology Deoxycytosine Nucleotides - metabolism Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - enzymology Models, Molecular Molecular Structure Nucleic Acid Synthesis Inhibitors Phenanthrenes - chemical synthesis Phenanthrenes - chemistry Phenanthrenes - pharmacology Stereoisomerism Structure-Activity Relationship
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