Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

Nuclear factor of activated T cells (NFAT) is a transcription factor that regulates expression of the cytokine interleukin-2 (IL-2) in activated T cells. The DNA-binding specificity of NFAT is conferred by NFATp, a phosphoprotein that is a target for the immunosuppressive compounds cyclosporin A and...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-10, Vol.262 (5134), p.750-754
Hauptverfasser:	McCaffrey, Patricia G., Luo, Chun, Kerppola, Tom K., Jain, Jugnu, Badalian, Tina M., Ho, Andrew M., Burgeon, Emmanuel, Lane, William S., Lambert, John N., Curran, Tom, Verdine, Gregory L., Rao, Anjana, Hogan, Patrick G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Antiserum Base Sequence Biological and medical sciences Cell Line Complementary DNA DNA DNA, Complementary DNA-Binding Proteins - genetics DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Gels Immunosuppressive Agents - pharmacology Interleukin-2 - genetics Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data NFATC Transcription Factors Nuclear Proteins Oligonucleotides Phosphoproteins - genetics Phosphoproteins - isolation & purification Phosphoproteins - physiology Promoter Regions, Genetic Proto-Oncogene Proteins c-fos - physiology Proto-Oncogene Proteins c-jun - physiology Recombinant Proteins RNA, Messenger - analysis T lymphocytes T-Lymphocytes - chemistry Transcription factors Transcription Factors - genetics Transcription Factors - isolation & purification Transcription Factors - physiology Transcription. Transcription factor. Splicing. Rna processing
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