Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted
We have examined the long arm of chromosome 17 in sporadic breast carcinomas for the loss of heterozygosity (LOH) at 18 polymorphic loci. At least three distinct regions could be identified by the frequency of LOH and confirmed by high density deletion maps of individual tumor DNAs. A proximal regio...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1993-12, Vol.53 (23), p.5617-5619 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | CROPP, C. S CHAMPEME, M.-H LIDEREAU, R CALLAHAN, R |
| description | We have examined the long arm of chromosome 17 in sporadic breast carcinomas for the loss of heterozygosity (LOH) at 18 polymorphic loci. At least three distinct regions could be identified by the frequency of LOH and confirmed by high density deletion maps of individual tumor DNAs. A proximal region affected by LOH is located in a 22-cM region defined by D17S73 and NME1 and thus is similar in location to the region thought to contain the BRCA1 gene associated with familial breast and breast/ovarian cancer. The central region affected by LOH is bordered by the D17S86 and D17S21 loci and is estimated to be 28 cM in size. The third region is bordered by the D17S20 and D17S77 loci which are 11 cM apart. These results define three independent regions of chromosome 17q which are likely to contain tumor suppressor genes relevant to the etiology of sporadic breast carcinoma. |
| format | Article |
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S ; CHAMPEME, M.-H ; LIDEREAU, R ; CALLAHAN, R</creator><creatorcontrib>CROPP, C. S ; CHAMPEME, M.-H ; LIDEREAU, R ; CALLAHAN, R</creatorcontrib><description>We have examined the long arm of chromosome 17 in sporadic breast carcinomas for the loss of heterozygosity (LOH) at 18 polymorphic loci. At least three distinct regions could be identified by the frequency of LOH and confirmed by high density deletion maps of individual tumor DNAs. A proximal region affected by LOH is located in a 22-cM region defined by D17S73 and NME1 and thus is similar in location to the region thought to contain the BRCA1 gene associated with familial breast and breast/ovarian cancer. The central region affected by LOH is bordered by the D17S86 and D17S21 loci and is estimated to be 28 cM in size. The third region is bordered by the D17S20 and D17S77 loci which are 11 cM apart. These results define three independent regions of chromosome 17q which are likely to contain tumor suppressor genes relevant to the etiology of sporadic breast carcinoma.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8242614</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; breast ; Breast Neoplasms - genetics ; carcinoma ; chromosome 17 ; Chromosome Deletion ; Chromosomes, Human, Pair 17 ; deletion ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; man ; Medical sciences ; Restriction Mapping ; tumor suppressor genes ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 1993-12, Vol.53 (23), p.5617-5619</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3825632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8242614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CROPP, C. S</creatorcontrib><creatorcontrib>CHAMPEME, M.-H</creatorcontrib><creatorcontrib>LIDEREAU, R</creatorcontrib><creatorcontrib>CALLAHAN, R</creatorcontrib><title>Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>We have examined the long arm of chromosome 17 in sporadic breast carcinomas for the loss of heterozygosity (LOH) at 18 polymorphic loci. At least three distinct regions could be identified by the frequency of LOH and confirmed by high density deletion maps of individual tumor DNAs. A proximal region affected by LOH is located in a 22-cM region defined by D17S73 and NME1 and thus is similar in location to the region thought to contain the BRCA1 gene associated with familial breast and breast/ovarian cancer. The central region affected by LOH is bordered by the D17S86 and D17S21 loci and is estimated to be 28 cM in size. The third region is bordered by the D17S20 and D17S77 loci which are 11 cM apart. These results define three independent regions of chromosome 17q which are likely to contain tumor suppressor genes relevant to the etiology of sporadic breast carcinoma.</description><subject>Biological and medical sciences</subject><subject>breast</subject><subject>Breast Neoplasms - genetics</subject><subject>carcinoma</subject><subject>chromosome 17</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, Pair 17</subject><subject>deletion</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>man</subject><subject>Medical sciences</subject><subject>Restriction Mapping</subject><subject>tumor suppressor genes</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYso67r6Jwg5iLdC0nz2KIsfCwte9LxM0omNtM1u0iL-9xYsXj0Nb96Pmcc7K9ZMclNqIeR5saaUmlIKXV0WVzl_zlIyKlfFylSiUkysi9OuwWEMPjgYQxxI9GRsEyJJ-DHrTOada1PsY449EqZPJAzkmEIP6Zu0Uw8DsQkhj8RBcmGIPWTy1QbXEkhIfMLTNH_ovkmDHY7YXBcXHrqMN8vcFO9Pj2_bl3L_-rzbPuzLtmJyLL2yVvHaC-MAGmERTF0rzbhjqhaGC2mpt1rbygtGda1QMOSIUDstLDd8U9z_3j2mOEfI46EP2WHXwYBxygetqNZc839BpoyuDZUzeLuAk-2xOSwtHJYyZ_9u8SE76HyCwYX8h3FTScUr_gPdb39j</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>CROPP, C. S</creator><creator>CHAMPEME, M.-H</creator><creator>LIDEREAU, R</creator><creator>CALLAHAN, R</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T3</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted</title><author>CROPP, C. S ; CHAMPEME, M.-H ; LIDEREAU, R ; CALLAHAN, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h215t-f6bb639f48caad4bea8996713c16948345b0fb77b2f410796e41e3eea9c74b383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>breast</topic><topic>Breast Neoplasms - genetics</topic><topic>carcinoma</topic><topic>chromosome 17</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Human, Pair 17</topic><topic>deletion</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>man</topic><topic>Medical sciences</topic><topic>Restriction Mapping</topic><topic>tumor suppressor genes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CROPP, C. S</creatorcontrib><creatorcontrib>CHAMPEME, M.-H</creatorcontrib><creatorcontrib>LIDEREAU, R</creatorcontrib><creatorcontrib>CALLAHAN, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Human Genome Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CROPP, C. S</au><au>CHAMPEME, M.-H</au><au>LIDEREAU, R</au><au>CALLAHAN, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>53</volume><issue>23</issue><spage>5617</spage><epage>5619</epage><pages>5617-5619</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>We have examined the long arm of chromosome 17 in sporadic breast carcinomas for the loss of heterozygosity (LOH) at 18 polymorphic loci. At least three distinct regions could be identified by the frequency of LOH and confirmed by high density deletion maps of individual tumor DNAs. A proximal region affected by LOH is located in a 22-cM region defined by D17S73 and NME1 and thus is similar in location to the region thought to contain the BRCA1 gene associated with familial breast and breast/ovarian cancer. The central region affected by LOH is bordered by the D17S86 and D17S21 loci and is estimated to be 28 cM in size. The third region is bordered by the D17S20 and D17S77 loci which are 11 cM apart. These results define three independent regions of chromosome 17q which are likely to contain tumor suppressor genes relevant to the etiology of sporadic breast carcinoma.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8242614</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1993-12, Vol.53 (23), p.5617-5619 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Biological and medical sciences breast Breast Neoplasms - genetics carcinoma chromosome 17 Chromosome Deletion Chromosomes, Human, Pair 17 deletion Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases man Medical sciences Restriction Mapping tumor suppressor genes Tumors |
| title | Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted |
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