Carcinoma of the breast with stromal multinucleated giant cells
Three cases of invasive mammary carcinoma with stromal osteoclast‐like giant cells are reported. All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens sh...
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| Veröffentlicht in: | Histopathology 1985-02, Vol.9 (2), p.183-193 |
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| container_title | Histopathology |
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| creator | NIELSEN, B.B. KIAER, H.W. |
| description | Three cases of invasive mammary carcinoma with stromal osteoclast‐like giant cells are reported. All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens showed numerous osteoclast‐like giant cells, vascular proliferation, and accumulation of haemosiderin pigment. Supplementary immunohistochemical and electron microscopical investigations indicated that the giant cells originated from mononuclear stromal cells with only slight histiocytic properties. The giant cell formation was probably induced by the infiltrating carcinomatous tissue which is also believed to induce new blood vessel formation. However, there is no evidence of a direct relationship between these features. |
| doi_str_mv | 10.1111/j.1365-2559.1985.tb02434.x |
| format | Article |
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All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens showed numerous osteoclast‐like giant cells, vascular proliferation, and accumulation of haemosiderin pigment. Supplementary immunohistochemical and electron microscopical investigations indicated that the giant cells originated from mononuclear stromal cells with only slight histiocytic properties. The giant cell formation was probably induced by the infiltrating carcinomatous tissue which is also believed to induce new blood vessel formation. However, there is no evidence of a direct relationship between these features.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.1985.tb02434.x</identifier><identifier>PMID: 2985488</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma, Mucinous - pathology ; Aged ; breast ; Breast Neoplasms - pathology ; carcinoma ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Cell Nucleus - pathology ; Female ; giant cell ; Humans ; Immunochemistry ; Microscopy, Electron ; Middle Aged ; origin ; stroma</subject><ispartof>Histopathology, 1985-02, Vol.9 (2), p.183-193</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4363-4d056819734484b5d2ed4c6cea8a5a651ea97e0cdd184ce79d4c971acd12c9393</citedby><cites>FETCH-LOGICAL-c4363-4d056819734484b5d2ed4c6cea8a5a651ea97e0cdd184ce79d4c971acd12c9393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.1985.tb02434.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.1985.tb02434.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2985488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NIELSEN, B.B.</creatorcontrib><creatorcontrib>KIAER, H.W.</creatorcontrib><title>Carcinoma of the breast with stromal multinucleated giant cells</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Three cases of invasive mammary carcinoma with stromal osteoclast‐like giant cells are reported. All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens showed numerous osteoclast‐like giant cells, vascular proliferation, and accumulation of haemosiderin pigment. Supplementary immunohistochemical and electron microscopical investigations indicated that the giant cells originated from mononuclear stromal cells with only slight histiocytic properties. The giant cell formation was probably induced by the infiltrating carcinomatous tissue which is also believed to induce new blood vessel formation. However, there is no evidence of a direct relationship between these features.</description><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Aged</subject><subject>breast</subject><subject>Breast Neoplasms - pathology</subject><subject>carcinoma</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Cell Nucleus - pathology</subject><subject>Female</subject><subject>giant cell</subject><subject>Humans</subject><subject>Immunochemistry</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>origin</subject><subject>stroma</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS0EglL4BKSIBbsEvx2zAKGKRyUESDx3lutMISVpiu2I8vckatU9s_Hizj1jHYSOCc5IN6ezjDApUiqEzojORRYnmHLGs-UWGmyibTTADOsUE6n20H4IM4yJYpTuol3atXieD9DFyHpXzpvaJs00iZ-QTDzYEJOfMn4mIfouqZK6rWI5b10FNkKRfJR2HhMHVRUO0M7UVgEO1-8QvVxfPY9u07uHm_Ho8i51nEmW8gILmROtGOc5n4iCQsGddGBzK6wUBKxWgF1RkJw7ULpLtSLWFYQ6zTQbopMVd-Gb7xZCNHUZ-h_YOTRtMEpixTRV3eLZatH5JgQPU7PwZW39ryHY9PbMzPSKTK_I9PbM2p5ZduWj9ZV2UkOxqa51dfn5Kv8pK_j9B9ncjp9IzjpAugKUIcJyA7D-y0jFlDBv9zfmUdFXMnqXhrI_VAqOcg</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>NIELSEN, B.B.</creator><creator>KIAER, H.W.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Carcinoma of the breast with stromal multinucleated giant cells</title><author>NIELSEN, B.B. ; KIAER, H.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-4d056819734484b5d2ed4c6cea8a5a651ea97e0cdd184ce79d4c971acd12c9393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Aged</topic><topic>breast</topic><topic>Breast Neoplasms - pathology</topic><topic>carcinoma</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Cell Nucleus - pathology</topic><topic>Female</topic><topic>giant cell</topic><topic>Humans</topic><topic>Immunochemistry</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>origin</topic><topic>stroma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NIELSEN, B.B.</creatorcontrib><creatorcontrib>KIAER, H.W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NIELSEN, B.B.</au><au>KIAER, H.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinoma of the breast with stromal multinucleated giant cells</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>1985-02</date><risdate>1985</risdate><volume>9</volume><issue>2</issue><spage>183</spage><epage>193</epage><pages>183-193</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Three cases of invasive mammary carcinoma with stromal osteoclast‐like giant cells are reported. All the specimens were grossly of reddish‐brown colour. On microscopical examination two were invasive ductal carcinomas and the third was of mixed ductal. and mucoid type. In the stroma all specimens showed numerous osteoclast‐like giant cells, vascular proliferation, and accumulation of haemosiderin pigment. Supplementary immunohistochemical and electron microscopical investigations indicated that the giant cells originated from mononuclear stromal cells with only slight histiocytic properties. The giant cell formation was probably induced by the infiltrating carcinomatous tissue which is also believed to induce new blood vessel formation. However, there is no evidence of a direct relationship between these features.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2985488</pmid><doi>10.1111/j.1365-2559.1985.tb02434.x</doi><tpages>11</tpages></addata></record> |
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| ispartof | Histopathology, 1985-02, Vol.9 (2), p.183-193 |
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| language | eng |
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| subjects | Adenocarcinoma, Mucinous - pathology Aged breast Breast Neoplasms - pathology carcinoma Carcinoma, Intraductal, Noninfiltrating - pathology Cell Nucleus - pathology Female giant cell Humans Immunochemistry Microscopy, Electron Middle Aged origin stroma |
| title | Carcinoma of the breast with stromal multinucleated giant cells |
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