Decline in Response to Nicotine in Aged Rat Striatum: Correlation with a Decrease in a Subpopulation of Nicotinic Receptors

Specific and reproducible changes involving the cholinergic and dopaminergic systems have been described in both the aging rodent and the human nervous system. Nevertheless, relatively little information is available on changes in nicotinic cholinergic receptors occurring in normal aging, and there...

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Veröffentlicht in:	Journal of neurochemistry 1993-12, Vol.61 (6), p.2225-2232
Hauptverfasser:	Schulz, David W., Kuchel, George A., Zigmond, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Animals Autoradiography Biological and medical sciences Cell Membrane - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - drug effects Corpus Striatum - growth & development Corpus Striatum - metabolism Dopamine - metabolism Fundamental and applied biological sciences. Psychology In Vitro Techniques Iodine Radioisotopes Kinetics Nicotine - pharmacology Nicotinic receptors Organ Specificity Potassium - pharmacology Rats Receptors, Nicotinic - metabolism Striatum Tritium Vertebrates: nervous system and sense organs
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