An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats
Using two-dimensional gel electrophoresis, an apparent genetic polymorphism was detected in the hypothalamus of a group of inbred Sprague-Dawley rats. The proteins involved in this polymorphism have a molecular weight of 57, 000 daltons and isoelectric points ranging from 6.1 to 6.3. These proteins...
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| Veröffentlicht in: | Brain research 1985-03, Vol.330 (1), p.170-173 |
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| container_end_page | 173 |
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| container_start_page | 170 |
| container_title | Brain research |
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| creator | Scouten, Charles W. Heydorn, William E. Joseph Creed, G. Malsbury, Charles W. Jacobowitz, David M. |
| description | Using two-dimensional gel electrophoresis, an apparent genetic polymorphism was detected in the hypothalamus of a group of inbred Sprague-Dawley rats. The proteins involved in this polymorphism have a molecular weight of 57, 000 daltons and isoelectric points ranging from 6.1 to 6.3. These proteins met four criteria that should be met before a positional shift on two-dimension gels can be attributed to a genetic polymorphism. This is the first report of the existence of a genetic polymorphism in the brains of a group of inbred Sprague-Dawley rats. The functional significance of this polymorphism is currently under investigation. |
| doi_str_mv | 10.1016/0006-8993(85)90022-8 |
| format | Article |
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The proteins involved in this polymorphism have a molecular weight of 57, 000 daltons and isoelectric points ranging from 6.1 to 6.3. These proteins met four criteria that should be met before a positional shift on two-dimension gels can be attributed to a genetic polymorphism. This is the first report of the existence of a genetic polymorphism in the brains of a group of inbred Sprague-Dawley rats. The functional significance of this polymorphism is currently under investigation.</description><subject>2-dimensional electrophoresis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Electrophoresis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genetic polymorphism</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Isoelectric Focusing</subject><subject>medial preoptic area</subject><subject>Molecular Weight</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - isolation & purification</subject><subject>Polymorphism, Genetic</subject><subject>Preoptic Area - analysis</subject><subject>proteins</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Ventromedial Hypothalamic Nucleus - analysis</subject><subject>ventromedial hypothalamus</subject><subject>Vertebrata</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKtvCPwDJB4TgkGLHiWNfkKpSWqRKPdC7NeuMu0ZJHGwHtP8eh13tEU7zRvO90egNIW84u-SMy0-MMVkprcUH1X7UjNV1pZ6RDVddXcm6Yc_J5oS8JOcp_SitEJqdkTOhlWyF3hC4mijMM0ScMn3CCbO3dA7Dfgxx3vk0UhciBTrHkNFPpWJa0SLzDuluP4e8gwHGJdHg6Pc5wtOC1Rf4PeCeRsjpFXnhYEj4-lgvyOPXm8fru-r-4fbb9dV9ZRve5ap3rJa6tiA755BxbV2RqmsdbotqW7SNtT3vZcdrLhAE6q3oOOhOWMXFBXl_WFsu_blgymb0yeIwwIRhSaaTrBjl_0HeNEK09Qo2B9DGkFJEZ-boR4h7w5lZP2DWeM0ar1Gt-fsBo4rt7XH_sh2xP5mOkZf5u-MckoXBRZisTydMNVLU7Yp9PmBYMvvlMZpkPU4Wex_RZtMH_-87_gAau6MS</recordid><startdate>19850318</startdate><enddate>19850318</enddate><creator>Scouten, Charles W.</creator><creator>Heydorn, William E.</creator><creator>Joseph Creed, G.</creator><creator>Malsbury, Charles W.</creator><creator>Jacobowitz, David M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19850318</creationdate><title>An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats</title><author>Scouten, Charles W. ; Heydorn, William E. ; Joseph Creed, G. ; Malsbury, Charles W. ; Jacobowitz, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-df02692ca67ffe019cfa67875febfa655ec4ccd1d671213ea3e9b371a973c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>2-dimensional electrophoresis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Electrophoresis</topic><topic>Fundamental and applied biological sciences. 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Biological and molecular evolution</topic><topic>Isoelectric Focusing</topic><topic>medial preoptic area</topic><topic>Molecular Weight</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - isolation & purification</topic><topic>Polymorphism, Genetic</topic><topic>Preoptic Area - analysis</topic><topic>proteins</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Ventromedial Hypothalamic Nucleus - analysis</topic><topic>ventromedial hypothalamus</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scouten, Charles W.</creatorcontrib><creatorcontrib>Heydorn, William E.</creatorcontrib><creatorcontrib>Joseph Creed, G.</creatorcontrib><creatorcontrib>Malsbury, Charles W.</creatorcontrib><creatorcontrib>Jacobowitz, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scouten, Charles W.</au><au>Heydorn, William E.</au><au>Joseph Creed, G.</au><au>Malsbury, Charles W.</au><au>Jacobowitz, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1985-03-18</date><risdate>1985</risdate><volume>330</volume><issue>1</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Using two-dimensional gel electrophoresis, an apparent genetic polymorphism was detected in the hypothalamus of a group of inbred Sprague-Dawley rats. The proteins involved in this polymorphism have a molecular weight of 57, 000 daltons and isoelectric points ranging from 6.1 to 6.3. These proteins met four criteria that should be met before a positional shift on two-dimension gels can be attributed to a genetic polymorphism. This is the first report of the existence of a genetic polymorphism in the brains of a group of inbred Sprague-Dawley rats. The functional significance of this polymorphism is currently under investigation.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3986539</pmid><doi>10.1016/0006-8993(85)90022-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1985-03, Vol.330 (1), p.170-173 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2-dimensional electrophoresis Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids Electrophoresis Fundamental and applied biological sciences. Psychology genetic polymorphism Genetics of eukaryotes. Biological and molecular evolution Isoelectric Focusing medial preoptic area Molecular Weight Nerve Tissue Proteins - genetics Nerve Tissue Proteins - isolation & purification Polymorphism, Genetic Preoptic Area - analysis proteins Rats Rats, Inbred Strains Ventromedial Hypothalamic Nucleus - analysis ventromedial hypothalamus Vertebrata |
| title | An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats |
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