Hemin-Induced Lipid Membrane Disorder and Increased Permeability: A Molecular Model for the Mechanism of Cell Lysis

The interaction between hemin and lipid bilayers was examined from the point of view of: (a) changes in membrane permeability, (b) changes in lipid organization, (c) catalysis of lipid peroxidation. The leakage of solutes trapped in inner aqueous compartments of vesicles and liposomes increased in a...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1993-11, Vol.307 (1), p.96-103
Hauptverfasser:	Schmitt, T.H., Frezzatti, W.A., Schreier, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial membranes and reconstituted systems Biological and medical sciences Cell Membrane - physiology Cholesterol Dimyristoylphosphatidylcholine Electron Spin Resonance Spectroscopy Fundamental and applied biological sciences. Psychology Hemin Kinetics Lipid Peroxidation Liposomes Membrane physicochemistry Models, Biological Molecular biophysics Oxygen Consumption Permeability Phosphatidylcholines Thiobarbituric Acid Reactive Substances - analysis Time Factors
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