Promoter independent down-regulation of the firefly luciferase gene by T3 and T3 receptor in CV1 cells

We report that the activity of the firefly luciferase (LUC) reporter gene is down-regulated by T3 and T3 receptor (TR) in the CV1 mammalian cell line, which is widely used for studies of TR action. Repression was highly reproducible, T3 and TR dependent, promoter independent, and observed regardless...

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Veröffentlicht in:	Molecular and cellular endocrinology 1993-09, Vol.95 (1-2), p.101-109
Hauptverfasser:	TILLMAN, J. B, CRONE, D. E, HYOUNG-SOON KIM, SPRUNG, C. N, SPINDLER, S. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell Line Cercopithecus aethiops Coleoptera - genetics Enzyme Induction - drug effects Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Genetic Vectors Kidney Luciferases - biosynthesis Luciferases - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Receptors, Thyroid Hormone - physiology Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Regulatory Sequences, Nucleic Acid Thymidine Kinase - biosynthesis Thymidine Kinase - genetics Transcription Factors - metabolism Transfection Triiodothyronine - pharmacology
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