Effects of GABAA receptor antagonism on inspiratory activities in kittens
In anesthetized kittens (< 1 to 24 days old), the effects of GABAA receptor antagonism on phrenic, hypoglossal and cervical sympathetic discharges were examined by i.v. bicuculline infusions during hyperoxia and hypoxia. Administration of bicuculline during hyperoxia produced marked increases in...
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| Veröffentlicht in: | Neuroscience letters 1993-10, Vol.160 (2), p.149-152 |
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| container_title | Neuroscience letters |
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| creator | SICA, A. L SIDDIQI, Z. A HUNDLEY, B. W GOOTMAN, P. M STEELE, A. M |
| description | In anesthetized kittens (< 1 to 24 days old), the effects of GABAA receptor antagonism on phrenic, hypoglossal and cervical sympathetic discharges were examined by i.v. bicuculline infusions during hyperoxia and hypoxia. Administration of bicuculline during hyperoxia produced marked increases in the amplitudes of inspiratory nerve discharges. During hypoxic stimulation (10% O2), the amplitudes of inspiratory activities decreased towards or below those observed during hyperoxia; bicuculline reversed this depression and restored inspiratory discharges. Our results indicated that GABAA receptors were functional shortly after birth, acting to mediate influences shaping inspiratory activity during hyperoxic breathing and during conditions of increased chemical drive. |
| doi_str_mv | 10.1016/0304-3940(93)90400-F |
| format | Article |
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Our results indicated that GABAA receptors were functional shortly after birth, acting to mediate influences shaping inspiratory activity during hyperoxic breathing and during conditions of increased chemical drive.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Bicuculline - administration & dosage</subject><subject>Bicuculline - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA-A Receptor Antagonists</subject><subject>Hypoglossal Nerve - drug effects</subject><subject>Hypoglossal Nerve - physiology</subject><subject>Hypoxia</subject><subject>Infusions, Intravenous</subject><subject>Inhalation - drug effects</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Oxygen</subject><subject>Phrenic Nerve - drug effects</subject><subject>Phrenic Nerve - physiology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVb_gcIeRPSwOpuPTXNci62Fghc9h2w2keh-maRC_71bu_Q0MO_zDsyD0HUGjxlk-RMQoCkRFO4FeRBAAdLlCZpmc45TLjg-RdMjco4uQvgCAJYxOkGTOaacUDZF6xdrjY4h6WyyKp6LIvFGmz52PlFtVJ9d60KTdG3i2tA7r4Zglygd3a-LzoRhnXy7GE0bLtGZVXUwV-OcoY_ly_viNd28rdaLYpNqTPOYEs0MUdqqvNQaSpxZUDkljHGFMeNEsEpgYTmpKi0wE5klKiemtGz4iVeKzNDd4W7vu5-tCVE2LmhT16o13TZIngMHgtkA0gOofReCN1b23jXK72QGcm9Q7vXIvR4piPw3KJdD7Wa8vy0bUx1Lo7Ihvx1zFbSqrVetduGIUQFzmgP5Azs3eFY</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>SICA, A. 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Vestibular system and equilibration</topic><topic>Oxygen</topic><topic>Phrenic Nerve - drug effects</topic><topic>Phrenic Nerve - physiology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SICA, A. L</creatorcontrib><creatorcontrib>SIDDIQI, Z. A</creatorcontrib><creatorcontrib>HUNDLEY, B. W</creatorcontrib><creatorcontrib>GOOTMAN, P. M</creatorcontrib><creatorcontrib>STEELE, A. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of GABAA receptor antagonism on inspiratory activities in kittens</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>160</volume><issue>2</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>In anesthetized kittens (< 1 to 24 days old), the effects of GABAA receptor antagonism on phrenic, hypoglossal and cervical sympathetic discharges were examined by i.v. bicuculline infusions during hyperoxia and hypoxia. Administration of bicuculline during hyperoxia produced marked increases in the amplitudes of inspiratory nerve discharges. During hypoxic stimulation (10% O2), the amplitudes of inspiratory activities decreased towards or below those observed during hyperoxia; bicuculline reversed this depression and restored inspiratory discharges. Our results indicated that GABAA receptors were functional shortly after birth, acting to mediate influences shaping inspiratory activity during hyperoxic breathing and during conditions of increased chemical drive.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>8247345</pmid><doi>10.1016/0304-3940(93)90400-F</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience letters, 1993-10, Vol.160 (2), p.149-152 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging - physiology Animals Animals, Newborn Bicuculline - administration & dosage Bicuculline - pharmacology Biological and medical sciences Cats Fundamental and applied biological sciences. Psychology GABA-A Receptor Antagonists Hypoglossal Nerve - drug effects Hypoglossal Nerve - physiology Hypoxia Infusions, Intravenous Inhalation - drug effects Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Oxygen Phrenic Nerve - drug effects Phrenic Nerve - physiology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs |
| title | Effects of GABAA receptor antagonism on inspiratory activities in kittens |
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