Influence of gender and age on performance of rats in the elevated plus maze apparatus
We have compared the performance of male and female Wistar rats at different ages (45, 60, 90, 120 and 150 days) in the elevated plus-maze test, a reliable animal model of anxiety. Up to 60 days of age, rats of both sexes exhibited a high number of entries and of time spent on open arms (50% or abov...
Gespeichert in:
| Veröffentlicht in: | Behavioural brain research 1993-09, Vol.56 (2), p.177-180 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 2 |
| container_start_page | 177 |
| container_title | Behavioural brain research |
| container_volume | 56 |
| creator | Imhof, Jania T. Coelho, Zuleide M.I. Schmitt, Marcelo L. Morato, Gina S. Carobrez, Antonio P. |
| description | We have compared the performance of male and female Wistar rats at different ages (45, 60, 90, 120 and 150 days) in the elevated plus-maze test, a reliable animal model of anxiety. Up to 60 days of age, rats of both sexes exhibited a high number of entries and of time spent on open arms (50% or above). At 120 days of age or more, rats of both sexes characteristically exhibited a reduction in the number of entries and of the time spent on open arms (below 50%). Within the range of 60 and 120 days there are statistically significant sex differences. At 90 days of age male rats showed a marked switch in their performance in the apparatus, reaching levels of the latter stage, whereas in females it happened around 120 days. These results suggest an ontogenetic difference in rats that accounts for at least two distinct performances for rats placed in an elevated plus-maze. Gender effects were found in a certain range, suggesting caution on interpreting data obtained in rats within 60 and 120 days old. Also, the results obtained highlight the importance of carefully controlling animal age in studies using the elevated plus-maze. |
| doi_str_mv | 10.1016/0166-4328(93)90036-P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76069749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>016643289390036P</els_id><sourcerecordid>76069749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-9cd94c56bf77b5e7ade57585e978dae4bdae9aed8d89533741bdb24e0760c5623</originalsourceid><addsrcrecordid>eNqFkU1LHTEUhoO06NX6DxSyKEUXo8lMPjeFIn5cEOrCug2Z5IyOzJfJzIX215vxDndpFzmBnOc9hOcgdELJBSVUXKYjMlbk6kwX55qQQmQPe2hFlcwzyZn-glY75AAdxvhKCGGE0320r3JGJM1X6GndVc0EnQPcV_gZOg8B285j-5xeOjxAqPrQ2gUIdoy47vD4Ahga2NgRPB6aKeLW_gNsh8EmZIrf0NfKNhGOl_sI_bm5fry6y-5_366vft1njgk1Ztp5zRwXZSVlyUFaD1xyxUFL5S2wMhVtwSuvNC8KyWjpy5wBkYKkWF4coR_buUPo3yaIo2nr6KBpbAf9FE3ihJZM_xekQiouhUwg24Iu9DEGqMwQ6taGv4YSM3s3s1QzSzW6MB_ezUOKnS7zp7IFvwstolP_-9K30dmmCsloHXcYU5oSWSTs5xaDJG1TQzDR1fN2fB3Ajcb39ef_eAddFJ6z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16785767</pqid></control><display><type>article</type><title>Influence of gender and age on performance of rats in the elevated plus maze apparatus</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Imhof, Jania T. ; Coelho, Zuleide M.I. ; Schmitt, Marcelo L. ; Morato, Gina S. ; Carobrez, Antonio P.</creator><creatorcontrib>Imhof, Jania T. ; Coelho, Zuleide M.I. ; Schmitt, Marcelo L. ; Morato, Gina S. ; Carobrez, Antonio P.</creatorcontrib><description>We have compared the performance of male and female Wistar rats at different ages (45, 60, 90, 120 and 150 days) in the elevated plus-maze test, a reliable animal model of anxiety. Up to 60 days of age, rats of both sexes exhibited a high number of entries and of time spent on open arms (50% or above). At 120 days of age or more, rats of both sexes characteristically exhibited a reduction in the number of entries and of the time spent on open arms (below 50%). Within the range of 60 and 120 days there are statistically significant sex differences. At 90 days of age male rats showed a marked switch in their performance in the apparatus, reaching levels of the latter stage, whereas in females it happened around 120 days. These results suggest an ontogenetic difference in rats that accounts for at least two distinct performances for rats placed in an elevated plus-maze. Gender effects were found in a certain range, suggesting caution on interpreting data obtained in rats within 60 and 120 days old. Also, the results obtained highlight the importance of carefully controlling animal age in studies using the elevated plus-maze.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/0166-4328(93)90036-P</identifier><identifier>PMID: 8240712</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Age ; Aging - physiology ; Animals ; Arousal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Discrimination Learning - physiology ; Elevated plus-maze anxiety ; Exploratory Behavior - physiology ; Fear - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Methods ; Motor Activity - physiology ; Ontogenesis ; Orientation - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychophysiology ; Rat ; Rats ; Sex difference ; Sex Factors ; Social Environment</subject><ispartof>Behavioural brain research, 1993-09, Vol.56 (2), p.177-180</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-9cd94c56bf77b5e7ade57585e978dae4bdae9aed8d89533741bdb24e0760c5623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0166-4328(93)90036-P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4891073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8240712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imhof, Jania T.</creatorcontrib><creatorcontrib>Coelho, Zuleide M.I.</creatorcontrib><creatorcontrib>Schmitt, Marcelo L.</creatorcontrib><creatorcontrib>Morato, Gina S.</creatorcontrib><creatorcontrib>Carobrez, Antonio P.</creatorcontrib><title>Influence of gender and age on performance of rats in the elevated plus maze apparatus</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>We have compared the performance of male and female Wistar rats at different ages (45, 60, 90, 120 and 150 days) in the elevated plus-maze test, a reliable animal model of anxiety. Up to 60 days of age, rats of both sexes exhibited a high number of entries and of time spent on open arms (50% or above). At 120 days of age or more, rats of both sexes characteristically exhibited a reduction in the number of entries and of the time spent on open arms (below 50%). Within the range of 60 and 120 days there are statistically significant sex differences. At 90 days of age male rats showed a marked switch in their performance in the apparatus, reaching levels of the latter stage, whereas in females it happened around 120 days. These results suggest an ontogenetic difference in rats that accounts for at least two distinct performances for rats placed in an elevated plus-maze. Gender effects were found in a certain range, suggesting caution on interpreting data obtained in rats within 60 and 120 days old. Also, the results obtained highlight the importance of carefully controlling animal age in studies using the elevated plus-maze.</description><subject>Age</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Discrimination Learning - physiology</subject><subject>Elevated plus-maze anxiety</subject><subject>Exploratory Behavior - physiology</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Methods</subject><subject>Motor Activity - physiology</subject><subject>Ontogenesis</subject><subject>Orientation - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychophysiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Sex difference</subject><subject>Sex Factors</subject><subject>Social Environment</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LHTEUhoO06NX6DxSyKEUXo8lMPjeFIn5cEOrCug2Z5IyOzJfJzIX215vxDndpFzmBnOc9hOcgdELJBSVUXKYjMlbk6kwX55qQQmQPe2hFlcwzyZn-glY75AAdxvhKCGGE0320r3JGJM1X6GndVc0EnQPcV_gZOg8B285j-5xeOjxAqPrQ2gUIdoy47vD4Ahga2NgRPB6aKeLW_gNsh8EmZIrf0NfKNhGOl_sI_bm5fry6y-5_366vft1njgk1Ztp5zRwXZSVlyUFaD1xyxUFL5S2wMhVtwSuvNC8KyWjpy5wBkYKkWF4coR_buUPo3yaIo2nr6KBpbAf9FE3ihJZM_xekQiouhUwg24Iu9DEGqMwQ6taGv4YSM3s3s1QzSzW6MB_ezUOKnS7zp7IFvwstolP_-9K30dmmCsloHXcYU5oSWSTs5xaDJG1TQzDR1fN2fB3Ajcb39ef_eAddFJ6z</recordid><startdate>19930930</startdate><enddate>19930930</enddate><creator>Imhof, Jania T.</creator><creator>Coelho, Zuleide M.I.</creator><creator>Schmitt, Marcelo L.</creator><creator>Morato, Gina S.</creator><creator>Carobrez, Antonio P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930930</creationdate><title>Influence of gender and age on performance of rats in the elevated plus maze apparatus</title><author>Imhof, Jania T. ; Coelho, Zuleide M.I. ; Schmitt, Marcelo L. ; Morato, Gina S. ; Carobrez, Antonio P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-9cd94c56bf77b5e7ade57585e978dae4bdae9aed8d89533741bdb24e0760c5623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Age</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Arousal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Discrimination Learning - physiology</topic><topic>Elevated plus-maze anxiety</topic><topic>Exploratory Behavior - physiology</topic><topic>Fear - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Methods</topic><topic>Motor Activity - physiology</topic><topic>Ontogenesis</topic><topic>Orientation - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychophysiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Sex difference</topic><topic>Sex Factors</topic><topic>Social Environment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imhof, Jania T.</creatorcontrib><creatorcontrib>Coelho, Zuleide M.I.</creatorcontrib><creatorcontrib>Schmitt, Marcelo L.</creatorcontrib><creatorcontrib>Morato, Gina S.</creatorcontrib><creatorcontrib>Carobrez, Antonio P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imhof, Jania T.</au><au>Coelho, Zuleide M.I.</au><au>Schmitt, Marcelo L.</au><au>Morato, Gina S.</au><au>Carobrez, Antonio P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of gender and age on performance of rats in the elevated plus maze apparatus</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>1993-09-30</date><risdate>1993</risdate><volume>56</volume><issue>2</issue><spage>177</spage><epage>180</epage><pages>177-180</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>We have compared the performance of male and female Wistar rats at different ages (45, 60, 90, 120 and 150 days) in the elevated plus-maze test, a reliable animal model of anxiety. Up to 60 days of age, rats of both sexes exhibited a high number of entries and of time spent on open arms (50% or above). At 120 days of age or more, rats of both sexes characteristically exhibited a reduction in the number of entries and of the time spent on open arms (below 50%). Within the range of 60 and 120 days there are statistically significant sex differences. At 90 days of age male rats showed a marked switch in their performance in the apparatus, reaching levels of the latter stage, whereas in females it happened around 120 days. These results suggest an ontogenetic difference in rats that accounts for at least two distinct performances for rats placed in an elevated plus-maze. Gender effects were found in a certain range, suggesting caution on interpreting data obtained in rats within 60 and 120 days old. Also, the results obtained highlight the importance of carefully controlling animal age in studies using the elevated plus-maze.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>8240712</pmid><doi>10.1016/0166-4328(93)90036-P</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 1993-09, Vol.56 (2), p.177-180 |
| issn | 0166-4328 1872-7549 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76069749 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Aging - physiology Animals Arousal - physiology Behavioral psychophysiology Biological and medical sciences Discrimination Learning - physiology Elevated plus-maze anxiety Exploratory Behavior - physiology Fear - physiology Female Fundamental and applied biological sciences. Psychology Male Methods Motor Activity - physiology Ontogenesis Orientation - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychophysiology Rat Rats Sex difference Sex Factors Social Environment |
| title | Influence of gender and age on performance of rats in the elevated plus maze apparatus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T21%3A49%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20gender%20and%20age%20on%20performance%20of%20rats%20in%20the%20elevated%20plus%20maze%20apparatus&rft.jtitle=Behavioural%20brain%20research&rft.au=Imhof,%20Jania%20T.&rft.date=1993-09-30&rft.volume=56&rft.issue=2&rft.spage=177&rft.epage=180&rft.pages=177-180&rft.issn=0166-4328&rft.eissn=1872-7549&rft.coden=BBREDI&rft_id=info:doi/10.1016/0166-4328(93)90036-P&rft_dat=%3Cproquest_cross%3E76069749%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16785767&rft_id=info:pmid/8240712&rft_els_id=016643289390036P&rfr_iscdi=true |