Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma
Nuclear DNA values were determined in 40 primary papillary thyroid carcinomas, as well as in 52 corresponding local recurrences and metastases were observed either at the time of diagnosis or up to 20 years later. The patient population consisted of 34 survivors and 6 nonsurvivors. In survivors, bot...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1985-06, Vol.45 (6), p.2890-2894 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | BACKDAHL, M COHN, K AUER, G FORSSLUND, G GRANBERG, P.-O LUNDELL, G LOWHAGEN, T WILLEMS, J.-S ZETTERBERG, A |
| description | Nuclear DNA values were determined in 40 primary papillary thyroid carcinomas, as well as in 52 corresponding local recurrences and metastases were observed either at the time of diagnosis or up to 20 years later. The patient population consisted of 34 survivors and 6 nonsurvivors. In survivors, both the primary tumors and their recurrences and metastases exhibited a majority of cells with DNA values within the normal diploid region, whereas nonsurvivors showed increased and scattered DNA values. In all cases, the primary tumors and the corresponding recurrences and metastases showed similar DNA distribution patterns even if many years had passed between the detection of the primary tumor and the metastases. The results indicate that in papillary thyroid carcinomas, the DNA distribution patterns in the primary tumor and the corresponding recurrences or metastases are generally similar throughout the entire period of disease. |
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The patient population consisted of 34 survivors and 6 nonsurvivors. In survivors, both the primary tumors and their recurrences and metastases exhibited a majority of cells with DNA values within the normal diploid region, whereas nonsurvivors showed increased and scattered DNA values. In all cases, the primary tumors and the corresponding recurrences and metastases showed similar DNA distribution patterns even if many years had passed between the detection of the primary tumor and the metastases. The results indicate that in papillary thyroid carcinomas, the DNA distribution patterns in the primary tumor and the corresponding recurrences or metastases are generally similar throughout the entire period of disease.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 3986815</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Applied sciences ; Carcinoma, Papillary - analysis ; Cell Nucleus - analysis ; DNA, Neoplasm - analysis ; Exact sciences and technology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Other techniques and industries ; Thyroid Neoplasms - analysis</subject><ispartof>Cancer research (Chicago, Ill.), 1985-06, Vol.45 (6), p.2890-2894</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8838809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3986815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BACKDAHL, M</creatorcontrib><creatorcontrib>COHN, K</creatorcontrib><creatorcontrib>AUER, G</creatorcontrib><creatorcontrib>FORSSLUND, G</creatorcontrib><creatorcontrib>GRANBERG, P.-O</creatorcontrib><creatorcontrib>LUNDELL, G</creatorcontrib><creatorcontrib>LOWHAGEN, T</creatorcontrib><creatorcontrib>WILLEMS, J.-S</creatorcontrib><creatorcontrib>ZETTERBERG, A</creatorcontrib><title>Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Nuclear DNA values were determined in 40 primary papillary thyroid carcinomas, as well as in 52 corresponding local recurrences and metastases were observed either at the time of diagnosis or up to 20 years later. The patient population consisted of 34 survivors and 6 nonsurvivors. In survivors, both the primary tumors and their recurrences and metastases exhibited a majority of cells with DNA values within the normal diploid region, whereas nonsurvivors showed increased and scattered DNA values. In all cases, the primary tumors and the corresponding recurrences and metastases showed similar DNA distribution patterns even if many years had passed between the detection of the primary tumor and the metastases. The results indicate that in papillary thyroid carcinomas, the DNA distribution patterns in the primary tumor and the corresponding recurrences or metastases are generally similar throughout the entire period of disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Applied sciences</subject><subject>Carcinoma, Papillary - analysis</subject><subject>Cell Nucleus - analysis</subject><subject>DNA, Neoplasm - analysis</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Other techniques and industries</subject><subject>Thyroid Neoplasms - analysis</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKxDAQhoMo67r6CEIO4q2QNkk7PS6rrsKiF8VjmSYpG2mTmqSHfXsrFk_D8P0M3_xnZJ1LDlklhDwna8YYZFJUxSW5ivFrXmXO5IqseA0l5HJNPnd-GDHY6B31HXWT6g0G-vC6pcq7ZFyi1tEx2AHDiaLTdDAJY8JkFR1xtH3_C9LxFLzVVGFQ1vkBr8lFh300N8vckI-nx_fdc3Z427_stofsWJSQsq7jbc2x1DlKPosLBZWaNQvR6lq3QoBGrFgOBqSCupbMCCzzglXaMI0t35D7v7tj8N-TiakZbFRmtnLGT7GpSlZCXYk5eLsEp3YwulleapYmZn63cIwK-y6gUzb-xwA4AKv5D1zxaF8</recordid><startdate>19850601</startdate><enddate>19850601</enddate><creator>BACKDAHL, M</creator><creator>COHN, K</creator><creator>AUER, G</creator><creator>FORSSLUND, G</creator><creator>GRANBERG, P.-O</creator><creator>LUNDELL, G</creator><creator>LOWHAGEN, T</creator><creator>WILLEMS, J.-S</creator><creator>ZETTERBERG, A</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19850601</creationdate><title>Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma</title><author>BACKDAHL, M ; COHN, K ; AUER, G ; FORSSLUND, G ; GRANBERG, P.-O ; LUNDELL, G ; LOWHAGEN, T ; WILLEMS, J.-S ; ZETTERBERG, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-ff3b93a6d1a535384c87c00024bd9db448daa7018e85c89950e4a61207de0dab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Applied sciences</topic><topic>Carcinoma, Papillary - analysis</topic><topic>Cell Nucleus - analysis</topic><topic>DNA, Neoplasm - analysis</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Other techniques and industries</topic><topic>Thyroid Neoplasms - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BACKDAHL, M</creatorcontrib><creatorcontrib>COHN, K</creatorcontrib><creatorcontrib>AUER, G</creatorcontrib><creatorcontrib>FORSSLUND, G</creatorcontrib><creatorcontrib>GRANBERG, P.-O</creatorcontrib><creatorcontrib>LUNDELL, G</creatorcontrib><creatorcontrib>LOWHAGEN, T</creatorcontrib><creatorcontrib>WILLEMS, J.-S</creatorcontrib><creatorcontrib>ZETTERBERG, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BACKDAHL, M</au><au>COHN, K</au><au>AUER, G</au><au>FORSSLUND, G</au><au>GRANBERG, P.-O</au><au>LUNDELL, G</au><au>LOWHAGEN, T</au><au>WILLEMS, J.-S</au><au>ZETTERBERG, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1985-06-01</date><risdate>1985</risdate><volume>45</volume><issue>6</issue><spage>2890</spage><epage>2894</epage><pages>2890-2894</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Nuclear DNA values were determined in 40 primary papillary thyroid carcinomas, as well as in 52 corresponding local recurrences and metastases were observed either at the time of diagnosis or up to 20 years later. The patient population consisted of 34 survivors and 6 nonsurvivors. In survivors, both the primary tumors and their recurrences and metastases exhibited a majority of cells with DNA values within the normal diploid region, whereas nonsurvivors showed increased and scattered DNA values. In all cases, the primary tumors and the corresponding recurrences and metastases showed similar DNA distribution patterns even if many years had passed between the detection of the primary tumor and the metastases. The results indicate that in papillary thyroid carcinomas, the DNA distribution patterns in the primary tumor and the corresponding recurrences or metastases are generally similar throughout the entire period of disease.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>3986815</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1985-06, Vol.45 (6), p.2890-2894 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Adult Aged Applied sciences Carcinoma, Papillary - analysis Cell Nucleus - analysis DNA, Neoplasm - analysis Exact sciences and technology Female Humans Male Middle Aged Neoplasm Metastasis Other techniques and industries Thyroid Neoplasms - analysis |
| title | Comparison of nuclear DNA content in primary and metastatic papillary thyroid carcinoma |
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