Diurnal changes in the rate of cholesterogenesis in hepatocytes from fed and starved rats: Effects of precursors and pancreatic hormones in vitro

The activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) varied with a diurnal periodicity in hepatocytes prepared at different times from rats accustomed to a controlled feeding and lighting schedule. The rates of sterol synthesis varied in a similar manner but the maximu...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1985-04, Vol.238 (1), p.135-145
Hauptverfasser:	Björnsson, Olafur G., Pullinger, Clive R., Gibbons, Geoffrey F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol - biosynthesis Circadian Rhythm Diet Fatty Acids - biosynthesis Glucagon - pharmacology Hydroxymethylglutaryl CoA Reductases - metabolism In Vitro Techniques Insulin - pharmacology Liver - enzymology Liver - metabolism Male Pancreatic Hormones - physiology Pyruvates - pharmacology Rats Rats, Inbred Strains Starvation - metabolism Substrate Specificity
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