Diclofenac for pain after hip surgery
Sixty-eight patients were studied during the day after hip replacement for arthrosis. No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3...
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| Veröffentlicht in: | Acta orthopaedica 1985-01, Vol.56 (1), p.28-31 |
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| container_title | Acta orthopaedica |
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| creator | Lindgren, Urban Djupsjö, Henrik |
| description | Sixty-eight patients were studied during the day after hip replacement for arthrosis. No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3.5 h. Pain was recorded before and for 3 h after these injections. Ten patients in the placebo group demanded rescue drug because of insufficient pain relief. Four patients discontinued the study due to side effects: nausea (one patient in the placebo group) and somnolence or nausea (three patients in the pethidine group). Assessed both by visual analogue scale (VAS), and by the investigator's assessment, the diclofenac group had less pain than the pethidine and placebo groups. Side effects were least frequent in the diclofenac group. This study demonstrates that at the doses used here, compared with pethidine, diclofenac is more effective in relieving postoperative pain and has fewer side effects. |
| doi_str_mv | 10.3109/17453678508992974 |
| format | Article |
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No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3.5 h. Pain was recorded before and for 3 h after these injections. Ten patients in the placebo group demanded rescue drug because of insufficient pain relief. Four patients discontinued the study due to side effects: nausea (one patient in the placebo group) and somnolence or nausea (three patients in the pethidine group). Assessed both by visual analogue scale (VAS), and by the investigator's assessment, the diclofenac group had less pain than the pethidine and placebo groups. Side effects were least frequent in the diclofenac group. This study demonstrates that at the doses used here, compared with pethidine, diclofenac is more effective in relieving postoperative pain and has fewer side effects.</description><identifier>ISSN: 1745-3674</identifier><identifier>ISSN: 0001-6470</identifier><identifier>EISSN: 1745-3682</identifier><identifier>DOI: 10.3109/17453678508992974</identifier><identifier>PMID: 3885672</identifier><identifier>CODEN: AOSAAK</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Aged ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Clinical Trials as Topic ; Diclofenac - therapeutic use ; Double-Blind Method ; Female ; Hip Prosthesis ; Humans ; Male ; Medical sciences ; Meperidine - therapeutic use ; Middle Aged ; Pain, Postoperative - drug therapy ; Pharmacology. Drug treatments ; Phenylacetates - therapeutic use ; Placebos ; Time Factors</subject><ispartof>Acta orthopaedica, 1985-01, Vol.56 (1), p.28-31</ispartof><rights>1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-9427eccb2560806289f71019f8978e7fdde76b5d604d9a37910d90ebf5d38cc3</citedby><cites>FETCH-LOGICAL-c473t-9427eccb2560806289f71019f8978e7fdde76b5d604d9a37910d90ebf5d38cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8408608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3885672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindgren, Urban</creatorcontrib><creatorcontrib>Djupsjö, Henrik</creatorcontrib><title>Diclofenac for pain after hip surgery</title><title>Acta orthopaedica</title><addtitle>Acta Orthop Scand</addtitle><description>Sixty-eight patients were studied during the day after hip replacement for arthrosis. No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3.5 h. Pain was recorded before and for 3 h after these injections. Ten patients in the placebo group demanded rescue drug because of insufficient pain relief. Four patients discontinued the study due to side effects: nausea (one patient in the placebo group) and somnolence or nausea (three patients in the pethidine group). Assessed both by visual analogue scale (VAS), and by the investigator's assessment, the diclofenac group had less pain than the pethidine and placebo groups. Side effects were least frequent in the diclofenac group. This study demonstrates that at the doses used here, compared with pethidine, diclofenac is more effective in relieving postoperative pain and has fewer side effects.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Clinical Trials as Topic</subject><subject>Diclofenac - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Hip Prosthesis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meperidine - therapeutic use</subject><subject>Middle Aged</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylacetates - therapeutic use</subject><subject>Placebos</subject><subject>Time Factors</subject><issn>1745-3674</issn><issn>0001-6470</issn><issn>1745-3682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAchoMoc07_AA9CD-qtmjZpk6AXmZ8w8LJ7SPPhOtKmJi2y_96M1YEInhLye94feR8AzjN4gzLIbjOCC1QSWkDKWM4IPgDT7VuKSpof7u8EH4OTENYQIooZnIAJorQoST4FV4-1tM7oVsjEOJ90om4TYXrtk1XdJWHwH9pvTsGRETbos_GcgeXz03L-mi7eX97mD4tUYoL6lOGcaCmrvCghhWVOmSEZzJihjFBNjFKalFWhSogVE4iwDCoGdWUKhaiUaAaud2s77z4HHXre1EFqa0Wr3RA4KWHsgmkEsx0ovQvBa8M7XzfCb3gG-dYM_2MmZi7G5UPVaLVPjCri_HKciyCFNV60sg57jGJIY6uI3e-wuo2-GvHlvFW8Fxvr_E8G_feLu1_xlRa2X0nhNV-7wbfR7j8dvgFZv45-</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Lindgren, Urban</creator><creator>Djupsjö, Henrik</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Diclofenac for pain after hip surgery</title><author>Lindgren, Urban ; Djupsjö, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-9427eccb2560806289f71019f8978e7fdde76b5d604d9a37910d90ebf5d38cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Clinical Trials as Topic</topic><topic>Diclofenac - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Hip Prosthesis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meperidine - therapeutic use</topic><topic>Middle Aged</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylacetates - therapeutic use</topic><topic>Placebos</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindgren, Urban</creatorcontrib><creatorcontrib>Djupsjö, Henrik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta orthopaedica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindgren, Urban</au><au>Djupsjö, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diclofenac for pain after hip surgery</atitle><jtitle>Acta orthopaedica</jtitle><addtitle>Acta Orthop Scand</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>56</volume><issue>1</issue><spage>28</spage><epage>31</epage><pages>28-31</pages><issn>1745-3674</issn><issn>0001-6470</issn><eissn>1745-3682</eissn><coden>AOSAAK</coden><abstract>Sixty-eight patients were studied during the day after hip replacement for arthrosis. No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3.5 h. Pain was recorded before and for 3 h after these injections. Ten patients in the placebo group demanded rescue drug because of insufficient pain relief. Four patients discontinued the study due to side effects: nausea (one patient in the placebo group) and somnolence or nausea (three patients in the pethidine group). Assessed both by visual analogue scale (VAS), and by the investigator's assessment, the diclofenac group had less pain than the pethidine and placebo groups. Side effects were least frequent in the diclofenac group. This study demonstrates that at the doses used here, compared with pethidine, diclofenac is more effective in relieving postoperative pain and has fewer side effects.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>3885672</pmid><doi>10.3109/17453678508992974</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1745-3674 |
| ispartof | Acta orthopaedica, 1985-01, Vol.56 (1), p.28-31 |
| issn | 1745-3674 0001-6470 1745-3682 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Clinical Trials as Topic Diclofenac - therapeutic use Double-Blind Method Female Hip Prosthesis Humans Male Medical sciences Meperidine - therapeutic use Middle Aged Pain, Postoperative - drug therapy Pharmacology. Drug treatments Phenylacetates - therapeutic use Placebos Time Factors |
| title | Diclofenac for pain after hip surgery |
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