$Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP$

Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP

Single crystals of human placental 17β-hydroxysteroid dehydrogenase, an enzyme that plays an important role in the interconversion of estrogens, were obtained as the NADP + complex. These are the first crystals suitable for complete X-ray structure analysis ever reported for a steroid-converting enz...

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Veröffentlicht in:	Journal of molecular biology 1993-11, Vol.234 (1), p.242-244
Hauptverfasser:	Zhu, D.-W., Lee, X., Breton, R., Ghosh, D., Pangborn, W., Duax, W.L., Lin, S.-X.
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - ultrastructure 17β-hydroxysteroid dehydrogenase Analytical, structural and metabolic biochemistry Biological and medical sciences Crystalline structure crystallization Crystallography, X-Ray Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Molecular biophysics NADP - chemistry Oxidoreductases Placenta - enzymology steroid converting enzyme Structure in molecular biology X-ray diffraction
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