Influence of age on venous physiologic parameters
Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep...
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| Veröffentlicht in: | Journal of vascular surgery 1993-11, Vol.18 (5), p.749-752 |
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| container_title | Journal of vascular surgery |
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| creator | Schina, Michael J. Neumyer, Marsha M. Healy, Dean A. Atnip, Robert G. Thiele, Brian L. |
| description | Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep venous thrombosis.
Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction.
Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups.
Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly. |
| doi_str_mv | 10.1016/0741-5214(93)90327-I |
| format | Article |
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Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction.
Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups.
Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/0741-5214(93)90327-I</identifier><identifier>PMID: 8230559</identifier><identifier>CODEN: JVSUES</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Blood vessels and receptors ; Blood Volume ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Leg - blood supply ; Male ; Middle Aged ; Plethysmography ; Prospective Studies ; Risk Factors ; Thrombophlebitis - physiopathology ; Veins - physiology ; Vertebrates: cardiovascular system</subject><ispartof>Journal of vascular surgery, 1993-11, Vol.18 (5), p.749-752</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347i-cdc6f72ec09c56ef732d558acc1bf1e2637c79c5643f5356e4486ddd9fad53d93</citedby><cites>FETCH-LOGICAL-c347i-cdc6f72ec09c56ef732d558acc1bf1e2637c79c5643f5356e4486ddd9fad53d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0741-5214(93)90327-I$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,3552,23937,23938,25147,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3948855$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8230559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schina, Michael J.</creatorcontrib><creatorcontrib>Neumyer, Marsha M.</creatorcontrib><creatorcontrib>Healy, Dean A.</creatorcontrib><creatorcontrib>Atnip, Robert G.</creatorcontrib><creatorcontrib>Thiele, Brian L.</creatorcontrib><title>Influence of age on venous physiologic parameters</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep venous thrombosis.
Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction.
Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups.
Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>Blood Volume</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plethysmography</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Thrombophlebitis - physiopathology</subject><subject>Veins - physiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gcIsRHQxmkySyWQjSPExUHCj65AmNzUyj5p0Cv33ztihS1dncb57OXwIXRJ8TzDJH7BgJOUZYbeS3klMM5GWR2hKsBRpXmB5jKYH5BSdxfiNMSG8EBM0KTKKOZdTRMrGVR00BpLWJXrVR5NsoWm7mKy_dtG3VbvyJlnroGvYQIjn6MTpKsLFmDP0-fL8MX9LF--v5fxpkRrKhE-NNbkTGRgsDc_BCZpZzgttDFk6AllOhRFDxajjtCcYK3JrrXTacmolnaGb_d91aH86iBtV-2igqnQD_TolcpwzRkkPsj1oQhtjAKfWwdc67BTBajClBg1q0KAkVX-mVNmfXY3_u2UN9nA0qun767HX0ejKBd0YHw8YlawoOO-xxz0GvYuth6Ci8YNP6wOYjbKt_3_HL19khBk</recordid><startdate>199311</startdate><enddate>199311</enddate><creator>Schina, Michael J.</creator><creator>Neumyer, Marsha M.</creator><creator>Healy, Dean A.</creator><creator>Atnip, Robert G.</creator><creator>Thiele, Brian L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199311</creationdate><title>Influence of age on venous physiologic parameters</title><author>Schina, Michael J. ; Neumyer, Marsha M. ; Healy, Dean A. ; Atnip, Robert G. ; Thiele, Brian L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347i-cdc6f72ec09c56ef732d558acc1bf1e2637c79c5643f5356e4486ddd9fad53d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>Blood Volume</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Leg - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plethysmography</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Thrombophlebitis - physiopathology</topic><topic>Veins - physiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schina, Michael J.</creatorcontrib><creatorcontrib>Neumyer, Marsha M.</creatorcontrib><creatorcontrib>Healy, Dean A.</creatorcontrib><creatorcontrib>Atnip, Robert G.</creatorcontrib><creatorcontrib>Thiele, Brian L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schina, Michael J.</au><au>Neumyer, Marsha M.</au><au>Healy, Dean A.</au><au>Atnip, Robert G.</au><au>Thiele, Brian L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of age on venous physiologic parameters</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>1993-11</date><risdate>1993</risdate><volume>18</volume><issue>5</issue><spage>749</spage><epage>752</epage><pages>749-752</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><coden>JVSUES</coden><abstract>Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep venous thrombosis.
Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction.
Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups.
Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8230559</pmid><doi>10.1016/0741-5214(93)90327-I</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging - physiology Biological and medical sciences Blood vessels and receptors Blood Volume Female Fundamental and applied biological sciences. Psychology Humans Leg - blood supply Male Middle Aged Plethysmography Prospective Studies Risk Factors Thrombophlebitis - physiopathology Veins - physiology Vertebrates: cardiovascular system |
| title | Influence of age on venous physiologic parameters |
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