Relationship between lipid composition and drug metabolizing capacity of human liver

The relationship between hepatic glycerolipids and microsomal drug-metabolizing enzymes was studied in liver biopsies from 41 subjects. The series included obese, diabetic, epileptic and chronic alcoholic patients, all of whom were hospitalized for suspected hepatic ailments (fatty liver, hepatitis...

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Veröffentlicht in:	European journal of clinical pharmacology 1985-01, Vol.27 (6), p.727-732
Hauptverfasser:	SAVOLAINEN, M. J, ARRANTO, A. J, HASSINEN, I. E, LUOMA, P. V, PELKONEN, R. O, SOTANIEMI, E. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipyrine - blood Biological and medical sciences Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - metabolism Enzyme Induction Female General pharmacology Half-Life Humans Lipid Metabolism Liver - metabolism Male Medical sciences Microsomes, Liver - enzymology Middle Aged Pharmaceutical Preparations - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phosphatidate Phosphatase - metabolism Phospholipids - blood Triglycerides - blood
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