Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from Rwanda, 1984–1990
A total of 383 clinical isolates of Streptococcus pneumoniae, obtained from an equal number of patients in Kigali, Rwanda, was tested for resistance to penicillin G with a I μg oxacillin disc. Of these isolates, 99 (25·8%) showed reduced zones of inhibition. By means of an agar dilution method, 21%...
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| Veröffentlicht in: | The Journal of infection 1993-09, Vol.27 (2), p.157-168 |
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| creator | Bogaerts, J. Lepage, P. Taelman, H. Rouvroy, D. Batungwanayo, J. Kestelyn, P. Hitimana, D.-G. Van de Perre, P. Vandepitte, J. Verbist, L. Verhaegen, J. |
| description | A total of 383 clinical isolates of
Streptococcus pneumoniae, obtained from an equal number of patients in Kigali, Rwanda, was tested for resistance to penicillin G with a I μg oxacillin disc. Of these isolates, 99 (25·8%) showed reduced zones of inhibition. By means of an agar dilution method, 21% all isolates were confirmed as relatively resistant (MIC ⩾ 0·12− ⩽ 1·0 mg/l) strains of
Streptococcus pneumoniae (RRSP). A high degree of resistance to penicillin G (MIC ⩾ 2 mg/l) was not observed. Resistance to chloramphenicol (MIC ⩾ 8 mg/l) was found in 31% RRSP and in 6% penicillin susceptible strains (PSSP). Doxycycline resistance was common in both RRSP and PSSP strains. All isolates remained fully susceptible to erythromycin. Children more often harboured a strain giving a reduced inhibition zone than did adults (74/230 versus 25/153;
P = 0·0005).
A total of 32 serotypes or serogroups were identified, seven of them relating to 64.8% all isolates typed. Of all the isolates 84% belonged to a serotype represented in the 23-valent vaccine or to a cross-reacting serotype. Serotype 25, not included in the vaccine, accounted for 10·7% typed isolates from adults but only for 2·0% typed isolates from children.
Results of susceptibility testing and clinical experience suggest that penicillin G, ampicillin and chloramphenicol should not be used alone as empirical treatment for pneumococcal meningitis in patients in Rwanda. |
| doi_str_mv | 10.1016/0163-4453(93)94728-T |
| format | Article |
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Streptococcus pneumoniae, obtained from an equal number of patients in Kigali, Rwanda, was tested for resistance to penicillin G with a I μg oxacillin disc. Of these isolates, 99 (25·8%) showed reduced zones of inhibition. By means of an agar dilution method, 21% all isolates were confirmed as relatively resistant (MIC ⩾ 0·12− ⩽ 1·0 mg/l) strains of
Streptococcus pneumoniae (RRSP). A high degree of resistance to penicillin G (MIC ⩾ 2 mg/l) was not observed. Resistance to chloramphenicol (MIC ⩾ 8 mg/l) was found in 31% RRSP and in 6% penicillin susceptible strains (PSSP). Doxycycline resistance was common in both RRSP and PSSP strains. All isolates remained fully susceptible to erythromycin. Children more often harboured a strain giving a reduced inhibition zone than did adults (74/230 versus 25/153;
P = 0·0005).
A total of 32 serotypes or serogroups were identified, seven of them relating to 64.8% all isolates typed. Of all the isolates 84% belonged to a serotype represented in the 23-valent vaccine or to a cross-reacting serotype. Serotype 25, not included in the vaccine, accounted for 10·7% typed isolates from adults but only for 2·0% typed isolates from children.
Results of susceptibility testing and clinical experience suggest that penicillin G, ampicillin and chloramphenicol should not be used alone as empirical treatment for pneumococcal meningitis in patients in Rwanda.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/0163-4453(93)94728-T</identifier><identifier>PMID: 8228297</identifier><identifier>CODEN: JINFD2</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteremia - microbiology ; Biological and medical sciences ; Child ; Drug Resistance, Microbial ; Female ; Humans ; Male ; Medical sciences ; Meningitis - microbiology ; Microbial Sensitivity Tests ; Middle Aged ; Penicillin G - pharmacology ; Pharmacology. Drug treatments ; Rwanda ; Serotyping ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - drug effects ; Tropical medicine</subject><ispartof>The Journal of infection, 1993-09, Vol.27 (2), p.157-168</ispartof><rights>1993 The British Society for the Study of Infection</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2b1203aba709f0fac2e4a6e68f58d1b1b33b76b5836a3060826436defeebb64f3</citedby><cites>FETCH-LOGICAL-c417t-2b1203aba709f0fac2e4a6e68f58d1b1b33b76b5836a3060826436defeebb64f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0163-4453(93)94728-T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3813251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8228297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bogaerts, J.</creatorcontrib><creatorcontrib>Lepage, P.</creatorcontrib><creatorcontrib>Taelman, H.</creatorcontrib><creatorcontrib>Rouvroy, D.</creatorcontrib><creatorcontrib>Batungwanayo, J.</creatorcontrib><creatorcontrib>Kestelyn, P.</creatorcontrib><creatorcontrib>Hitimana, D.-G.</creatorcontrib><creatorcontrib>Van de Perre, P.</creatorcontrib><creatorcontrib>Vandepitte, J.</creatorcontrib><creatorcontrib>Verbist, L.</creatorcontrib><creatorcontrib>Verhaegen, J.</creatorcontrib><title>Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from Rwanda, 1984–1990</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>A total of 383 clinical isolates of
Streptococcus pneumoniae, obtained from an equal number of patients in Kigali, Rwanda, was tested for resistance to penicillin G with a I μg oxacillin disc. Of these isolates, 99 (25·8%) showed reduced zones of inhibition. By means of an agar dilution method, 21% all isolates were confirmed as relatively resistant (MIC ⩾ 0·12− ⩽ 1·0 mg/l) strains of
Streptococcus pneumoniae (RRSP). A high degree of resistance to penicillin G (MIC ⩾ 2 mg/l) was not observed. Resistance to chloramphenicol (MIC ⩾ 8 mg/l) was found in 31% RRSP and in 6% penicillin susceptible strains (PSSP). Doxycycline resistance was common in both RRSP and PSSP strains. All isolates remained fully susceptible to erythromycin. Children more often harboured a strain giving a reduced inhibition zone than did adults (74/230 versus 25/153;
P = 0·0005).
A total of 32 serotypes or serogroups were identified, seven of them relating to 64.8% all isolates typed. Of all the isolates 84% belonged to a serotype represented in the 23-valent vaccine or to a cross-reacting serotype. Serotype 25, not included in the vaccine, accounted for 10·7% typed isolates from adults but only for 2·0% typed isolates from children.
Results of susceptibility testing and clinical experience suggest that penicillin G, ampicillin and chloramphenicol should not be used alone as empirical treatment for pneumococcal meningitis in patients in Rwanda.</description><subject>Adult</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteremia - microbiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Drug Resistance, Microbial</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis - microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Penicillin G - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rwanda</subject><subject>Serotyping</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Tropical medicine</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFDEUhoMoY0_rGyhkIaJgaW6VqmwGhmG8wICg7TokqROIVlXKJKX0znfwDX0S03TTS4WELM73H06-g9ATSl5TQuWbenkjRMtfKP5SiY71ze4e2tCWs4Z1gt1HmzPyEF3m_JUQoriSF-iiZ6xnqtugb9dzCVNwKdpgRpzX7GApwYYxlD0284AzpFj2C-Ah5JKCXUuIM44efy6potFF59aMlxnWKc7BAPYpTvjTzxo2rzBVvfjz6zdVijxCD7wZMzw-vVv05e3t7uZ9c_fx3Yeb67vGCdqVhlnKCDfWdER54o1jIIwE2fu2H6illnPbSdv2XBpOJOmZFFwO4AGslcLzLXp-7Luk-H2FXPQU6rfG0cwQ16w7SSSXnP0XpLJjileHWySOYPWUcwKvlxQmk_aaEn1Yhj6Y1gfTWtVzWIbe1djTU__VTjCcQyf7tf7sVDfZmdEnM7uQzxjvKWctrdjVEYMq7UeApLMLMDsYQgJX9BDDv-f4C-NTp2c</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Bogaerts, J.</creator><creator>Lepage, P.</creator><creator>Taelman, H.</creator><creator>Rouvroy, D.</creator><creator>Batungwanayo, J.</creator><creator>Kestelyn, P.</creator><creator>Hitimana, D.-G.</creator><creator>Van de Perre, P.</creator><creator>Vandepitte, J.</creator><creator>Verbist, L.</creator><creator>Verhaegen, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from Rwanda, 1984–1990</title><author>Bogaerts, J. ; Lepage, P. ; Taelman, H. ; Rouvroy, D. ; Batungwanayo, J. ; Kestelyn, P. ; Hitimana, D.-G. ; Van de Perre, P. ; Vandepitte, J. ; Verbist, L. ; Verhaegen, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2b1203aba709f0fac2e4a6e68f58d1b1b33b76b5836a3060826436defeebb64f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Antibacterial agents</topic><topic>Antibiotics. 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Streptococcus pneumoniae, obtained from an equal number of patients in Kigali, Rwanda, was tested for resistance to penicillin G with a I μg oxacillin disc. Of these isolates, 99 (25·8%) showed reduced zones of inhibition. By means of an agar dilution method, 21% all isolates were confirmed as relatively resistant (MIC ⩾ 0·12− ⩽ 1·0 mg/l) strains of
Streptococcus pneumoniae (RRSP). A high degree of resistance to penicillin G (MIC ⩾ 2 mg/l) was not observed. Resistance to chloramphenicol (MIC ⩾ 8 mg/l) was found in 31% RRSP and in 6% penicillin susceptible strains (PSSP). Doxycycline resistance was common in both RRSP and PSSP strains. All isolates remained fully susceptible to erythromycin. Children more often harboured a strain giving a reduced inhibition zone than did adults (74/230 versus 25/153;
P = 0·0005).
A total of 32 serotypes or serogroups were identified, seven of them relating to 64.8% all isolates typed. Of all the isolates 84% belonged to a serotype represented in the 23-valent vaccine or to a cross-reacting serotype. Serotype 25, not included in the vaccine, accounted for 10·7% typed isolates from adults but only for 2·0% typed isolates from children.
Results of susceptibility testing and clinical experience suggest that penicillin G, ampicillin and chloramphenicol should not be used alone as empirical treatment for pneumococcal meningitis in patients in Rwanda.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>8228297</pmid><doi>10.1016/0163-4453(93)94728-T</doi><tpages>12</tpages></addata></record> |
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| ispartof | The Journal of infection, 1993-09, Vol.27 (2), p.157-168 |
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| subjects | Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteremia - microbiology Biological and medical sciences Child Drug Resistance, Microbial Female Humans Male Medical sciences Meningitis - microbiology Microbial Sensitivity Tests Middle Aged Penicillin G - pharmacology Pharmacology. Drug treatments Rwanda Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Tropical medicine |
| title | Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from Rwanda, 1984–1990 |
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