Studies on the Alkylation of Choline Acetyltransferase by Choline Mustard Aziridinium Ion

: Although a potent irreversible inhibitor of high‐affinity choline transport in rat brain synaptosomes, choline mustard aziridinium ion (ChM Az) appeared to be a relatively weak inhibitor of choline acetyltransferase (ChAT) in rat brain homogenates, and evidence for irreversible binding of this com...

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Veröffentlicht in:	Journal of neurochemistry 1985-06, Vol.44 (6), p.1951-1954
Hauptverfasser:	Rylett, R. Jane, Colhoun, E. Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Aziridinium ion Biological and medical sciences Brain - enzymology Choline - analogs & derivatives Choline - pharmacology Choline acetyltransferase Choline mustard Choline O-Acetyltransferase - antagonists & inhibitors General and cellular metabolism. Vitamins Kinetics Medical sciences Neuromuscular Blocking Agents - pharmacology Pharmacology. Drug treatments Rats Synaptosomes - enzymology
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