Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report
Immunosuppressive chemotherapy and bone marrow transplantation are increasingly used to treat and, in some cases, cure numerous malignant conditions. The systemic sequelae as a result of these immunosuppressive techniques lead to a host of oral and dental complications. The direct and indirect stoma...
Gespeichert in:
| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology oral medicine, oral pathology, 1993-10, Vol.76 (4), p.441-448 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 448 |
|---|---|
| container_issue | 4 |
| container_start_page | 441 |
| container_title | Oral surgery, oral medicine, oral pathology |
| container_volume | 76 |
| creator | RUTKAUSKAS, J. S DAVIS, J. W |
| description | Immunosuppressive chemotherapy and bone marrow transplantation are increasingly used to treat and, in some cases, cure numerous malignant conditions. The systemic sequelae as a result of these immunosuppressive techniques lead to a host of oral and dental complications. The direct and indirect stomatotoxic effects lead to development of ulcerative, hemorrhagic, or infectious complications that potentially can lead to increased mortality and morbidity. Chlorhexidine was studied to evaluate its broad spectrum antimicrobial properties and to evaluate its effect on immunosuppression-induced mucositis. Our double-blind randomized study revealed that chlorhexidine versus controls had considerable effect in the bone marrow transplant cohort. Patients who received chlorhexidine while undergoing bone marrow transplantation were found to exhibit fewer and less painful mucositis lesions. This study supports prophylactic use of chlorhexidine in patients who undergo bone marrow transplantation. |
| doi_str_mv | 10.1016/0030-4220(93)90010-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76057376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76057376</sourcerecordid><originalsourceid>FETCH-LOGICAL-j330t-fe68209c039e6724d322ad73423b0e6b9a8b040ca90fdf51060ac33a198a03523</originalsourceid><addsrcrecordid>eNo9kEtLxDAUhYMo4zj6DxSyENFF9Sa3TRp3MowPGHDjrEuapk6Gvkxacf69FcusDpfv43I4hFwyuGfAxAMAQhRzDrcK7xQAg4gfkTlLZRpxJpNjMj8op-QshN14yljgjMxSjhhznJPNqiyt6QNtS2q2Veu39scVrrG0GLxrPqmr66Fpw9B13obgvu2o2brtt9brbk8fqaYjqVztGu331Nuu9f05OSl1FezFlAuyeV59LF-j9fvL2_JpHe0QoY9KK1IOygAqKySPC-RcF_KvWQ5W5EqnOcRgtIKyKBMGArRB1EylGjDhuCA3_387334NNvRZ7YKxVaUb2w4hkwISiVKM4tUkDnlti6zzrh7rZtMOI7-euA5GV6XXjXHhoKGUKEDhL7UcbR4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76057376</pqid></control><display><type>article</type><title>Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>RUTKAUSKAS, J. S ; DAVIS, J. W</creator><creatorcontrib>RUTKAUSKAS, J. S ; DAVIS, J. W</creatorcontrib><description>Immunosuppressive chemotherapy and bone marrow transplantation are increasingly used to treat and, in some cases, cure numerous malignant conditions. The systemic sequelae as a result of these immunosuppressive techniques lead to a host of oral and dental complications. The direct and indirect stomatotoxic effects lead to development of ulcerative, hemorrhagic, or infectious complications that potentially can lead to increased mortality and morbidity. Chlorhexidine was studied to evaluate its broad spectrum antimicrobial properties and to evaluate its effect on immunosuppression-induced mucositis. Our double-blind randomized study revealed that chlorhexidine versus controls had considerable effect in the bone marrow transplant cohort. Patients who received chlorhexidine while undergoing bone marrow transplantation were found to exhibit fewer and less painful mucositis lesions. This study supports prophylactic use of chlorhexidine in patients who undergo bone marrow transplantation.</description><identifier>ISSN: 0030-4220</identifier><identifier>EISSN: 1878-2175</identifier><identifier>DOI: 10.1016/0030-4220(93)90010-2</identifier><identifier>PMID: 8233423</identifier><identifier>CODEN: OSOMAE</identifier><language>eng</language><publisher>Saint Louis, MO: Mosby</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Bone Marrow Transplantation - adverse effects ; Chemotherapy ; Chlorhexidine - therapeutic use ; Dental Plaque Index ; Dentistry ; Double-Blind Method ; Humans ; Immunosuppressive Agents - adverse effects ; Leukemia - drug therapy ; Medical sciences ; Mouth Mucosa - drug effects ; Mouthwashes - therapeutic use ; Periodontal Index ; Pharmacology. Drug treatments ; Remission Induction ; Stomatitis - drug therapy ; Stomatitis - etiology ; Stomatitis - prevention & control</subject><ispartof>Oral surgery, oral medicine, oral pathology, 1993-10, Vol.76 (4), p.441-448</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3773609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8233423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUTKAUSKAS, J. S</creatorcontrib><creatorcontrib>DAVIS, J. W</creatorcontrib><title>Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report</title><title>Oral surgery, oral medicine, oral pathology</title><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><description>Immunosuppressive chemotherapy and bone marrow transplantation are increasingly used to treat and, in some cases, cure numerous malignant conditions. The systemic sequelae as a result of these immunosuppressive techniques lead to a host of oral and dental complications. The direct and indirect stomatotoxic effects lead to development of ulcerative, hemorrhagic, or infectious complications that potentially can lead to increased mortality and morbidity. Chlorhexidine was studied to evaluate its broad spectrum antimicrobial properties and to evaluate its effect on immunosuppression-induced mucositis. Our double-blind randomized study revealed that chlorhexidine versus controls had considerable effect in the bone marrow transplant cohort. Patients who received chlorhexidine while undergoing bone marrow transplantation were found to exhibit fewer and less painful mucositis lesions. This study supports prophylactic use of chlorhexidine in patients who undergo bone marrow transplantation.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Chemotherapy</subject><subject>Chlorhexidine - therapeutic use</subject><subject>Dental Plaque Index</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Leukemia - drug therapy</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouthwashes - therapeutic use</subject><subject>Periodontal Index</subject><subject>Pharmacology. Drug treatments</subject><subject>Remission Induction</subject><subject>Stomatitis - drug therapy</subject><subject>Stomatitis - etiology</subject><subject>Stomatitis - prevention & control</subject><issn>0030-4220</issn><issn>1878-2175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMo4zj6DxSyENFF9Sa3TRp3MowPGHDjrEuapk6Gvkxacf69FcusDpfv43I4hFwyuGfAxAMAQhRzDrcK7xQAg4gfkTlLZRpxJpNjMj8op-QshN14yljgjMxSjhhznJPNqiyt6QNtS2q2Veu39scVrrG0GLxrPqmr66Fpw9B13obgvu2o2brtt9brbk8fqaYjqVztGu331Nuu9f05OSl1FezFlAuyeV59LF-j9fvL2_JpHe0QoY9KK1IOygAqKySPC-RcF_KvWQ5W5EqnOcRgtIKyKBMGArRB1EylGjDhuCA3_387334NNvRZ7YKxVaUb2w4hkwISiVKM4tUkDnlti6zzrh7rZtMOI7-euA5GV6XXjXHhoKGUKEDhL7UcbR4</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>RUTKAUSKAS, J. S</creator><creator>DAVIS, J. W</creator><general>Mosby</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report</title><author>RUTKAUSKAS, J. S ; DAVIS, J. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j330t-fe68209c039e6724d322ad73423b0e6b9a8b040ca90fdf51060ac33a198a03523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Chemotherapy</topic><topic>Chlorhexidine - therapeutic use</topic><topic>Dental Plaque Index</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Leukemia - drug therapy</topic><topic>Medical sciences</topic><topic>Mouth Mucosa - drug effects</topic><topic>Mouthwashes - therapeutic use</topic><topic>Periodontal Index</topic><topic>Pharmacology. Drug treatments</topic><topic>Remission Induction</topic><topic>Stomatitis - drug therapy</topic><topic>Stomatitis - etiology</topic><topic>Stomatitis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUTKAUSKAS, J. S</creatorcontrib><creatorcontrib>DAVIS, J. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUTKAUSKAS, J. S</au><au>DAVIS, J. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report</atitle><jtitle>Oral surgery, oral medicine, oral pathology</jtitle><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>76</volume><issue>4</issue><spage>441</spage><epage>448</epage><pages>441-448</pages><issn>0030-4220</issn><eissn>1878-2175</eissn><coden>OSOMAE</coden><abstract>Immunosuppressive chemotherapy and bone marrow transplantation are increasingly used to treat and, in some cases, cure numerous malignant conditions. The systemic sequelae as a result of these immunosuppressive techniques lead to a host of oral and dental complications. The direct and indirect stomatotoxic effects lead to development of ulcerative, hemorrhagic, or infectious complications that potentially can lead to increased mortality and morbidity. Chlorhexidine was studied to evaluate its broad spectrum antimicrobial properties and to evaluate its effect on immunosuppression-induced mucositis. Our double-blind randomized study revealed that chlorhexidine versus controls had considerable effect in the bone marrow transplant cohort. Patients who received chlorhexidine while undergoing bone marrow transplantation were found to exhibit fewer and less painful mucositis lesions. This study supports prophylactic use of chlorhexidine in patients who undergo bone marrow transplantation.</abstract><cop>Saint Louis, MO</cop><pub>Mosby</pub><pmid>8233423</pmid><doi>10.1016/0030-4220(93)90010-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0030-4220 |
| ispartof | Oral surgery, oral medicine, oral pathology, 1993-10, Vol.76 (4), p.441-448 |
| issn | 0030-4220 1878-2175 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76057376 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antineoplastic agents Antineoplastic Agents - adverse effects Biological and medical sciences Bone Marrow Transplantation - adverse effects Chemotherapy Chlorhexidine - therapeutic use Dental Plaque Index Dentistry Double-Blind Method Humans Immunosuppressive Agents - adverse effects Leukemia - drug therapy Medical sciences Mouth Mucosa - drug effects Mouthwashes - therapeutic use Periodontal Index Pharmacology. Drug treatments Remission Induction Stomatitis - drug therapy Stomatitis - etiology Stomatitis - prevention & control |
| title | Effects of chlorhexidine during immunosuppressive chemotherapy : a preliminary report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A13%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20chlorhexidine%20during%20immunosuppressive%20chemotherapy%20:%20a%20preliminary%20report&rft.jtitle=Oral%20surgery,%20oral%20medicine,%20oral%20pathology&rft.au=RUTKAUSKAS,%20J.%20S&rft.date=1993-10-01&rft.volume=76&rft.issue=4&rft.spage=441&rft.epage=448&rft.pages=441-448&rft.issn=0030-4220&rft.eissn=1878-2175&rft.coden=OSOMAE&rft_id=info:doi/10.1016/0030-4220(93)90010-2&rft_dat=%3Cproquest_pubme%3E76057376%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76057376&rft_id=info:pmid/8233423&rfr_iscdi=true |