Further Characterization of 4-Bromomisonidazole as a Potential Detector of Hypoxic Cells

$[{}^{14}{\rm C}]\text{Bromomisonidazole}$ was prepared by direct bromination of [ring-2] $[{}^{14}{\rm C}]\text{misonidazole}$ in dioxane. The uptake and binding of the two labeled sensitizers were compared in vitro in 1-mm EMT-6 spheroids which contain a necrotic core. Using liquid scintillation c...

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Veröffentlicht in:	Radiat. Res.; (United States) 1985-04, Vol.102 (1), p.76-85
Hauptverfasser:	Rasey, Janet S., Krohn, Kenneth A., Grunbaum, Zdenka, Conroy, Peter J., Bauer, Kenneth, Sutherland, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	560121 - Radiation Effects on Cells- External Source- (-1987) ALKALI METAL ISOTOPES ANIMAL CELLS Animals ANOXIA ANTINEOPLASTIC DRUGS AUTORADIOGRAPHY AZOLES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences Biological effects of radiation Bromination CARBON 14 COMPOUNDS Carbon Radioisotopes Cell lines CESIUM 137 CESIUM ISOTOPES DETECTION DRUGS ELECTROMAGNETIC RADIATION Flasks Fundamental and applied biological sciences. Psychology GAMMA RADIATION Geometric centers HETEROCYCLIC COMPOUNDS Hypoxia IMIDAZOLES IN VITRO IONIZING RADIATIONS ISOTOPES LABELLED COMPOUNDS Liquids MISONIDAZOLE Misonidazole - analogs & derivatives Misonidazole - metabolism Models, Biological Neoplasms, Experimental - metabolism Nitroimidazoles - metabolism NUCLEI ODD-EVEN NUCLEI ORGANIC BROMINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS Oxygen Radiation dosage RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Sensitizing Agents - metabolism RADIATIONS RADIOISOTOPES RADIOSENSITIVITY EFFECTS RADIOSENSITIZERS Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents Silver Space life sciences SPHEROIDS Tissues, organs and organisms biophysics TUMOR CELLS Tumors UPTAKE YEARS LIVING RADIOISOTOPES
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