Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy
We report an 18-month-old girl with Cushing's disease caused by a large adenoma of the pituitary gland. Tumour size and extension were determined by X-ray, CT-scan and angiographic studies. The endocrinological findings were typical for this disease: elevated plasma levels of ACTH, cortisol, 17...
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| Veröffentlicht in: | European journal of pediatrics 1985, Vol.143 (3), p.221-223 |
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| container_title | European journal of pediatrics |
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| creator | STEGNER, H LÜDECKE, D. K KADRNKA-LOVRENCIC, M STAHNKE, N WILLIG, R. P |
| description | We report an 18-month-old girl with Cushing's disease caused by a large adenoma of the pituitary gland. Tumour size and extension were determined by X-ray, CT-scan and angiographic studies. The endocrinological findings were typical for this disease: elevated plasma levels of ACTH, cortisol, 17-Hydroxyprogesterone (17-OHP) and testosterone, elevated urinary excretion of 17-Ketosteroids (17-KS) and 17-Hydroxycorticoids (17-OHCS). Dexamethasone failed to suppress ACTH and cortisol plasma levels. TRH induced only a minimal TSH increase. Following LH-RH injection gonadotropin levels rose to pubertal values. The hGH response to insulin-induced hypoglycaemia was subnormal. After resection of the tumour the infant died because of non-treatable arrhythmia. Histological findings showed a non-differentiated adenoma with extension into the subarachnoid space and into nerve tissues. In vitro lysine-vasopressin (LVP) and arginine-vasopressin (AVP) exhibited only weak stimulatory effects on the ACTH secretion of the tumour cells. |
| doi_str_mv | 10.1007/BF00442145 |
| format | Article |
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Histological findings showed a non-differentiated adenoma with extension into the subarachnoid space and into nerve tissues. In vitro lysine-vasopressin (LVP) and arginine-vasopressin (AVP) exhibited only weak stimulatory effects on the ACTH secretion of the tumour cells.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/BF00442145</identifier><identifier>PMID: 3987721</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adenoma - complications ; Adenoma - pathology ; Adenoma - surgery ; Biological and medical sciences ; Cushing Syndrome - etiology ; Endocrinopathies ; Female ; Humans ; Hypothalamus. Hypophysis. 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K</creatorcontrib><creatorcontrib>KADRNKA-LOVRENCIC, M</creatorcontrib><creatorcontrib>STAHNKE, N</creatorcontrib><creatorcontrib>WILLIG, R. P</creatorcontrib><title>Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>We report an 18-month-old girl with Cushing's disease caused by a large adenoma of the pituitary gland. Tumour size and extension were determined by X-ray, CT-scan and angiographic studies. The endocrinological findings were typical for this disease: elevated plasma levels of ACTH, cortisol, 17-Hydroxyprogesterone (17-OHP) and testosterone, elevated urinary excretion of 17-Ketosteroids (17-KS) and 17-Hydroxycorticoids (17-OHCS). Dexamethasone failed to suppress ACTH and cortisol plasma levels. TRH induced only a minimal TSH increase. Following LH-RH injection gonadotropin levels rose to pubertal values. The hGH response to insulin-induced hypoglycaemia was subnormal. After resection of the tumour the infant died because of non-treatable arrhythmia. Histological findings showed a non-differentiated adenoma with extension into the subarachnoid space and into nerve tissues. In vitro lysine-vasopressin (LVP) and arginine-vasopressin (AVP) exhibited only weak stimulatory effects on the ACTH secretion of the tumour cells.</description><subject>Adenoma - complications</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Biological and medical sciences</subject><subject>Cushing Syndrome - etiology</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Infant</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - surgery</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oUcREGo5jVpX3LU4VQYeHHnkjbJVuna2TSH_fdGViY8eA--Hx_f-wi5BvYIjOHTy4IxIVIQ2QmZguBpAgzzUzJlXLAkB6XOyYX33yzCCuSETLiSiClMyWoe_KZu1_eemtpb7S01wdKho7qloQ0-6KbZ00b3a0u1sW231bRzdNhYuquHUA-639N1o1tD6zaO0221vyRnTjfeXo17RlaL16_5e7L8fPuYPy-TigMMibIlU7wyLpeiBJtKLdApV4LLJDoNVqRGS5UpyDmik9yUqOORMgTkXPAZuTv47vruJ1g_FNvaV7aJcWwXfIE5y_IMMYIPB7DqO-9764pdX29j9AJY8ddh8d9hhG9G11BurTmiY2lRvx117SvduD6-XPsjpgBTLpH_AsDCd54</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>STEGNER, H</creator><creator>LÜDECKE, D. 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K</creatorcontrib><creatorcontrib>KADRNKA-LOVRENCIC, M</creatorcontrib><creatorcontrib>STAHNKE, N</creatorcontrib><creatorcontrib>WILLIG, R. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STEGNER, H</au><au>LÜDECKE, D. K</au><au>KADRNKA-LOVRENCIC, M</au><au>STAHNKE, N</au><au>WILLIG, R. 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TRH induced only a minimal TSH increase. Following LH-RH injection gonadotropin levels rose to pubertal values. The hGH response to insulin-induced hypoglycaemia was subnormal. After resection of the tumour the infant died because of non-treatable arrhythmia. Histological findings showed a non-differentiated adenoma with extension into the subarachnoid space and into nerve tissues. In vitro lysine-vasopressin (LVP) and arginine-vasopressin (AVP) exhibited only weak stimulatory effects on the ACTH secretion of the tumour cells.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3987721</pmid><doi>10.1007/BF00442145</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0340-6199 |
| ispartof | European journal of pediatrics, 1985, Vol.143 (3), p.221-223 |
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| language | eng |
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| subjects | Adenoma - complications Adenoma - pathology Adenoma - surgery Biological and medical sciences Cushing Syndrome - etiology Endocrinopathies Female Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Infant Malignant tumors Medical sciences Pituitary Neoplasms - complications Pituitary Neoplasms - pathology Pituitary Neoplasms - surgery |
| title | Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy |
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