DNA Recognition by the EcoK Methyltransferase : The Influence of DNA Methylation and the Cofactor S-adenosyl- l-methionine

The methyltransferase of the EcoK type I restriction/modification system is trimeric, M 2S 1, where the S subunit determines the sequence specificity of the enzyme. The methyltransferase has a strong preference for hemimethylated substrate DNA and, therefore, we have investigated the effect of the m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 1993-11, Vol.234 (1), p.60-71
Hauptverfasser:	Powell, Lynn M., Dryden, David T.F., Willcock, Damion F., Pain, Roger H., Murray, Noreen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Analytical, structural and metabolic biochemistry Bacterial Proteins - metabolism Base Sequence Biological and medical sciences DNA methylation DNA-Binding Proteins - metabolism DNA-protein interactions Enzymes and enzyme inhibitors Escherichia coli Fundamental and applied biological sciences. Psychology Hydrolases In Vitro Techniques Kinetics Methylation methyltransferase Molecular Sequence Data Oligodeoxyribonucleotides - metabolism Osmolar Concentration Protein Binding Protein Conformation restriction and modification S-adenosyl- l-methionine S-Adenosylmethionine - metabolism Site-Specific DNA-Methyltransferase (Adenine-Specific) - metabolism Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!