Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 1. Effect of nuclear modification on in vitro activity
The synthesis and biological evaluation of a series of pyrazolidinone-containing mono- and bicyclic compounds are described. The results of this investigation indicate that the [3.3.0] ring system bearing strongly electron-withdrawing groups in the 3-position provides the optimal arrangement for ant...
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| Veröffentlicht in: | Journal of medicinal chemistry 1993-10, Vol.36 (22), p.3219-3223 |
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| container_title | Journal of medicinal chemistry |
| container_volume | 36 |
| creator | Ternansky, Robert J Draheim, Susan E |
| description | The synthesis and biological evaluation of a series of pyrazolidinone-containing mono- and bicyclic compounds are described. The results of this investigation indicate that the [3.3.0] ring system bearing strongly electron-withdrawing groups in the 3-position provides the optimal arrangement for antibacterial activity. Two highly potent derivatives, LY193239 and LY255262, have been selected for further preclinical evaluation. |
| doi_str_mv | 10.1021/jm00074a001 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3219-3223 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76054501 |
| source | ACS Publications; MEDLINE |
| subjects | Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Pyrazoles - chemical synthesis Pyrazoles - pharmacology Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - pharmacology |
| title | Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 1. Effect of nuclear modification on in vitro activity |
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