The Prevalence of Antibodies to Rickettsia rickettsii in an Area Endemic for Rocky Mountain Spotted Fever
A study of Rickettsia rickettsii was conducted in Rowan, Cabarrus, and Granville counties, North Carolina in an attempt to define the prevalence of endemic infection in this area. Serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies...
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| Veröffentlicht in: | The Journal of infectious diseases 1985-05, Vol.151 (5), p.823-831 |
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| creator | Wilfert, Catherine M. MacCormack, J. Newton Kleeman, Karl Philip, Robert N. Austin, Ernest Dickinson, Vivian Turner, Lou |
| description | A study of Rickettsia rickettsii was conducted in Rowan, Cabarrus, and Granville counties, North Carolina in an attempt to define the prevalence of endemic infection in this area. Serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies to R. rickettsii. Of this group, 568 (28.7%) had detectable antibody (⩾1:8), 80 (4%) had titers ⩾1:64, and 1,408 (70%) had no detectable antibody (⩽1:8). Indirect immunofluorescence testing for antibody was also performed for 315 (15%) of the serum samples, of which 301 (95%) had undetectable titers and 14 (5%) had detectable titers ranging from 1:8 to ⩾1:64. Serological reactivity by indirect hemagglutination was detected in persons in the absence of known Rocky Mountain spotted fever. The study failed to show a good correlation of either the height of the geometric mean titer or percentage of seropositive persons with the previously determined age-related rates of acquisition of the disease. These data suggest that the antibodies measured may not be specific for R. rickettsii or that the antibody levels wane with time or both. It is probable that unrecognized infection occurs, but the true incidence or prevalence cannot be determined by available serological tests. |
| doi_str_mv | 10.1093/infdis/151.5.823 |
| format | Article |
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Newton ; Kleeman, Karl ; Philip, Robert N. ; Austin, Ernest ; Dickinson, Vivian ; Turner, Lou</creator><creatorcontrib>Wilfert, Catherine M. ; MacCormack, J. Newton ; Kleeman, Karl ; Philip, Robert N. ; Austin, Ernest ; Dickinson, Vivian ; Turner, Lou</creatorcontrib><description>A study of Rickettsia rickettsii was conducted in Rowan, Cabarrus, and Granville counties, North Carolina in an attempt to define the prevalence of endemic infection in this area. Serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies to R. rickettsii. Of this group, 568 (28.7%) had detectable antibody (⩾1:8), 80 (4%) had titers ⩾1:64, and 1,408 (70%) had no detectable antibody (⩽1:8). Indirect immunofluorescence testing for antibody was also performed for 315 (15%) of the serum samples, of which 301 (95%) had undetectable titers and 14 (5%) had detectable titers ranging from 1:8 to ⩾1:64. Serological reactivity by indirect hemagglutination was detected in persons in the absence of known Rocky Mountain spotted fever. The study failed to show a good correlation of either the height of the geometric mean titer or percentage of seropositive persons with the previously determined age-related rates of acquisition of the disease. These data suggest that the antibodies measured may not be specific for R. rickettsii or that the antibody levels wane with time or both. It is probable that unrecognized infection occurs, but the true incidence or prevalence cannot be determined by available serological tests.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/151.5.823</identifier><identifier>PMID: 3921622</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Age groups ; Antibodies ; Antibodies, Bacterial - analysis ; Antibody Specificity ; Antigens ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Cross sectional studies ; Diseases ; Epidemiology ; Female ; Fluorescent Antibody Technique ; Hemagglutination Tests ; Human bacterial diseases ; Humans ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; North Carolina ; Original Articles ; Reactivity ; Rickettsia rickettsii ; Rickettsia rickettsii - immunology ; Rickettsial diseases ; Rocky Mountain spotted fever ; Rocky Mountain Spotted Fever - epidemiology ; Rocky Mountain Spotted Fever - immunology ; Surveillance ; Tropical bacterial diseases ; Tropical medicine</subject><ispartof>The Journal of infectious diseases, 1985-05, Vol.151 (5), p.823-831</ispartof><rights>Copyright 1985 The University of Chicago</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-8941397268912ae2fb228210822d3ab49eb6d37da91bd3ea315f8f64a865de153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30135953$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30135953$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9181047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3921622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilfert, Catherine M.</creatorcontrib><creatorcontrib>MacCormack, J. Newton</creatorcontrib><creatorcontrib>Kleeman, Karl</creatorcontrib><creatorcontrib>Philip, Robert N.</creatorcontrib><creatorcontrib>Austin, Ernest</creatorcontrib><creatorcontrib>Dickinson, Vivian</creatorcontrib><creatorcontrib>Turner, Lou</creatorcontrib><title>The Prevalence of Antibodies to Rickettsia rickettsii in an Area Endemic for Rocky Mountain Spotted Fever</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A study of Rickettsia rickettsii was conducted in Rowan, Cabarrus, and Granville counties, North Carolina in an attempt to define the prevalence of endemic infection in this area. Serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies to R. rickettsii. Of this group, 568 (28.7%) had detectable antibody (⩾1:8), 80 (4%) had titers ⩾1:64, and 1,408 (70%) had no detectable antibody (⩽1:8). Indirect immunofluorescence testing for antibody was also performed for 315 (15%) of the serum samples, of which 301 (95%) had undetectable titers and 14 (5%) had detectable titers ranging from 1:8 to ⩾1:64. Serological reactivity by indirect hemagglutination was detected in persons in the absence of known Rocky Mountain spotted fever. The study failed to show a good correlation of either the height of the geometric mean titer or percentage of seropositive persons with the previously determined age-related rates of acquisition of the disease. These data suggest that the antibodies measured may not be specific for R. rickettsii or that the antibody levels wane with time or both. It is probable that unrecognized infection occurs, but the true incidence or prevalence cannot be determined by available serological tests.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Age groups</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Antibody Specificity</subject><subject>Antigens</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross sectional studies</subject><subject>Diseases</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Hemagglutination Tests</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>North Carolina</subject><subject>Original Articles</subject><subject>Reactivity</subject><subject>Rickettsia rickettsii</subject><subject>Rickettsia rickettsii - immunology</subject><subject>Rickettsial diseases</subject><subject>Rocky Mountain spotted fever</subject><subject>Rocky Mountain Spotted Fever - epidemiology</subject><subject>Rocky Mountain Spotted Fever - immunology</subject><subject>Surveillance</subject><subject>Tropical bacterial diseases</subject><subject>Tropical medicine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EKmngzgXJB8RtU3-vfYyqliIVUUqQKi6Wdz0r3GzWwXYq-t_XVdL2yGksvd97I79B6AMlC0oMPwnT4EM-oZIu5EIz_grNqORtoxTlr9GMEMYaqo15i45zviWECK7aI3TEDaOKsRkKqz-ArxLcuRGmHnAc8HIqoYs-QMYl4uvQr6GUHBxOT8-Aw4TdhJcJHD6bPGxCj4eY8HXs1_f4W9xNxVXk5zaWAh6fwx2kd-jN4MYM7w9zjn6dn61OL5rL71--ni4vm15QURptBOWmZUobyhywoWNMM0o0Y567ThjolOetd4Z2noPjVA56UMJpJT3Uz8_R533uNsW_O8jFbkLuYRzdBHGXbauIFJz_H6Si1iprqXNE9mCfYs4JBrtNYePSvaXEPp7B7s9gK2-lrY5q-XjI3nUb8M-GQ-9V_3TQXe7dOCQ39TXgCTNUUyLal5jbXGJ6SSGUSyMf1zR7PeQC_551l9ZWtbyV9uLmt9VX7Y-VuOGW8QfuQ6lN</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Wilfert, Catherine M.</creator><creator>MacCormack, J. Newton</creator><creator>Kleeman, Karl</creator><creator>Philip, Robert N.</creator><creator>Austin, Ernest</creator><creator>Dickinson, Vivian</creator><creator>Turner, Lou</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>The Prevalence of Antibodies to Rickettsia rickettsii in an Area Endemic for Rocky Mountain Spotted Fever</title><author>Wilfert, Catherine M. ; MacCormack, J. Newton ; Kleeman, Karl ; Philip, Robert N. ; Austin, Ernest ; Dickinson, Vivian ; Turner, Lou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-8941397268912ae2fb228210822d3ab49eb6d37da91bd3ea315f8f64a865de153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Age groups</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Antibody Specificity</topic><topic>Antigens</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross sectional studies</topic><topic>Diseases</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Hemagglutination Tests</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>North Carolina</topic><topic>Original Articles</topic><topic>Reactivity</topic><topic>Rickettsia rickettsii</topic><topic>Rickettsia rickettsii - immunology</topic><topic>Rickettsial diseases</topic><topic>Rocky Mountain spotted fever</topic><topic>Rocky Mountain Spotted Fever - epidemiology</topic><topic>Rocky Mountain Spotted Fever - immunology</topic><topic>Surveillance</topic><topic>Tropical bacterial diseases</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilfert, Catherine M.</creatorcontrib><creatorcontrib>MacCormack, J. Newton</creatorcontrib><creatorcontrib>Kleeman, Karl</creatorcontrib><creatorcontrib>Philip, Robert N.</creatorcontrib><creatorcontrib>Austin, Ernest</creatorcontrib><creatorcontrib>Dickinson, Vivian</creatorcontrib><creatorcontrib>Turner, Lou</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilfert, Catherine M.</au><au>MacCormack, J. Newton</au><au>Kleeman, Karl</au><au>Philip, Robert N.</au><au>Austin, Ernest</au><au>Dickinson, Vivian</au><au>Turner, Lou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Prevalence of Antibodies to Rickettsia rickettsii in an Area Endemic for Rocky Mountain Spotted Fever</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1985-05</date><risdate>1985</risdate><volume>151</volume><issue>5</issue><spage>823</spage><epage>831</epage><pages>823-831</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>A study of Rickettsia rickettsii was conducted in Rowan, Cabarrus, and Granville counties, North Carolina in an attempt to define the prevalence of endemic infection in this area. Serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies to R. rickettsii. Of this group, 568 (28.7%) had detectable antibody (⩾1:8), 80 (4%) had titers ⩾1:64, and 1,408 (70%) had no detectable antibody (⩽1:8). Indirect immunofluorescence testing for antibody was also performed for 315 (15%) of the serum samples, of which 301 (95%) had undetectable titers and 14 (5%) had detectable titers ranging from 1:8 to ⩾1:64. Serological reactivity by indirect hemagglutination was detected in persons in the absence of known Rocky Mountain spotted fever. The study failed to show a good correlation of either the height of the geometric mean titer or percentage of seropositive persons with the previously determined age-related rates of acquisition of the disease. These data suggest that the antibodies measured may not be specific for R. rickettsii or that the antibody levels wane with time or both. It is probable that unrecognized infection occurs, but the true incidence or prevalence cannot be determined by available serological tests.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3921622</pmid><doi>10.1093/infdis/151.5.823</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1985-05, Vol.151 (5), p.823-831 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adolescent Adult Age Factors Age groups Antibodies Antibodies, Bacterial - analysis Antibody Specificity Antigens Bacterial diseases Biological and medical sciences Child Child, Preschool Cross sectional studies Diseases Epidemiology Female Fluorescent Antibody Technique Hemagglutination Tests Human bacterial diseases Humans Infant Infant, Newborn Infections Infectious diseases Male Medical sciences Middle Aged North Carolina Original Articles Reactivity Rickettsia rickettsii Rickettsia rickettsii - immunology Rickettsial diseases Rocky Mountain spotted fever Rocky Mountain Spotted Fever - epidemiology Rocky Mountain Spotted Fever - immunology Surveillance Tropical bacterial diseases Tropical medicine |
| title | The Prevalence of Antibodies to Rickettsia rickettsii in an Area Endemic for Rocky Mountain Spotted Fever |
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