Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis and adrenergic activity of isochroman derivatives

In previous papers dealing with the study of the conformations and the biopharmacological activity of conformationally restrained analogs of sympathomimetic catecholamines (NE and ISO), proposals were advanced for the three-dimensional molecular models A, B, and C; these models provided information...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-10, Vol.36 (21), p.3077-3086
Hauptverfasser:	Macchia, Bruno, Balsamo, Aldo, Breschi, Maria Cristina, Chiellini, Grazia, Lapucci, Annalina, Macchia, Marco, Manera, Clementina, Martinelli, Adriano, Martini, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catecholamines - chemical synthesis Catecholamines - chemistry Catecholamines - pharmacology Chemistry Exact sciences and technology Guinea Pigs Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Male Models, Molecular Molecular Conformation Muscle, Smooth - drug effects Norepinephrine - analogs & derivatives Organic chemistry Preparations and properties Rats Rats, Sprague-Dawley Stereoisomerism Structure-Activity Relationship Sympathomimetics - chemical synthesis Sympathomimetics - chemistry Sympathomimetics - pharmacology
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