Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury
The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no e...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1985-04, Vol.228 (4698), p.497-499 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 499 |
|---|---|
| container_issue | 4698 |
| container_start_page | 497 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 228 |
| creator | Giulian, Dana Lachman, Lawrence B. |
| description | The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin-2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin-1 was detected in brains of adult rats 10 days after the brains had been injured. These findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain. |
| doi_str_mv | 10.1126/science.3872478 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76053529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A3742510</galeid><jstor_id>1694742</jstor_id><sourcerecordid>A3742510</sourcerecordid><originalsourceid>FETCH-LOGICAL-c706t-a3e2f6a3cc94bf607e7c646eab5c06636a7417d16998496225b854de88f90383</originalsourceid><addsrcrecordid>eNqN0s9r2zAUB3AxNrq023mXDXwY26FzK1m2ZB3TsKWBsAxadjWK8mSUyVIn2bD-99WwaTsILOgg0PejX7yH0DuCLwgp2GVUBpyCC1rzouT1CzQjWFS5KDB9iWYYU5bXmFev0WmMe4xTJugJOpn4DF2vXA_BwvDLuJxkN73pBit7413mdTaPffCtNdJmP4K3RkMYM6nTruwqSOOyldsP4f4NeqWljfB2ms_Q7bevt4vrfL1Zrhbzda44Zn0uKRSaSaqUKLeaYQ5csZKB3FYKM0aZ5CXhO8KEqEvBiqLa1lW5g7rWAtOanqFP47F3wf8eIPZNZ6ICa6UDP8SGM1zRqhD_haQkRDBSJXg-wlZaaIzTvg9SteDSX613oE1anlNeFhXBSX85oNPYQWfUAf75H55ED3_6Vg4xNqub78fKzc9j5dXySFkv18_l-SGpvLXQQpMquNg815ejVsHHGEA3d8F0Mtw3BDd_27KZ2rKZ-izt-DBVY9h2sHv0T_nHKZdRSauDdMrER1aXXPCCJPZ-ZPvY-_B0KxNlehp9ALgL8B8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14119615</pqid></control><display><type>article</type><title>Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Giulian, Dana ; Lachman, Lawrence B.</creator><creatorcontrib>Giulian, Dana ; Lachman, Lawrence B.</creatorcontrib><description>The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin-2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin-1 was detected in brains of adult rats 10 days after the brains had been injured. These findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3872478</identifier><identifier>PMID: 3872478</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Animals ; Animals, Newborn ; Astrocytes ; Astrocytes - pathology ; Biological and medical sciences ; Brain ; Brain damage ; Brain injuries ; Brain Injuries - pathology ; Cell growth ; Cells, Cultured ; Chromatography, High Pressure Liquid - methods ; Chromatography, Ion Exchange - methods ; Cultured cells ; Fundamental and applied biological sciences. Psychology ; Glia ; Interleukin-1 ; Interleukin-1 - isolation & purification ; Interleukin-1 - physiology ; Interleukin-2 - physiology ; Interleukins ; Isoelectric Focusing ; Isolated neuron and nerve. Neuroglia ; Laboratory rats ; Mitogens ; Neuroglia ; Oligodendroglia ; Oligodendroglia - pathology ; Rats ; Rats as laboratory animals ; Thymocytes ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1985-04, Vol.228 (4698), p.497-499</ispartof><rights>Copyright 1985 The American Association for the Advancement of Science</rights><rights>1986 INIST-CNRS</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1985 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-a3e2f6a3cc94bf607e7c646eab5c06636a7417d16998496225b854de88f90383</citedby><cites>FETCH-LOGICAL-c706t-a3e2f6a3cc94bf607e7c646eab5c06636a7417d16998496225b854de88f90383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1694742$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1694742$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8479721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3872478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giulian, Dana</creatorcontrib><creatorcontrib>Lachman, Lawrence B.</creatorcontrib><title>Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin-2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin-1 was detected in brains of adult rats 10 days after the brains had been injured. These findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Astrocytes</subject><subject>Astrocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain injuries</subject><subject>Brain Injuries - pathology</subject><subject>Cell growth</subject><subject>Cells, Cultured</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Cultured cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glia</subject><subject>Interleukin-1</subject><subject>Interleukin-1 - isolation & purification</subject><subject>Interleukin-1 - physiology</subject><subject>Interleukin-2 - physiology</subject><subject>Interleukins</subject><subject>Isoelectric Focusing</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Laboratory rats</subject><subject>Mitogens</subject><subject>Neuroglia</subject><subject>Oligodendroglia</subject><subject>Oligodendroglia - pathology</subject><subject>Rats</subject><subject>Rats as laboratory animals</subject><subject>Thymocytes</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9r2zAUB3AxNrq023mXDXwY26FzK1m2ZB3TsKWBsAxadjWK8mSUyVIn2bD-99WwaTsILOgg0PejX7yH0DuCLwgp2GVUBpyCC1rzouT1CzQjWFS5KDB9iWYYU5bXmFev0WmMe4xTJugJOpn4DF2vXA_BwvDLuJxkN73pBit7413mdTaPffCtNdJmP4K3RkMYM6nTruwqSOOyldsP4f4NeqWljfB2ms_Q7bevt4vrfL1Zrhbzda44Zn0uKRSaSaqUKLeaYQ5csZKB3FYKM0aZ5CXhO8KEqEvBiqLa1lW5g7rWAtOanqFP47F3wf8eIPZNZ6ICa6UDP8SGM1zRqhD_haQkRDBSJXg-wlZaaIzTvg9SteDSX613oE1anlNeFhXBSX85oNPYQWfUAf75H55ED3_6Vg4xNqub78fKzc9j5dXySFkv18_l-SGpvLXQQpMquNg815ejVsHHGEA3d8F0Mtw3BDd_27KZ2rKZ-izt-DBVY9h2sHv0T_nHKZdRSauDdMrER1aXXPCCJPZ-ZPvY-_B0KxNlehp9ALgL8B8</recordid><startdate>19850426</startdate><enddate>19850426</enddate><creator>Giulian, Dana</creator><creator>Lachman, Lawrence B.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850426</creationdate><title>Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury</title><author>Giulian, Dana ; Lachman, Lawrence B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c706t-a3e2f6a3cc94bf607e7c646eab5c06636a7417d16998496225b854de88f90383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Astrocytes</topic><topic>Astrocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain damage</topic><topic>Brain injuries</topic><topic>Brain Injuries - pathology</topic><topic>Cell growth</topic><topic>Cells, Cultured</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Cultured cells</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glia</topic><topic>Interleukin-1</topic><topic>Interleukin-1 - isolation & purification</topic><topic>Interleukin-1 - physiology</topic><topic>Interleukin-2 - physiology</topic><topic>Interleukins</topic><topic>Isoelectric Focusing</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Laboratory rats</topic><topic>Mitogens</topic><topic>Neuroglia</topic><topic>Oligodendroglia</topic><topic>Oligodendroglia - pathology</topic><topic>Rats</topic><topic>Rats as laboratory animals</topic><topic>Thymocytes</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giulian, Dana</creatorcontrib><creatorcontrib>Lachman, Lawrence B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giulian, Dana</au><au>Lachman, Lawrence B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1985-04-26</date><risdate>1985</risdate><volume>228</volume><issue>4698</issue><spage>497</spage><epage>499</epage><pages>497-499</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin-2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin-1 was detected in brains of adult rats 10 days after the brains had been injured. These findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3872478</pmid><doi>10.1126/science.3872478</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1985-04, Vol.228 (4698), p.497-499 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76053529 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Animals, Newborn Astrocytes Astrocytes - pathology Biological and medical sciences Brain Brain damage Brain injuries Brain Injuries - pathology Cell growth Cells, Cultured Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange - methods Cultured cells Fundamental and applied biological sciences. Psychology Glia Interleukin-1 Interleukin-1 - isolation & purification Interleukin-1 - physiology Interleukin-2 - physiology Interleukins Isoelectric Focusing Isolated neuron and nerve. Neuroglia Laboratory rats Mitogens Neuroglia Oligodendroglia Oligodendroglia - pathology Rats Rats as laboratory animals Thymocytes Vertebrates: nervous system and sense organs |
| title | Interleukin-1 Stimulation of Astroglial Proliferation after Brain Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T15%3A03%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-1%20Stimulation%20of%20Astroglial%20Proliferation%20after%20Brain%20Injury&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Giulian,%20Dana&rft.date=1985-04-26&rft.volume=228&rft.issue=4698&rft.spage=497&rft.epage=499&rft.pages=497-499&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.3872478&rft_dat=%3Cgale_proqu%3EA3742510%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14119615&rft_id=info:pmid/3872478&rft_galeid=A3742510&rft_jstor_id=1694742&rfr_iscdi=true |