The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol
1. The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat. 2. Isoproterenol significantly increases ventricular automaticity even with the lo...
Gespeichert in:
| Veröffentlicht in: | General pharmacology 1985, Vol.16 (1), p.65-67 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 67 |
|---|---|
| container_issue | 1 |
| container_start_page | 65 |
| container_title | General pharmacology |
| container_volume | 16 |
| creator | Laorden, M.L. Hernández, J. Brugger, A.J. |
| description | 1. The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat.
2. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10
−9 M).
3. Tulobuterol, at concentrations ranging from 10
−9 M to 10
−6 M do not induce any change on the automatic ventricular frequency.
4. Nevertheless, at higher concentrations (10
−5 and 5 × 10
−5 M), tulobuterol decreases the experimentally induced ventricular automaticity.
5. Our results suggest that the new beta-agonist drug tulobuterol does not increase ventricular automaticity but, in fact, decreases it. |
| doi_str_mv | 10.1016/0306-3623(85)90272-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76052783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0306362385902721</els_id><sourcerecordid>76052783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-135a49b53268383c008bc68a61d533bb3dd024a2221703e91ea8ec1aab3580c33</originalsourceid><addsrcrecordid>eNqFUc9LHDEUDkWx67b_QQs5lXoYfUkmM9kehLLYVhC86Dm8SZ4amZlsk0zF_97Z7uJRT-_B9wu-j7EvAk4FiOYMFDSVaqT6bvTJCmQrK_GBLYRpVxWAEAds8Ur5yI5zfgQAqaU8YkfSaFMrWLDHmwfiHRWs8D6OIRfu03TPy9THbiqUYs89uUSYKXOHyQd0HKcSByzBhfLMw8jL7JGw_ODrOGwwhRxH_hTKA5-_TYqzDY2x_8QO77DP9Hl_l-z218XN-k91df37cv3zqnLKmFIJpbFedVrJxiijHIDpXGOwEV4r1XXKe5A1SilFC4pWgtCQE4id0gacUkv2bec7R_-dKBc7hOyo73GkOGXbNqBla94nilq2bW3amVjviC7FnBPd2U0KA6ZnK8But7Dbou22aGu0_b-FFbPs695_6gbyr6J9-TN-vsNpbuNfoGSzCzQ68iGRK9bH8HbAC7sVmRU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14277487</pqid></control><display><type>article</type><title>The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Laorden, M.L. ; Hernández, J. ; Brugger, A.J.</creator><creatorcontrib>Laorden, M.L. ; Hernández, J. ; Brugger, A.J.</creatorcontrib><description>1. The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat.
2. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10
−9 M).
3. Tulobuterol, at concentrations ranging from 10
−9 M to 10
−6 M do not induce any change on the automatic ventricular frequency.
4. Nevertheless, at higher concentrations (10
−5 and 5 × 10
−5 M), tulobuterol decreases the experimentally induced ventricular automaticity.
5. Our results suggest that the new beta-agonist drug tulobuterol does not increase ventricular automaticity but, in fact, decreases it.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(85)90272-1</identifier><identifier>PMID: 2858430</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adrenergic beta-Agonists - pharmacology ; Animals ; Arrhythmias, Cardiac - physiopathology ; Female ; Heart - drug effects ; In Vitro Techniques ; Isoproterenol - pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Terbutaline - analogs & derivatives ; Terbutaline - pharmacology ; Time Factors</subject><ispartof>General pharmacology, 1985, Vol.16 (1), p.65-67</ispartof><rights>1985</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-135a49b53268383c008bc68a61d533bb3dd024a2221703e91ea8ec1aab3580c33</citedby><cites>FETCH-LOGICAL-c388t-135a49b53268383c008bc68a61d533bb3dd024a2221703e91ea8ec1aab3580c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2858430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laorden, M.L.</creatorcontrib><creatorcontrib>Hernández, J.</creatorcontrib><creatorcontrib>Brugger, A.J.</creatorcontrib><title>The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1. The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat.
2. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10
−9 M).
3. Tulobuterol, at concentrations ranging from 10
−9 M to 10
−6 M do not induce any change on the automatic ventricular frequency.
4. Nevertheless, at higher concentrations (10
−5 and 5 × 10
−5 M), tulobuterol decreases the experimentally induced ventricular automaticity.
5. Our results suggest that the new beta-agonist drug tulobuterol does not increase ventricular automaticity but, in fact, decreases it.</description><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Female</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Terbutaline - analogs & derivatives</subject><subject>Terbutaline - pharmacology</subject><subject>Time Factors</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUc9LHDEUDkWx67b_QQs5lXoYfUkmM9kehLLYVhC86Dm8SZ4amZlsk0zF_97Z7uJRT-_B9wu-j7EvAk4FiOYMFDSVaqT6bvTJCmQrK_GBLYRpVxWAEAds8Ur5yI5zfgQAqaU8YkfSaFMrWLDHmwfiHRWs8D6OIRfu03TPy9THbiqUYs89uUSYKXOHyQd0HKcSByzBhfLMw8jL7JGw_ODrOGwwhRxH_hTKA5-_TYqzDY2x_8QO77DP9Hl_l-z218XN-k91df37cv3zqnLKmFIJpbFedVrJxiijHIDpXGOwEV4r1XXKe5A1SilFC4pWgtCQE4id0gacUkv2bec7R_-dKBc7hOyo73GkOGXbNqBla94nilq2bW3amVjviC7FnBPd2U0KA6ZnK8But7Dbou22aGu0_b-FFbPs695_6gbyr6J9-TN-vsNpbuNfoGSzCzQ68iGRK9bH8HbAC7sVmRU</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Laorden, M.L.</creator><creator>Hernández, J.</creator><creator>Brugger, A.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol</title><author>Laorden, M.L. ; Hernández, J. ; Brugger, A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-135a49b53268383c008bc68a61d533bb3dd024a2221703e91ea8ec1aab3580c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Female</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Terbutaline - analogs & derivatives</topic><topic>Terbutaline - pharmacology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Laorden, M.L.</creatorcontrib><creatorcontrib>Hernández, J.</creatorcontrib><creatorcontrib>Brugger, A.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laorden, M.L.</au><au>Hernández, J.</au><au>Brugger, A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>16</volume><issue>1</issue><spage>65</spage><epage>67</epage><pages>65-67</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><abstract>1. The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat.
2. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10
−9 M).
3. Tulobuterol, at concentrations ranging from 10
−9 M to 10
−6 M do not induce any change on the automatic ventricular frequency.
4. Nevertheless, at higher concentrations (10
−5 and 5 × 10
−5 M), tulobuterol decreases the experimentally induced ventricular automaticity.
5. Our results suggest that the new beta-agonist drug tulobuterol does not increase ventricular automaticity but, in fact, decreases it.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>2858430</pmid><doi>10.1016/0306-3623(85)90272-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-3623 |
| ispartof | General pharmacology, 1985, Vol.16 (1), p.65-67 |
| issn | 0306-3623 1879-0011 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76052783 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Agonists - pharmacology Animals Arrhythmias, Cardiac - physiopathology Female Heart - drug effects In Vitro Techniques Isoproterenol - pharmacology Male Rats Rats, Inbred Strains Terbutaline - analogs & derivatives Terbutaline - pharmacology Time Factors |
| title | The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: Comparison with isoproterenol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T21%3A15%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20beta-agonist%20drug%20tulobuterol%20decreases%20cardiac%20automaticity%20in%20the%20rat:%20Comparison%20with%20isoproterenol&rft.jtitle=General%20pharmacology&rft.au=Laorden,%20M.L.&rft.date=1985&rft.volume=16&rft.issue=1&rft.spage=65&rft.epage=67&rft.pages=65-67&rft.issn=0306-3623&rft.eissn=1879-0011&rft_id=info:doi/10.1016/0306-3623(85)90272-1&rft_dat=%3Cproquest_cross%3E76052783%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14277487&rft_id=info:pmid/2858430&rft_els_id=0306362385902721&rfr_iscdi=true |