Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure
The proteolytic enzyme, chymase, was used to identify mast cells in rat gastrocnemius muscles which were crush-injured or incised in order to determine if mast cells exhibited proliferation and degranulation. Some of the crush-injured rats were subjected to 0 g for 14 days after injury on the Cosmos...
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| Veröffentlicht in: | Experimental and molecular pathology 1993-10, Vol.59 (2), p.87-94 |
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| creator | Stauber, W.T. Fritz, V.K. Burkovskaya, T.E. Ilyina-Kakueva, E.I. |
| description | The proteolytic enzyme, chymase, was used to identify mast cells in rat gastrocnemius muscles which were crush-injured or incised in order to determine if mast cells exhibited proliferation and degranulation. Some of the crush-injured rats were subjected to 0 g for 14 days after injury on the Cosmos 2044 satellite to study the effects of weightlessness on the mast cell response. A variety of ground-based injured models were used, including a group of hindlimb-unloaded animals acting as controls and testing the suitability of the hindlimb-unloaded animal as a model for muscle healing during weightlessness. In most cases, the numbers of mast cells and their apparent size increased after injury. When mast cell degranulation was evident, the granules containing chymase often were free in the loose connective tissue and along the edge of myofibers. The mast cell response was most exaggerated in animals subjected to 0 g and least visible in the hindlimb-unloaded ones. Thus, gravitational stress may influence mast cell physiology and the hindlimb-unloaded animal may not be a good model for investigating muscle healing. |
| doi_str_mv | 10.1006/exmp.1993.1030 |
| format | Article |
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Some of the crush-injured rats were subjected to 0 g for 14 days after injury on the Cosmos 2044 satellite to study the effects of weightlessness on the mast cell response. A variety of ground-based injured models were used, including a group of hindlimb-unloaded animals acting as controls and testing the suitability of the hindlimb-unloaded animal as a model for muscle healing during weightlessness. In most cases, the numbers of mast cells and their apparent size increased after injury. When mast cell degranulation was evident, the granules containing chymase often were free in the loose connective tissue and along the edge of myofibers. The mast cell response was most exaggerated in animals subjected to 0 g and least visible in the hindlimb-unloaded ones. Thus, gravitational stress may influence mast cell physiology and the hindlimb-unloaded animal may not be a good model for investigating muscle healing.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1006/exmp.1993.1030</identifier><identifier>PMID: 8224116</identifier><identifier>CODEN: EXMPA6</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Division ; Chymases ; Cytoplasmic Granules - enzymology ; Cytoplasmic Granules - ultrastructure ; Fluorescent Antibody Technique ; Gravitation ; Immunohistochemistry ; Injuries of the limb. Injuries of the spine ; Male ; Mast Cells - enzymology ; Mast Cells - pathology ; Mast Cells - physiology ; Medical sciences ; Models, Biological ; Muscles - enzymology ; Muscles - pathology ; Muscles - physiology ; Rats ; Rats, Sprague-Dawley ; Russia ; Serine Endopeptidases - analysis ; Space Flight ; Space life sciences ; Traumas. Diseases due to physical agents ; Weightlessness</subject><ispartof>Experimental and molecular pathology, 1993-10, Vol.59 (2), p.87-94</ispartof><rights>1993 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-c58eb4328e73541685c2e74f32157d4430407c96e6c6aa8e787d94625a7e1e793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/exmp.1993.1030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3886580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8224116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stauber, W.T.</creatorcontrib><creatorcontrib>Fritz, V.K.</creatorcontrib><creatorcontrib>Burkovskaya, T.E.</creatorcontrib><creatorcontrib>Ilyina-Kakueva, E.I.</creatorcontrib><title>Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>The proteolytic enzyme, chymase, was used to identify mast cells in rat gastrocnemius muscles which were crush-injured or incised in order to determine if mast cells exhibited proliferation and degranulation. Some of the crush-injured rats were subjected to 0 g for 14 days after injury on the Cosmos 2044 satellite to study the effects of weightlessness on the mast cell response. A variety of ground-based injured models were used, including a group of hindlimb-unloaded animals acting as controls and testing the suitability of the hindlimb-unloaded animal as a model for muscle healing during weightlessness. In most cases, the numbers of mast cells and their apparent size increased after injury. When mast cell degranulation was evident, the granules containing chymase often were free in the loose connective tissue and along the edge of myofibers. The mast cell response was most exaggerated in animals subjected to 0 g and least visible in the hindlimb-unloaded ones. Thus, gravitational stress may influence mast cell physiology and the hindlimb-unloaded animal may not be a good model for investigating muscle healing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Chymases</subject><subject>Cytoplasmic Granules - enzymology</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Fluorescent Antibody Technique</subject><subject>Gravitation</subject><subject>Immunohistochemistry</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Male</subject><subject>Mast Cells - enzymology</subject><subject>Mast Cells - pathology</subject><subject>Mast Cells - physiology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Muscles - enzymology</subject><subject>Muscles - pathology</subject><subject>Muscles - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Russia</subject><subject>Serine Endopeptidases - analysis</subject><subject>Space Flight</subject><subject>Space life sciences</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Weightlessness</subject><issn>0014-4800</issn><issn>1096-0945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFP3DAQRi1EBVvg2huSD6i3bMex4zhHtNpukUCVUDlbxpmoRkkcbAeWf19Hu-LWkzUzz59mHiHfGKwZgPyB-2Fas6bhueRwQlYMGllAI6pTsgJgohAK4Jx8jfEFABpg5Rk5U2UpGJMrYrZdhzZR39G78WUOH9SP9MHERDfY93HpP5pEd7kTvB1xcHOkD3O0PdJ3l_7SR4zTEpA83QXz5pJJzo-mp9v95OMc8JJ86Uwf8er4XpCnn9s_m1_F_e_d3eb2vrBcqlTYSuGz4KXCmleCSVXZEmvR8ZJVdSsEBwG1bSRKK43JlKrbRsiyMjUyrBt-Qb4fcqfgX2eMSQ8u2nyEGdHPUdcSKshcBtcH0AYfY8BOT8ENJnxoBnpxqhenenGqF6f5w_UxeX4esP3EjxLz_OY4N9GavgtmtC5-YlwpWaklRh0wzBbeHAYdrcPRYutCNqhb7_63wT-oX5Gr</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Stauber, W.T.</creator><creator>Fritz, V.K.</creator><creator>Burkovskaya, T.E.</creator><creator>Ilyina-Kakueva, E.I.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure</title><author>Stauber, W.T. ; Fritz, V.K. ; Burkovskaya, T.E. ; Ilyina-Kakueva, E.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-c58eb4328e73541685c2e74f32157d4430407c96e6c6aa8e787d94625a7e1e793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Chymases</topic><topic>Cytoplasmic Granules - enzymology</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>Fluorescent Antibody Technique</topic><topic>Gravitation</topic><topic>Immunohistochemistry</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Male</topic><topic>Mast Cells - enzymology</topic><topic>Mast Cells - pathology</topic><topic>Mast Cells - physiology</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Muscles - enzymology</topic><topic>Muscles - pathology</topic><topic>Muscles - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Russia</topic><topic>Serine Endopeptidases - analysis</topic><topic>Space Flight</topic><topic>Space life sciences</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Weightlessness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stauber, W.T.</creatorcontrib><creatorcontrib>Fritz, V.K.</creatorcontrib><creatorcontrib>Burkovskaya, T.E.</creatorcontrib><creatorcontrib>Ilyina-Kakueva, E.I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stauber, W.T.</au><au>Fritz, V.K.</au><au>Burkovskaya, T.E.</au><au>Ilyina-Kakueva, E.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure</atitle><jtitle>Experimental and molecular pathology</jtitle><addtitle>Exp Mol Pathol</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>59</volume><issue>2</issue><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>0014-4800</issn><eissn>1096-0945</eissn><coden>EXMPA6</coden><abstract>The proteolytic enzyme, chymase, was used to identify mast cells in rat gastrocnemius muscles which were crush-injured or incised in order to determine if mast cells exhibited proliferation and degranulation. Some of the crush-injured rats were subjected to 0 g for 14 days after injury on the Cosmos 2044 satellite to study the effects of weightlessness on the mast cell response. A variety of ground-based injured models were used, including a group of hindlimb-unloaded animals acting as controls and testing the suitability of the hindlimb-unloaded animal as a model for muscle healing during weightlessness. In most cases, the numbers of mast cells and their apparent size increased after injury. When mast cell degranulation was evident, the granules containing chymase often were free in the loose connective tissue and along the edge of myofibers. The mast cell response was most exaggerated in animals subjected to 0 g and least visible in the hindlimb-unloaded ones. Thus, gravitational stress may influence mast cell physiology and the hindlimb-unloaded animal may not be a good model for investigating muscle healing.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8224116</pmid><doi>10.1006/exmp.1993.1030</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Division Chymases Cytoplasmic Granules - enzymology Cytoplasmic Granules - ultrastructure Fluorescent Antibody Technique Gravitation Immunohistochemistry Injuries of the limb. Injuries of the spine Male Mast Cells - enzymology Mast Cells - pathology Mast Cells - physiology Medical sciences Models, Biological Muscles - enzymology Muscles - pathology Muscles - physiology Rats Rats, Sprague-Dawley Russia Serine Endopeptidases - analysis Space Flight Space life sciences Traumas. Diseases due to physical agents Weightlessness |
| title | Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure |
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