GABA-gated chloride ion influx in brains of tremor rats
We measured the GABA-gated chloride ion influx and GABA concentrations in the cerebral cortex and the hippocampus of young (5 weeks old) and older (15 weeks old) tremor rats. GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15...
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| Veröffentlicht in: | Neurochemical research 1993-09, Vol.18 (9), p.977-981 |
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| container_title | Neurochemical research |
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| creator | KISHI, K ITO, M TSUDA, A TSUDA, H SHIRAISHI, H SEJIMA, H MORI, C SERIKAWA, T YAMADA, J |
| description | We measured the GABA-gated chloride ion influx and GABA concentrations in the cerebral cortex and the hippocampus of young (5 weeks old) and older (15 weeks old) tremor rats. GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15 week-old groups. GABA concentrations in the cerebral cortex and hippocampus of the tremor rats increased compared with controls of 5 weeks and decreased compared with controls of 15 weeks. These findings suggest that the GABAergic presynaptic neurons in the cortex and hippocampus of the tremor rat are disturbed with aging. This change may be related to the appearance of absence-like seizures in the rats. The increased GABA-gated chloride ion influx in tremor rats may be a compensatory mechanism against the genetically-determined seizure susceptibility of these rats. Furthermore, the increased GABA levels and GABA-gated chloride ion influx found in 5 week-old tremor rats may be related to the tremor movements. |
| doi_str_mv | 10.1007/bf00966756 |
| format | Article |
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GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15 week-old groups. GABA concentrations in the cerebral cortex and hippocampus of the tremor rats increased compared with controls of 5 weeks and decreased compared with controls of 15 weeks. These findings suggest that the GABAergic presynaptic neurons in the cortex and hippocampus of the tremor rat are disturbed with aging. This change may be related to the appearance of absence-like seizures in the rats. The increased GABA-gated chloride ion influx in tremor rats may be a compensatory mechanism against the genetically-determined seizure susceptibility of these rats. Furthermore, the increased GABA levels and GABA-gated chloride ion influx found in 5 week-old tremor rats may be related to the tremor movements.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/bf00966756</identifier><identifier>PMID: 8232726</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Cerebral Cortex - metabolism ; Chlorides - metabolism ; Epilepsy, Absence - metabolism ; Frontal Lobe - metabolism ; gamma-Aminobutyric Acid - physiology ; Hippocampus - metabolism ; Ion Channel Gating - physiology ; Medical sciences ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neurons - physiology ; Occipital Lobe - metabolism ; Parietal Lobe - metabolism ; Rats ; Rats, Mutant Strains ; Temporal Lobe - metabolism ; Tremor - metabolism</subject><ispartof>Neurochemical research, 1993-09, Vol.18 (9), p.977-981</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-3295ce62d798f460cea861bff8c3219c2df0e1c8c35e9162e777ed3623fd07e63</citedby><cites>FETCH-LOGICAL-c408t-3295ce62d798f460cea861bff8c3219c2df0e1c8c35e9162e777ed3623fd07e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4922041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8232726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KISHI, K</creatorcontrib><creatorcontrib>ITO, M</creatorcontrib><creatorcontrib>TSUDA, A</creatorcontrib><creatorcontrib>TSUDA, H</creatorcontrib><creatorcontrib>SHIRAISHI, H</creatorcontrib><creatorcontrib>SEJIMA, H</creatorcontrib><creatorcontrib>MORI, C</creatorcontrib><creatorcontrib>SERIKAWA, T</creatorcontrib><creatorcontrib>YAMADA, J</creatorcontrib><title>GABA-gated chloride ion influx in brains of tremor rats</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>We measured the GABA-gated chloride ion influx and GABA concentrations in the cerebral cortex and the hippocampus of young (5 weeks old) and older (15 weeks old) tremor rats. GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15 week-old groups. GABA concentrations in the cerebral cortex and hippocampus of the tremor rats increased compared with controls of 5 weeks and decreased compared with controls of 15 weeks. These findings suggest that the GABAergic presynaptic neurons in the cortex and hippocampus of the tremor rat are disturbed with aging. This change may be related to the appearance of absence-like seizures in the rats. The increased GABA-gated chloride ion influx in tremor rats may be a compensatory mechanism against the genetically-determined seizure susceptibility of these rats. Furthermore, the increased GABA levels and GABA-gated chloride ion influx found in 5 week-old tremor rats may be related to the tremor movements.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cerebral Cortex - metabolism</subject><subject>Chlorides - metabolism</subject><subject>Epilepsy, Absence - metabolism</subject><subject>Frontal Lobe - metabolism</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Hippocampus - metabolism</subject><subject>Ion Channel Gating - physiology</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Neurons - physiology</subject><subject>Occipital Lobe - metabolism</subject><subject>Parietal Lobe - metabolism</subject><subject>Rats</subject><subject>Rats, Mutant Strains</subject><subject>Temporal Lobe - metabolism</subject><subject>Tremor - metabolism</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMoc04v3oUexINQ_ZK0SXPshpvCwIueS5p-0Up_zKQF_e-NrO7q6eXlfXgPDyGXFO4ogLwvLYASQqbiiMxpKnksFPBjMgcukphTBafkzPsPgIAzOiOzjHEmmZgTucmXefymB6wi8970rq4wqvsuqjvbjF8hotLpuvNRb6PBYdu7yOnBn5MTqxuPF1MuyOv64WX1GG-fN0-rfBubBLIh5kylBgWrpMpsIsCgzgQtrc0MZ1QZVllAakJLUVHBUEqJFReM2wokCr4gN_vfnes_R_RD0dbeYNPoDvvRF1JAkomM_gvSoIcqngTwdg8a13vv0BY7V7fafRcUil-dxXL9pzPAV9PrWLZYHdDJX9ivp117oxvrdGdqf8ASxRgklP8AqSV51g</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>KISHI, K</creator><creator>ITO, M</creator><creator>TSUDA, A</creator><creator>TSUDA, H</creator><creator>SHIRAISHI, H</creator><creator>SEJIMA, H</creator><creator>MORI, C</creator><creator>SERIKAWA, T</creator><creator>YAMADA, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>GABA-gated chloride ion influx in brains of tremor rats</title><author>KISHI, K ; ITO, M ; TSUDA, A ; TSUDA, H ; SHIRAISHI, H ; SEJIMA, H ; MORI, C ; SERIKAWA, T ; YAMADA, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3295ce62d798f460cea861bff8c3219c2df0e1c8c35e9162e777ed3623fd07e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cerebral Cortex - metabolism</topic><topic>Chlorides - metabolism</topic><topic>Epilepsy, Absence - metabolism</topic><topic>Frontal Lobe - metabolism</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Hippocampus - metabolism</topic><topic>Ion Channel Gating - physiology</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Neurons - physiology</topic><topic>Occipital Lobe - metabolism</topic><topic>Parietal Lobe - metabolism</topic><topic>Rats</topic><topic>Rats, Mutant Strains</topic><topic>Temporal Lobe - metabolism</topic><topic>Tremor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KISHI, K</creatorcontrib><creatorcontrib>ITO, M</creatorcontrib><creatorcontrib>TSUDA, A</creatorcontrib><creatorcontrib>TSUDA, H</creatorcontrib><creatorcontrib>SHIRAISHI, H</creatorcontrib><creatorcontrib>SEJIMA, H</creatorcontrib><creatorcontrib>MORI, C</creatorcontrib><creatorcontrib>SERIKAWA, T</creatorcontrib><creatorcontrib>YAMADA, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KISHI, K</au><au>ITO, M</au><au>TSUDA, A</au><au>TSUDA, H</au><au>SHIRAISHI, H</au><au>SEJIMA, H</au><au>MORI, C</au><au>SERIKAWA, T</au><au>YAMADA, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GABA-gated chloride ion influx in brains of tremor rats</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>18</volume><issue>9</issue><spage>977</spage><epage>981</epage><pages>977-981</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>We measured the GABA-gated chloride ion influx and GABA concentrations in the cerebral cortex and the hippocampus of young (5 weeks old) and older (15 weeks old) tremor rats. GABA-gated chloride ion influx in these tremor rats was significantly greater than in the controls of both the 5 week- and 15 week-old groups. GABA concentrations in the cerebral cortex and hippocampus of the tremor rats increased compared with controls of 5 weeks and decreased compared with controls of 15 weeks. These findings suggest that the GABAergic presynaptic neurons in the cortex and hippocampus of the tremor rat are disturbed with aging. This change may be related to the appearance of absence-like seizures in the rats. The increased GABA-gated chloride ion influx in tremor rats may be a compensatory mechanism against the genetically-determined seizure susceptibility of these rats. Furthermore, the increased GABA levels and GABA-gated chloride ion influx found in 5 week-old tremor rats may be related to the tremor movements.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>8232726</pmid><doi>10.1007/bf00966756</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Brain - metabolism Cerebral Cortex - metabolism Chlorides - metabolism Epilepsy, Absence - metabolism Frontal Lobe - metabolism gamma-Aminobutyric Acid - physiology Hippocampus - metabolism Ion Channel Gating - physiology Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons - physiology Occipital Lobe - metabolism Parietal Lobe - metabolism Rats Rats, Mutant Strains Temporal Lobe - metabolism Tremor - metabolism |
| title | GABA-gated chloride ion influx in brains of tremor rats |
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