First-phase insulin release in normal children
Normal values for the first-phase insulin release during an intravenous glucosetolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative isl...
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| Veröffentlicht in: | The Journal of pediatrics 1993-11, Vol.123 (5), p.733-738 |
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| container_end_page | 738 |
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| container_issue | 5 |
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| container_title | The Journal of pediatrics |
| container_volume | 123 |
| creator | Allen, H.F. Jeffers, B.W. Klingensmith, G.J. Chase, H.P. |
| description | Normal values for the first-phase insulin release during an intravenous glucosetolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (±SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93±10.1 mIU/L; 11 to 15 years, 172.7±22.3 mIU/L; and 16 to 22 years, 163±28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with firstphase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults. |
| doi_str_mv | 10.1016/S0022-3476(05)80847-9 |
| format | Article |
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In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (±SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93±10.1 mIU/L; 11 to 15 years, 172.7±22.3 mIU/L; and 16 to 22 years, 163±28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with firstphase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(05)80847-9</identifier><identifier>PMID: 8229481</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Body Mass Index ; Child ; Endocrine pancreas ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Hormones. 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In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (±SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93±10.1 mIU/L; 11 to 15 years, 172.7±22.3 mIU/L; and 16 to 22 years, 163±28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with firstphase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Endocrine pancreas</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Hormones. Régulation</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Vertebrates: endocrinology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-hEIOInpInf3I7uYkUqwKBQ_qedlsJnQlTepuKvjvTZvSq6dhmOedGR5CphRmFKi8fwdgLOVCyVvI7jRoodL8hIwp5CqVmvNTMj4i5-Qixi8AyAXAiIw0Y7nQdExmCx9il25WNmLim7itfZMErHHok6YNa1snbuXrMmBzSc4qW0e8OtQJ-Vw8fcxf0uXb8-v8cZk6oUWXSsod08wyWTGskEJR5QUTSmHBlXRMlGCdykopbaGxoCxjvHS05DzP8oxTPiE3w95NaL-3GDuz9tFhXdsG2200SoLQGegezAbQhTbGgJXZBL-24ddQMDtPZu_J7CQYyMzek8n73PRwYFussTymDmL6-fVhbqOzdRVs43w8YlxpLgTvsYcBw17Gj8dgovPYOCx9QNeZsvX_PPIH4fKCsA</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Allen, H.F.</creator><creator>Jeffers, B.W.</creator><creator>Klingensmith, G.J.</creator><creator>Chase, H.P.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931101</creationdate><title>First-phase insulin release in normal children</title><author>Allen, H.F. ; Jeffers, B.W. ; Klingensmith, G.J. ; Chase, H.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-613c282a26f2efe10bf9b2477eb376c24d0ac75d66ab8eb12523dc1d339595313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Endocrine pancreas</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Hormones. Régulation</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, H.F.</creatorcontrib><creatorcontrib>Jeffers, B.W.</creatorcontrib><creatorcontrib>Klingensmith, G.J.</creatorcontrib><creatorcontrib>Chase, H.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, H.F.</au><au>Jeffers, B.W.</au><au>Klingensmith, G.J.</au><au>Chase, H.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-phase insulin release in normal children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>123</volume><issue>5</issue><spage>733</spage><epage>738</epage><pages>733-738</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Normal values for the first-phase insulin release during an intravenous glucosetolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (±SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93±10.1 mIU/L; 11 to 15 years, 172.7±22.3 mIU/L; and 16 to 22 years, 163±28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with firstphase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8229481</pmid><doi>10.1016/S0022-3476(05)80847-9</doi><tpages>6</tpages></addata></record> |
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| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Age Factors Biological and medical sciences Body Mass Index Child Endocrine pancreas Female Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Hormones. Régulation Humans Insulin - blood Male Reference Values Reproducibility of Results Vertebrates: endocrinology |
| title | First-phase insulin release in normal children |
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