Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils ( Meriones unguiculatus)
A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils ( Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-μm segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1....
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| Veröffentlicht in: | European journal of pharmacology 1993-09, Vol.241 (1), p.89-97 |
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| container_title | European journal of pharmacology |
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| creator | Dawirs, Ralph R. Teuchert-Noodt, Gertraud Molthagen, Martin |
| description | A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (
Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-μm segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system. |
| doi_str_mv | 10.1016/0014-2999(93)90937-D |
| format | Article |
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Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-μm segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(93)90937-D</identifier><identifier>PMID: 8223930</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Dendrites - drug effects ; Dendritic spine density ; Gerbil ; Gerbillinae ; Histocytochemistry ; Male ; Medical sciences ; Meriones unguiculatus ; Methamphetamine ; Methamphetamine - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Prefrontal cortex ; Prefrontal Cortex - cytology ; Prefrontal Cortex - drug effects ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Pyramidal Cells - drug effects ; Reactive synaptogenesis ; Synapses - drug effects</subject><ispartof>European journal of pharmacology, 1993-09, Vol.241 (1), p.89-97</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c7be83950af6f6a3137f507db145a6ee92b7b394330971471c5a31033ee663c53</citedby><cites>FETCH-LOGICAL-c417t-c7be83950af6f6a3137f507db145a6ee92b7b394330971471c5a31033ee663c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001429999390937D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4915503$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8223930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dawirs, Ralph R.</creatorcontrib><creatorcontrib>Teuchert-Noodt, Gertraud</creatorcontrib><creatorcontrib>Molthagen, Martin</creatorcontrib><title>Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils ( Meriones unguiculatus)</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (
Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-μm segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dendrites - drug effects</subject><subject>Dendritic spine density</subject><subject>Gerbil</subject><subject>Gerbillinae</subject><subject>Histocytochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meriones unguiculatus</subject><subject>Methamphetamine</subject><subject>Methamphetamine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - cytology</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Pyramidal Cells - drug effects</subject><subject>Reactive synaptogenesis</subject><subject>Synapses - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxa0KVLZLv0GRfECoPQTsOLbXl0qo_6hUxIWeLceZ7BoldrCdivLp6-2u9ginOczvPc28h9AZJZ8poeILIbSpaqXUuWIXiigmq-sjtKArqSoiaf0GLQ7IO3SS0i9CCFc1P0bHq7pmipEF-nvvO2dNdsHj0OMR8saM0wayGZ2HyvluttDhCMZm9wQ4PXsz5bAGD8kl7DzOG8BThD4Gn82AbYgZ_my91hBbNyR8jr9DLP6Q8OzXs7PzYPKcLt6jt70ZEpzu5xI93t78vPpWPfy4u7_6-lDZhspcWdnCiilOTC96YRhlsudEdi1tuBEAqm5ly1TDGFGSNpJaXiDCGIAQzHK2RJ92vlMMv2dIWY8uWRgG4yHMSUtBiorT_4JUSCmYVAVsdqCNIaXyu56iG0181pTobTd6G7zeBq8V06_d6Osi-7D3n9sRuoNoX0bZf9zvTbJm6KPx1qUD1ijKeflriS53GJTQnhxEnawDX2pyEWzWXXD_vuMFgfKsGQ</recordid><startdate>19930907</startdate><enddate>19930907</enddate><creator>Dawirs, Ralph R.</creator><creator>Teuchert-Noodt, Gertraud</creator><creator>Molthagen, Martin</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930907</creationdate><title>Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils ( Meriones unguiculatus)</title><author>Dawirs, Ralph R. ; Teuchert-Noodt, Gertraud ; Molthagen, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c7be83950af6f6a3137f507db145a6ee92b7b394330971471c5a31033ee663c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dendrites - drug effects</topic><topic>Dendritic spine density</topic><topic>Gerbil</topic><topic>Gerbillinae</topic><topic>Histocytochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meriones unguiculatus</topic><topic>Methamphetamine</topic><topic>Methamphetamine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - cytology</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Pyramidal Cells - drug effects</topic><topic>Reactive synaptogenesis</topic><topic>Synapses - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawirs, Ralph R.</creatorcontrib><creatorcontrib>Teuchert-Noodt, Gertraud</creatorcontrib><creatorcontrib>Molthagen, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawirs, Ralph R.</au><au>Teuchert-Noodt, Gertraud</au><au>Molthagen, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils ( Meriones unguiculatus)</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1993-09-07</date><risdate>1993</risdate><volume>241</volume><issue>1</issue><spage>89</spage><epage>97</epage><pages>89-97</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (
Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-μm segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8223930</pmid><doi>10.1016/0014-2999(93)90937-D</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Dendrites - drug effects Dendritic spine density Gerbil Gerbillinae Histocytochemistry Male Medical sciences Meriones unguiculatus Methamphetamine Methamphetamine - pharmacology Neuropharmacology Pharmacology. Drug treatments Prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - drug effects Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyramidal Cells - drug effects Reactive synaptogenesis Synapses - drug effects |
| title | Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils ( Meriones unguiculatus) |
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