The acute effects of cigarette smoke exposure on experimental skin flaps
Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure prot...
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| Veröffentlicht in: | Plast. Reconstr. Surg.; (United States) 1985-04, Vol.75 (4), p.544-549 |
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| container_title | Plast. Reconstr. Surg.; (United States) |
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| creator | Nolan, J Jenkins, R A Kurihara, K Schultz, R C |
| description | Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study. |
| doi_str_mv | 10.1097/00006534-198504000-00018 |
| format | Article |
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Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.</description><identifier>ISSN: 0032-1052</identifier><identifier>DOI: 10.1097/00006534-198504000-00018</identifier><identifier>PMID: 3983255</identifier><language>eng</language><publisher>United States</publisher><subject>550900 - Pathology ; 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ; AEROSOLS ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BIOLOGICAL MODELS ; BODY ; COLLOIDS ; DATA ; DISPERSIONS ; EXPERIMENTAL DATA ; Female ; INFORMATION ; INHALATION ; INTAKE ; MAMMALS ; MEDICINE ; NECROSIS ; Necrosis - etiology ; NUMERICAL DATA ; ORGANS ; PATHOGENESIS ; PATHOLOGICAL CHANGES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RATS ; Rats, Inbred F344 ; RESIDUES ; RISK ASSESSMENT ; RODENTS ; SKIN ; SMOKES ; Smoking ; SOLS ; SURGERY ; Surgical Flaps ; TOBACCO SMOKES ; TOXICITY ; VERTEBRATES ; Wound Healing</subject><ispartof>Plast. 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Reconstr. Surg.; (United States)</title><addtitle>Plast Reconstr Surg</addtitle><description>Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.</description><subject>550900 - Pathology</subject><subject>560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)</subject><subject>AEROSOLS</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOLOGICAL MODELS</subject><subject>BODY</subject><subject>COLLOIDS</subject><subject>DATA</subject><subject>DISPERSIONS</subject><subject>EXPERIMENTAL DATA</subject><subject>Female</subject><subject>INFORMATION</subject><subject>INHALATION</subject><subject>INTAKE</subject><subject>MAMMALS</subject><subject>MEDICINE</subject><subject>NECROSIS</subject><subject>Necrosis - etiology</subject><subject>NUMERICAL DATA</subject><subject>ORGANS</subject><subject>PATHOGENESIS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RATS</subject><subject>Rats, Inbred F344</subject><subject>RESIDUES</subject><subject>RISK ASSESSMENT</subject><subject>RODENTS</subject><subject>SKIN</subject><subject>SMOKES</subject><subject>Smoking</subject><subject>SOLS</subject><subject>SURGERY</subject><subject>Surgical Flaps</subject><subject>TOBACCO SMOKES</subject><subject>TOXICITY</subject><subject>VERTEBRATES</subject><subject>Wound Healing</subject><issn>0032-1052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhnMAjTH4CUgRB26FfDRJc0QTMKRJXMY5ylKHlbXNaFIJ_j0ZG7MU2bFfJ_aDEKbknhKtHkg2KXhZUF0JUuZbkQ-tztCUEM4KSgS7QJcxfuas4lJM0ITrijMhpmix2gC2bkyAwXtwKeLgsWs-7AApJ2MXtrn0vQtxHACHfh_D0HTQJ9viuG167Fu7i1fo3Ns2wvXRz9D789NqviiWby-v88dl4UrOUqGol06Wzim15tRpBkR6rbhntfMg6opUzuY6owI0WA1gWVWDsrKWjNGaz9Dt4d0QU2OiaxK4jQt9n2c3QslMQmfR3UG0G8LXCDGZrokO2tb2EMZolCSlFCXJwuogdEOIcQBvdnk3O_wYSsyervmna050zR_d3Hpz_GNcd1CfGo9o-S-4y3dW</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Nolan, J</creator><creator>Jenkins, R A</creator><creator>Kurihara, K</creator><creator>Schultz, R C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198504</creationdate><title>The acute effects of cigarette smoke exposure on experimental skin flaps</title><author>Nolan, J ; Jenkins, R A ; Kurihara, K ; Schultz, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-71f6c64cc77b31c92e06f973f2dcfe5d808ca64c215e9ea9eea28de7a6d6221d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>550900 - Pathology</topic><topic>560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)</topic><topic>AEROSOLS</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOLOGICAL MODELS</topic><topic>BODY</topic><topic>COLLOIDS</topic><topic>DATA</topic><topic>DISPERSIONS</topic><topic>EXPERIMENTAL DATA</topic><topic>Female</topic><topic>INFORMATION</topic><topic>INHALATION</topic><topic>INTAKE</topic><topic>MAMMALS</topic><topic>MEDICINE</topic><topic>NECROSIS</topic><topic>Necrosis - etiology</topic><topic>NUMERICAL DATA</topic><topic>ORGANS</topic><topic>PATHOGENESIS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RATS</topic><topic>Rats, Inbred F344</topic><topic>RESIDUES</topic><topic>RISK ASSESSMENT</topic><topic>RODENTS</topic><topic>SKIN</topic><topic>SMOKES</topic><topic>Smoking</topic><topic>SOLS</topic><topic>SURGERY</topic><topic>Surgical Flaps</topic><topic>TOBACCO SMOKES</topic><topic>TOXICITY</topic><topic>VERTEBRATES</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nolan, J</creatorcontrib><creatorcontrib>Jenkins, R A</creatorcontrib><creatorcontrib>Kurihara, K</creatorcontrib><creatorcontrib>Schultz, R C</creatorcontrib><creatorcontrib>Univ. of Illinois Medical Center, Chicago</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Plast. Reconstr. Surg.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nolan, J</au><au>Jenkins, R A</au><au>Kurihara, K</au><au>Schultz, R C</au><aucorp>Univ. of Illinois Medical Center, Chicago</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The acute effects of cigarette smoke exposure on experimental skin flaps</atitle><jtitle>Plast. Reconstr. Surg.; (United States)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>1985-04</date><risdate>1985</risdate><volume>75</volume><issue>4</issue><spage>544</spage><epage>549</epage><pages>544-549</pages><issn>0032-1052</issn><abstract>Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.</abstract><cop>United States</cop><pmid>3983255</pmid><doi>10.1097/00006534-198504000-00018</doi><tpages>6</tpages></addata></record> |
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| ispartof | Plast. Reconstr. Surg.; (United States), 1985-04, Vol.75 (4), p.544-549 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | 550900 - Pathology 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) AEROSOLS ANIMALS BASIC BIOLOGICAL SCIENCES BIOLOGICAL MODELS BODY COLLOIDS DATA DISPERSIONS EXPERIMENTAL DATA Female INFORMATION INHALATION INTAKE MAMMALS MEDICINE NECROSIS Necrosis - etiology NUMERICAL DATA ORGANS PATHOGENESIS PATHOLOGICAL CHANGES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred F344 RESIDUES RISK ASSESSMENT RODENTS SKIN SMOKES Smoking SOLS SURGERY Surgical Flaps TOBACCO SMOKES TOXICITY VERTEBRATES Wound Healing |
| title | The acute effects of cigarette smoke exposure on experimental skin flaps |
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