Examination of Anti‐Neutrophil Cytoplasmic Antibodies in Childhood Inflammatory Bowel Disease
Summary The detection of anti‐neutrophil cytoplasmic antibodies (ANCA), in a perinuclear fluorescence pattern, in the serum of adults with inflammatory bowel disease has recently been described to be sensitive and specific for a diagnosis of ulcerative colitis in comparison to Crohn's disease a...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1993-08, Vol.17 (2), p.193-197 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Proujansky, Roy Fawcett, Paul T. Gibney, Kathleen M. Treem, William R. Hyams, Jeffrey S. |
| description | Summary
The detection of anti‐neutrophil cytoplasmic antibodies (ANCA), in a perinuclear fluorescence pattern, in the serum of adults with inflammatory bowel disease has recently been described to be sensitive and specific for a diagnosis of ulcerative colitis in comparison to Crohn's disease and other colitides. We have examined the sera of 41 children and adolescents with ulcerative colitis, 27 with Crohn's disease, and a control group for the presence of ANCA. Anti‐neutrophil cytoplasmic antibodies were detected in the serum of 27 of 41 patients with ulcerative colitis (66%), five of 27 with Crohn's disease (19%), and in none of our control subjects or patients with functional abdominal pain. Overall, the presence of ANCA was 66% sensitive and 84% specific for a diagnosis of ulcerative colitis when compared to Crohn's disease. There was no relationship between a positive ANCA value and disease activity or other clinical indicators. We conclude that evaluation for the presence of ANCA may be a useful adjunct for the clinical assessment of patients with inflammatory bowel disease. The presence of ANCA in children and adolescents, however, will not definitively distinguish between patients with ulcerative colitis and Crohn's disease. |
| doi_str_mv | 10.1002/j.1536-4801.1993.tb10946.x |
| format | Article |
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The detection of anti‐neutrophil cytoplasmic antibodies (ANCA), in a perinuclear fluorescence pattern, in the serum of adults with inflammatory bowel disease has recently been described to be sensitive and specific for a diagnosis of ulcerative colitis in comparison to Crohn's disease and other colitides. We have examined the sera of 41 children and adolescents with ulcerative colitis, 27 with Crohn's disease, and a control group for the presence of ANCA. Anti‐neutrophil cytoplasmic antibodies were detected in the serum of 27 of 41 patients with ulcerative colitis (66%), five of 27 with Crohn's disease (19%), and in none of our control subjects or patients with functional abdominal pain. Overall, the presence of ANCA was 66% sensitive and 84% specific for a diagnosis of ulcerative colitis when compared to Crohn's disease. There was no relationship between a positive ANCA value and disease activity or other clinical indicators. We conclude that evaluation for the presence of ANCA may be a useful adjunct for the clinical assessment of patients with inflammatory bowel disease. The presence of ANCA in children and adolescents, however, will not definitively distinguish between patients with ulcerative colitis and Crohn's disease.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1993.tb10946.x</identifier><identifier>PMID: 8229547</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Adult ; Antineutrophil cytoplasmic antibody ; Anti‐nuclear antibody ; Autoantibodies - blood ; Biological and medical sciences ; Chi-Square Distribution ; Child ; Child, Preschool ; Colitis, Ulcerative - immunology ; Crohn Disease - immunology ; Crohn's disease ; Cytoplasm - immunology ; Fluorescent Antibody Technique ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Inflammatory Bowel Diseases - immunology ; Medical sciences ; Neutrophils - immunology ; Neutrophils - ultrastructure ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Ulcerative colitis</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1993-08, Vol.17 (2), p.193-197</ispartof><rights>1993 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Lippincott-Raven Publishers.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2931-8f30b25006233fb63215bb4bb3a8ade78908306bfa66c169ae263ea7a0ecbc0c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4905819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8229547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Proujansky, Roy</creatorcontrib><creatorcontrib>Fawcett, Paul T.</creatorcontrib><creatorcontrib>Gibney, Kathleen M.</creatorcontrib><creatorcontrib>Treem, William R.</creatorcontrib><creatorcontrib>Hyams, Jeffrey S.</creatorcontrib><title>Examination of Anti‐Neutrophil Cytoplasmic Antibodies in Childhood Inflammatory Bowel Disease</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Summary
The detection of anti‐neutrophil cytoplasmic antibodies (ANCA), in a perinuclear fluorescence pattern, in the serum of adults with inflammatory bowel disease has recently been described to be sensitive and specific for a diagnosis of ulcerative colitis in comparison to Crohn's disease and other colitides. We have examined the sera of 41 children and adolescents with ulcerative colitis, 27 with Crohn's disease, and a control group for the presence of ANCA. Anti‐neutrophil cytoplasmic antibodies were detected in the serum of 27 of 41 patients with ulcerative colitis (66%), five of 27 with Crohn's disease (19%), and in none of our control subjects or patients with functional abdominal pain. Overall, the presence of ANCA was 66% sensitive and 84% specific for a diagnosis of ulcerative colitis when compared to Crohn's disease. There was no relationship between a positive ANCA value and disease activity or other clinical indicators. We conclude that evaluation for the presence of ANCA may be a useful adjunct for the clinical assessment of patients with inflammatory bowel disease. The presence of ANCA in children and adolescents, however, will not definitively distinguish between patients with ulcerative colitis and Crohn's disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antineutrophil cytoplasmic antibody</subject><subject>Anti‐nuclear antibody</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Crohn Disease - immunology</subject><subject>Crohn's disease</subject><subject>Cytoplasm - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - immunology</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - ultrastructure</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Ulcerative colitis</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcGO0zAQhi0EWrqFR0CKEOKWMLYTJ-FWyi4sWi0c4GyNXUd1ceJiJ2p74xF4Rp6EZBv1zmE0tv7_94w-E_KaQkYB2LtdRgsu0rwCmtG65lmvKNS5yI5PyOIiPSULYGWZMkrFc3Id4w4AyryAK3JVMVYXebkg8uaIre2wt75LfJOsut7-_f3nwQx98Putdcn61Pu9w9ha_agqv7EmJrZL1qO82Xq_Se66xmHbYu_DKfngD8YlH200GM0L8qxBF83LuS_Jj9ub7-vP6f3XT3fr1X2qWc1pWjUcFCsABOO8UYIzWiiVK8Wxwo0pqxoqDkI1KISmokbDBDdYIhitNGi-JG_P7-6D_zWY2MvWRm2cw874IcpSQM6rsZbk_dmog48xmEbug20xnCQFOdGVOzkhlBNCOdGVM115HMOv5imDas3mEp1xjvqbWceo0TUBO23jxZbXUFS0Hm352Xbwrjch_nTDwQS5Nej6rRx_CQpainQaDtV4S8eidIyt5ph15vQfe8sv3x7445n_A2m5qQ0</recordid><startdate>199308</startdate><enddate>199308</enddate><creator>Proujansky, Roy</creator><creator>Fawcett, Paul T.</creator><creator>Gibney, Kathleen M.</creator><creator>Treem, William R.</creator><creator>Hyams, Jeffrey S.</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199308</creationdate><title>Examination of Anti‐Neutrophil Cytoplasmic Antibodies in Childhood Inflammatory Bowel Disease</title><author>Proujansky, Roy ; Fawcett, Paul T. ; Gibney, Kathleen M. ; Treem, William R. ; Hyams, Jeffrey S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2931-8f30b25006233fb63215bb4bb3a8ade78908306bfa66c169ae263ea7a0ecbc0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antineutrophil cytoplasmic antibody</topic><topic>Anti‐nuclear antibody</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Colitis, Ulcerative - immunology</topic><topic>Crohn Disease - immunology</topic><topic>Crohn's disease</topic><topic>Cytoplasm - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - immunology</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - ultrastructure</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Proujansky, Roy</creatorcontrib><creatorcontrib>Fawcett, Paul T.</creatorcontrib><creatorcontrib>Gibney, Kathleen M.</creatorcontrib><creatorcontrib>Treem, William R.</creatorcontrib><creatorcontrib>Hyams, Jeffrey S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proujansky, Roy</au><au>Fawcett, Paul T.</au><au>Gibney, Kathleen M.</au><au>Treem, William R.</au><au>Hyams, Jeffrey S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of Anti‐Neutrophil Cytoplasmic Antibodies in Childhood Inflammatory Bowel Disease</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1993-08</date><risdate>1993</risdate><volume>17</volume><issue>2</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Summary
The detection of anti‐neutrophil cytoplasmic antibodies (ANCA), in a perinuclear fluorescence pattern, in the serum of adults with inflammatory bowel disease has recently been described to be sensitive and specific for a diagnosis of ulcerative colitis in comparison to Crohn's disease and other colitides. We have examined the sera of 41 children and adolescents with ulcerative colitis, 27 with Crohn's disease, and a control group for the presence of ANCA. Anti‐neutrophil cytoplasmic antibodies were detected in the serum of 27 of 41 patients with ulcerative colitis (66%), five of 27 with Crohn's disease (19%), and in none of our control subjects or patients with functional abdominal pain. Overall, the presence of ANCA was 66% sensitive and 84% specific for a diagnosis of ulcerative colitis when compared to Crohn's disease. There was no relationship between a positive ANCA value and disease activity or other clinical indicators. We conclude that evaluation for the presence of ANCA may be a useful adjunct for the clinical assessment of patients with inflammatory bowel disease. The presence of ANCA in children and adolescents, however, will not definitively distinguish between patients with ulcerative colitis and Crohn's disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8229547</pmid><doi>10.1002/j.1536-4801.1993.tb10946.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Antineutrophil cytoplasmic antibody Anti‐nuclear antibody Autoantibodies - blood Biological and medical sciences Chi-Square Distribution Child Child, Preschool Colitis, Ulcerative - immunology Crohn Disease - immunology Crohn's disease Cytoplasm - immunology Fluorescent Antibody Technique Gastroenterology. Liver. Pancreas. Abdomen Humans Inflammatory Bowel Diseases - immunology Medical sciences Neutrophils - immunology Neutrophils - ultrastructure Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Ulcerative colitis |
| title | Examination of Anti‐Neutrophil Cytoplasmic Antibodies in Childhood Inflammatory Bowel Disease |
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