Effect of hirudin on platelet deposition to an artificial surface during low-stress shear flow of whole blood

The effect of hirudin, a known inhibitor of thrombin, was evaluated for whole blood samples in terms of platelet deposition/adhesion to a non-biological test surface (tetrafluoroethylene-propylene copolymer), adenosine diphosphate (ADP) release and reduction in platelet count during laminar shear fl...

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Veröffentlicht in:	Biomaterials 1993-09, Vol.14 (11), p.865-870
Hauptverfasser:	Alkhamis, Taha M., Beissinger, Richard L., Chediak, Juan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism artificial surface Biocompatible Materials Blood Flow Velocity Hemolysis hirudin Hirudins - pharmacology Humans Platelet adhesion Platelet Adhesiveness - drug effects platelet aggregation Platelet Aggregation - drug effects Platelet Count - drug effects Polymers Polytetrafluoroethylene shear flow thrombin Viscosity
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