Prolonged disruption of plasma β-endorphin dynamics following surgery
The purpose of the present study was to examine the effects of surgery on plasma β-endorphin dynamics. Plasma β-endorphin levels were measured by liquid chromatography/radioimmunoassay in seven patients undergoing elective surgery. Blood samples were obtained every 4 hr for two 24-hr periods: one be...
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| Veröffentlicht in: | The Journal of surgical research 1985-01, Vol.38 (3), p.210-215 |
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| container_title | The Journal of surgical research |
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| creator | McIntosh, Tracy K. Bush, Harry L. Palter, Marc Hay, James R. Aun, Frederico Yeston, Neil S. Egdahl, Richard H. |
| description | The purpose of the present study was to examine the effects of surgery on plasma β-endorphin dynamics. Plasma β-endorphin levels were measured by liquid chromatography/radioimmunoassay in seven patients undergoing elective surgery. Blood samples were obtained every 4 hr for two 24-hr periods: one beginning 48 hr before surgery and the other beginning 48 hr after surgery. Computer analysis of β-endorphin levels as a function of clock time demonstrated a true circadian rhythm preoperatively with a mean of 28.0 ± 5.9 pg/ml. In the postoperative period mean β-endorphin levels were significantly elevated (85.6 ± 20.7 pg/ml,
P < 0.005). Surgical procedures caused significant phase shifting in the grouped mean circadian rhythm of plasma β-endorphin (mean = 2.4 hr). When the data was analyzed individually, plasma circadian rhythms were found to be totally abolished in the three patients with the longest operative times (mean = 3.8 hr) and significantly displaced in time in the remaining four patients. These prolonged alterations in plasma endogenous opioid peptide levels following surgery have not been previously reported, and should be considered in the management of the postsurgical patient. |
| doi_str_mv | 10.1016/0022-4804(85)90028-9 |
| format | Article |
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P < 0.005). Surgical procedures caused significant phase shifting in the grouped mean circadian rhythm of plasma β-endorphin (mean = 2.4 hr). When the data was analyzed individually, plasma circadian rhythms were found to be totally abolished in the three patients with the longest operative times (mean = 3.8 hr) and significantly displaced in time in the remaining four patients. These prolonged alterations in plasma endogenous opioid peptide levels following surgery have not been previously reported, and should be considered in the management of the postsurgical patient.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/0022-4804(85)90028-9</identifier><identifier>PMID: 3157023</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; beta-Endorphin ; Biological and medical sciences ; Circadian Rhythm ; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery ; Endorphins - blood ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Postoperative Period ; Radioimmunoassay ; Regression Analysis ; Surgical Procedures, Operative</subject><ispartof>The Journal of surgical research, 1985-01, Vol.38 (3), p.210-215</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-ef85a4830f6efb72c539854902aeae5e4327548f714b15a5ee7f82743277d3323</citedby><cites>FETCH-LOGICAL-c415t-ef85a4830f6efb72c539854902aeae5e4327548f714b15a5ee7f82743277d3323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022480485900289$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9100774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3157023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McIntosh, Tracy K.</creatorcontrib><creatorcontrib>Bush, Harry L.</creatorcontrib><creatorcontrib>Palter, Marc</creatorcontrib><creatorcontrib>Hay, James R.</creatorcontrib><creatorcontrib>Aun, Frederico</creatorcontrib><creatorcontrib>Yeston, Neil S.</creatorcontrib><creatorcontrib>Egdahl, Richard H.</creatorcontrib><title>Prolonged disruption of plasma β-endorphin dynamics following surgery</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>The purpose of the present study was to examine the effects of surgery on plasma β-endorphin dynamics. Plasma β-endorphin levels were measured by liquid chromatography/radioimmunoassay in seven patients undergoing elective surgery. Blood samples were obtained every 4 hr for two 24-hr periods: one beginning 48 hr before surgery and the other beginning 48 hr after surgery. Computer analysis of β-endorphin levels as a function of clock time demonstrated a true circadian rhythm preoperatively with a mean of 28.0 ± 5.9 pg/ml. In the postoperative period mean β-endorphin levels were significantly elevated (85.6 ± 20.7 pg/ml,
P < 0.005). Surgical procedures caused significant phase shifting in the grouped mean circadian rhythm of plasma β-endorphin (mean = 2.4 hr). When the data was analyzed individually, plasma circadian rhythms were found to be totally abolished in the three patients with the longest operative times (mean = 3.8 hr) and significantly displaced in time in the remaining four patients. These prolonged alterations in plasma endogenous opioid peptide levels following surgery have not been previously reported, and should be considered in the management of the postsurgical patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>beta-Endorphin</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</subject><subject>Endorphins - blood</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Period</subject><subject>Radioimmunoassay</subject><subject>Regression Analysis</subject><subject>Surgical Procedures, Operative</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9qGzEQh0VJSBw3b9DAHkJID5vq70p7CQRTNwFDemjOQtaOXIVdaSN5U_xafZA-U9f14mNPw8zvm2H4EPpE8B3BpPqCMaUlV5jfKvG5HjtV1h_QjOBalKqS7ATNjsg5usj5FY99LdkZOmNESEzZDC2_p9jGsIGmaHxOQ7_1MRTRFX1rcmeKP79LCE1M_U8fimYXTOdtLlxs2_jLh02Rh7SBtPuITp1pM1xOdY5ell9_LB7L1fO3p8XDqrSciG0JTgnDFcOuAreW1ApWK8FrTA0YEMAZlYIrJwlfE2EEgHSKyv1YNoxRNkc3h7t9im8D5K3ufLbQtiZAHLKWFeZUSDmC_ADaFHNO4HSffGfSThOs9_r03o3eu9FK6H_6dD2uXU33h3UHzXFp8jXm11NusjWtSyZYn49YTTCW47tzdH_AYHTx7iHpbD0EC41PYLe6if7_f_wFEF2LoQ</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>McIntosh, Tracy K.</creator><creator>Bush, Harry L.</creator><creator>Palter, Marc</creator><creator>Hay, James R.</creator><creator>Aun, Frederico</creator><creator>Yeston, Neil S.</creator><creator>Egdahl, Richard H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Prolonged disruption of plasma β-endorphin dynamics following surgery</title><author>McIntosh, Tracy K. ; Bush, Harry L. ; Palter, Marc ; Hay, James R. ; Aun, Frederico ; Yeston, Neil S. ; Egdahl, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-ef85a4830f6efb72c539854902aeae5e4327548f714b15a5ee7f82743277d3323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>beta-Endorphin</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</topic><topic>Endorphins - blood</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Period</topic><topic>Radioimmunoassay</topic><topic>Regression Analysis</topic><topic>Surgical Procedures, Operative</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McIntosh, Tracy K.</creatorcontrib><creatorcontrib>Bush, Harry L.</creatorcontrib><creatorcontrib>Palter, Marc</creatorcontrib><creatorcontrib>Hay, James R.</creatorcontrib><creatorcontrib>Aun, Frederico</creatorcontrib><creatorcontrib>Yeston, Neil S.</creatorcontrib><creatorcontrib>Egdahl, Richard H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McIntosh, Tracy K.</au><au>Bush, Harry L.</au><au>Palter, Marc</au><au>Hay, James R.</au><au>Aun, Frederico</au><au>Yeston, Neil S.</au><au>Egdahl, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged disruption of plasma β-endorphin dynamics following surgery</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>38</volume><issue>3</issue><spage>210</spage><epage>215</epage><pages>210-215</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>The purpose of the present study was to examine the effects of surgery on plasma β-endorphin dynamics. Plasma β-endorphin levels were measured by liquid chromatography/radioimmunoassay in seven patients undergoing elective surgery. Blood samples were obtained every 4 hr for two 24-hr periods: one beginning 48 hr before surgery and the other beginning 48 hr after surgery. Computer analysis of β-endorphin levels as a function of clock time demonstrated a true circadian rhythm preoperatively with a mean of 28.0 ± 5.9 pg/ml. In the postoperative period mean β-endorphin levels were significantly elevated (85.6 ± 20.7 pg/ml,
P < 0.005). Surgical procedures caused significant phase shifting in the grouped mean circadian rhythm of plasma β-endorphin (mean = 2.4 hr). When the data was analyzed individually, plasma circadian rhythms were found to be totally abolished in the three patients with the longest operative times (mean = 3.8 hr) and significantly displaced in time in the remaining four patients. These prolonged alterations in plasma endogenous opioid peptide levels following surgery have not been previously reported, and should be considered in the management of the postsurgical patient.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3157023</pmid><doi>10.1016/0022-4804(85)90028-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy beta-Endorphin Biological and medical sciences Circadian Rhythm Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery Endorphins - blood Humans Intensive care medicine Male Medical sciences Middle Aged Postoperative Period Radioimmunoassay Regression Analysis Surgical Procedures, Operative |
| title | Prolonged disruption of plasma β-endorphin dynamics following surgery |
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