Differential expression of P-glycoprotein genes in primary rat hepatocyte culture

The multidrug resistance (MDR)–associated protein, P‐glycoprotein (Pgp), is expressed on the bile canalicular surface of hepatocytes, where it is thought to function in the detoxification of xenobiotics or in the transport of specific metabolites. Several studies have shown that Pgp expression in ra...

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Veröffentlicht in:	Journal of cellular physiology 1993-11, Vol.157 (2), p.392-402
Hauptverfasser:	Lee, Chow Hwee, Bradley, Grace, Zhang, Jian-Ting, Ling, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - chemistry Actin Cytoskeleton - drug effects Actin Cytoskeleton - metabolism Actins - analysis Actins - genetics Actins - metabolism Analytical, structural and metabolic biochemistry Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 Base Sequence Biological and medical sciences Blotting, Northern Blotting, Southern Blotting, Western Carrier Proteins - analysis Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Connexins - analysis Connexins - genetics Connexins - metabolism Cytoskeletal Proteins - analysis Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Fundamental and applied biological sciences. Psychology Gap Junction beta-1 Protein Gene Expression - genetics Genes - genetics Glycoproteins Liver - chemistry Liver - cytology Liver - metabolism Male Membrane Glycoproteins - analysis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microtubules - chemistry Microtubules - drug effects Microtubules - metabolism Molecular Sequence Data Proteins Rats Rats, Inbred F344 RNA, Messenger - analysis RNA, Messenger - genetics RNA, Messenger - metabolism Tubulin - analysis Tubulin - genetics Tubulin - metabolism
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