Synthetic insulin-like growth factor II

Human insulin-like growth factor II with 67 amino acid residues and three disulfide bridges has been synthesized by the solid-phase method. Homogeneity of the synthetic product is ascertained by chromatofocusing, high performance liquid chromatography and amino acid analysis. In both radioimmunoassa...

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Veröffentlicht in:	Biochemical and biophysical research communications 1985-03, Vol.127 (2), p.420-424
Hauptverfasser:	Choh Hao Li, Yamashiro, Donald, Glenn Hammonds, R., Westphal, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Applied sciences Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Exact sciences and technology Humans IGF-II Insulin - chemical synthesis Isoelectric Focusing Other techniques and industries Peptides - chemical synthesis Radioimmunoassay Radioligand Assay Somatomedins - chemical synthesis synthesis
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Beschreibung
Zusammenfassung:	Human insulin-like growth factor II with 67 amino acid residues and three disulfide bridges has been synthesized by the solid-phase method. Homogeneity of the synthetic product is ascertained by chromatofocusing, high performance liquid chromatography and amino acid analysis. In both radioimmunoassay and radioreceptor assay, the synthetic product is indistinquishable from the natural hormone.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(85)80177-7