Experimental amyotrophic lateral sclerosis in the Guinea-Pig
In guinea-pigs a diet which was deficient in ascorbic acid provoked neurogenic atrophy of the muscles, degeneration of the anterior horn motor cells and demyelination of the pyramidal tract. Muscles showed a decrease of cytochrome and cytochrome c oxidase. Subcutaneous haemorrhages were also found,...
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| Veröffentlicht in: | Journal of the neurological sciences 1985-02, Vol.67 (2), p.133-142 |
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| container_title | Journal of the neurological sciences |
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| creator | den Hartog Jager, W.A. |
| description | In guinea-pigs a diet which was deficient in ascorbic acid provoked neurogenic atrophy of the muscles, degeneration of the anterior horn motor cells and demyelination of the pyramidal tract. Muscles showed a decrease of cytochrome and cytochrome
c oxidase. Subcutaneous haemorrhages were also found, particularly around the knee joints. The haemorrhages and the histopathology of the muscles and spinal cord were prevented by a high dosage of ascorbic acid. In animals with an ascorbic acid deficiency, histopathology of muscles and spinal cord were also prevented by
l-cysteine,
l-methionine and
l-hydroxyproline. Subcutaneous haemorrhages were not prevented by these supplements. |
| doi_str_mv | 10.1016/0022-510X(85)90110-8 |
| format | Article |
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c oxidase. Subcutaneous haemorrhages were also found, particularly around the knee joints. The haemorrhages and the histopathology of the muscles and spinal cord were prevented by a high dosage of ascorbic acid. In animals with an ascorbic acid deficiency, histopathology of muscles and spinal cord were also prevented by
l-cysteine,
l-methionine and
l-hydroxyproline. Subcutaneous haemorrhages were not prevented by these supplements.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(85)90110-8</identifier><identifier>PMID: 3981216</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Amyotrophic Lateral Sclerosis - pathology ; Animals ; Anterior Horn Cells - pathology ; Ascorbic Acid Deficiency ; Biological and medical sciences ; Cysteine ; Cytochrome c ; Disease Models, Animal ; Experimental amyotrophic lateral sclerosis ; Guinea Pigs ; Hydroxyproline ; Male ; Medical sciences ; Methionine ; Motor Neurons - pathology ; Muscles - pathology ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Pyramidal Tracts - pathology</subject><ispartof>Journal of the neurological sciences, 1985-02, Vol.67 (2), p.133-142</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c7e84cc4d979200a1f25809b4e906987883948e19c718a82a2852bd7402ea2383</citedby><cites>FETCH-LOGICAL-c386t-c7e84cc4d979200a1f25809b4e906987883948e19c718a82a2852bd7402ea2383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(85)90110-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9160954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3981216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>den Hartog Jager, W.A.</creatorcontrib><title>Experimental amyotrophic lateral sclerosis in the Guinea-Pig</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>In guinea-pigs a diet which was deficient in ascorbic acid provoked neurogenic atrophy of the muscles, degeneration of the anterior horn motor cells and demyelination of the pyramidal tract. Muscles showed a decrease of cytochrome and cytochrome
c oxidase. Subcutaneous haemorrhages were also found, particularly around the knee joints. The haemorrhages and the histopathology of the muscles and spinal cord were prevented by a high dosage of ascorbic acid. In animals with an ascorbic acid deficiency, histopathology of muscles and spinal cord were also prevented by
l-cysteine,
l-methionine and
l-hydroxyproline. Subcutaneous haemorrhages were not prevented by these supplements.</description><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Animals</subject><subject>Anterior Horn Cells - pathology</subject><subject>Ascorbic Acid Deficiency</subject><subject>Biological and medical sciences</subject><subject>Cysteine</subject><subject>Cytochrome c</subject><subject>Disease Models, Animal</subject><subject>Experimental amyotrophic lateral sclerosis</subject><subject>Guinea Pigs</subject><subject>Hydroxyproline</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methionine</subject><subject>Motor Neurons - pathology</subject><subject>Muscles - pathology</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Pyramidal Tracts - pathology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRaq3-A4UcRPQQnd18zYIIUmoVCnpQ8LZsN1O7kiZ1NxH7701s6NHTwMyzL-8-jJ1yuObA0xsAIcKEw_slJlcSOIcQ99iQY4Zhghjts-EOOWRH3n8CQIooB2wQSeSCp0N2O_lZk7MrKmtdBHq1qWpXrZfWBIWuybU7bwpylbc-sGVQLymYNrYkHb7Yj2N2sNCFp5N-jtjbw-R1_BjOnqdP4_tZaCJM69BkhLExcS4zKQA0X4gEQc5jkpDKti5GMkbi0mQcNQotMBHzPItBkBYRRiN2sc1du-qrIV-rlfWGikKXVDVeZSlEUkZZC8Zb0LSNvaOFWrd_026jOKhOmuqMqM6IwkT9SVNd_lmf38xXlO8e9Zba-3l_197oYuF0aazfYZKnIJO4xe62GLUuvi055Y2l0lBuHZla5ZX9v8cv4vaGng</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>den Hartog Jager, W.A.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Experimental amyotrophic lateral sclerosis in the Guinea-Pig</title><author>den Hartog Jager, W.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c7e84cc4d979200a1f25809b4e906987883948e19c718a82a2852bd7402ea2383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Animals</topic><topic>Anterior Horn Cells - pathology</topic><topic>Ascorbic Acid Deficiency</topic><topic>Biological and medical sciences</topic><topic>Cysteine</topic><topic>Cytochrome c</topic><topic>Disease Models, Animal</topic><topic>Experimental amyotrophic lateral sclerosis</topic><topic>Guinea Pigs</topic><topic>Hydroxyproline</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methionine</topic><topic>Motor Neurons - pathology</topic><topic>Muscles - pathology</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Pyramidal Tracts - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>den Hartog Jager, W.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>den Hartog Jager, W.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental amyotrophic lateral sclerosis in the Guinea-Pig</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1985-02</date><risdate>1985</risdate><volume>67</volume><issue>2</issue><spage>133</spage><epage>142</epage><pages>133-142</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>In guinea-pigs a diet which was deficient in ascorbic acid provoked neurogenic atrophy of the muscles, degeneration of the anterior horn motor cells and demyelination of the pyramidal tract. Muscles showed a decrease of cytochrome and cytochrome
c oxidase. Subcutaneous haemorrhages were also found, particularly around the knee joints. The haemorrhages and the histopathology of the muscles and spinal cord were prevented by a high dosage of ascorbic acid. In animals with an ascorbic acid deficiency, histopathology of muscles and spinal cord were also prevented by
l-cysteine,
l-methionine and
l-hydroxyproline. Subcutaneous haemorrhages were not prevented by these supplements.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>3981216</pmid><doi>10.1016/0022-510X(85)90110-8</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1985-02, Vol.67 (2), p.133-142 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76039937 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amyotrophic Lateral Sclerosis - pathology Animals Anterior Horn Cells - pathology Ascorbic Acid Deficiency Biological and medical sciences Cysteine Cytochrome c Disease Models, Animal Experimental amyotrophic lateral sclerosis Guinea Pigs Hydroxyproline Male Medical sciences Methionine Motor Neurons - pathology Muscles - pathology Nervous system involvement in other diseases. Miscellaneous Neurology Pyramidal Tracts - pathology |
| title | Experimental amyotrophic lateral sclerosis in the Guinea-Pig |
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