Liposarcoma in patients younger than or equal to 22 years of age
Background. There have been few reported series of liposarcomas in patients younger than or equal to 22 years of age. Methods. A retrospective analysis of all patients presenting with liposarcoma between 1949–1990 at Memorial Sloan‐Kettering Cancer Center with age at diagnosis younger than or equal...
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| Veröffentlicht in: | Cancer 1993-11, Vol.72 (10), p.3114-3119 |
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| container_title | Cancer |
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| creator | La Quaglia, Michael P. Spiro, Scott A. Ghavimi, Fereshteh Hajdu, Steven I. Meyers, Paul Exelby, Philip R. |
| description | Background. There have been few reported series of liposarcomas in patients younger than or equal to 22 years of age.
Methods. A retrospective analysis of all patients presenting with liposarcoma between 1949–1990 at Memorial Sloan‐Kettering Cancer Center with age at diagnosis younger than or equal to 22 years was performed. Variables evaluated for their predictive effect on survival included anatomic location of the primary, size, and completeness of surgical resection.
Results. Eighteen patients were identified. Only 1 patient (6%) presented with a high‐grade lesion, and in 13 patients (72%), the myxoid subtype was observed. All but one patient undergoing complete resection remain disease‐free 1.3–29.1 years after treatment, while all patients with gross residual tumor have died from disease. Two of three patients with microscopic residual at resection are disease‐free 2 and 11.8 years after diagnosis with the addition of external beam radiation therapy.
Conclusions. The authors conclude that complete surgical resection is crucial for survival in young patients with liposarcoma and that external beam radiation therapy may be effective against microscopic residual. |
| doi_str_mv | 10.1002/1097-0142(19931115)72:10<3114::AID-CNCR2820721037>3.0.CO;2-I |
| format | Article |
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Methods. A retrospective analysis of all patients presenting with liposarcoma between 1949–1990 at Memorial Sloan‐Kettering Cancer Center with age at diagnosis younger than or equal to 22 years was performed. Variables evaluated for their predictive effect on survival included anatomic location of the primary, size, and completeness of surgical resection.
Results. Eighteen patients were identified. Only 1 patient (6%) presented with a high‐grade lesion, and in 13 patients (72%), the myxoid subtype was observed. All but one patient undergoing complete resection remain disease‐free 1.3–29.1 years after treatment, while all patients with gross residual tumor have died from disease. Two of three patients with microscopic residual at resection are disease‐free 2 and 11.8 years after diagnosis with the addition of external beam radiation therapy.
Conclusions. The authors conclude that complete surgical resection is crucial for survival in young patients with liposarcoma and that external beam radiation therapy may be effective against microscopic residual.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19931115)72:10<3114::AID-CNCR2820721037>3.0.CO;2-I</identifier><identifier>PMID: 8221578</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Combined Modality Therapy ; Dermatology ; Female ; Humans ; Infant ; liposarcoma ; Liposarcoma - mortality ; Liposarcoma - pathology ; Liposarcoma - surgery ; Male ; Medical sciences ; pediatrics ; Prognosis ; Retrospective Studies ; Soft Tissue Neoplasms - mortality ; Soft Tissue Neoplasms - pathology ; Soft Tissue Neoplasms - surgery ; Survival Rate ; Thigh ; treatment ; Tumors of the skin and soft tissue. Premalignant lesions ; young</subject><ispartof>Cancer, 1993-11, Vol.72 (10), p.3114-3119</ispartof><rights>Copyright © 1993 American Cancer Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5017-82d9a73e8cc159a1fa7b08add460dfca075c03c13cbbdebc5685f543b6802ff03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3846163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8221578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La Quaglia, Michael P.</creatorcontrib><creatorcontrib>Spiro, Scott A.</creatorcontrib><creatorcontrib>Ghavimi, Fereshteh</creatorcontrib><creatorcontrib>Hajdu, Steven I.</creatorcontrib><creatorcontrib>Meyers, Paul</creatorcontrib><creatorcontrib>Exelby, Philip R.</creatorcontrib><title>Liposarcoma in patients younger than or equal to 22 years of age</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background. There have been few reported series of liposarcomas in patients younger than or equal to 22 years of age.
Methods. A retrospective analysis of all patients presenting with liposarcoma between 1949–1990 at Memorial Sloan‐Kettering Cancer Center with age at diagnosis younger than or equal to 22 years was performed. Variables evaluated for their predictive effect on survival included anatomic location of the primary, size, and completeness of surgical resection.
Results. Eighteen patients were identified. Only 1 patient (6%) presented with a high‐grade lesion, and in 13 patients (72%), the myxoid subtype was observed. All but one patient undergoing complete resection remain disease‐free 1.3–29.1 years after treatment, while all patients with gross residual tumor have died from disease. Two of three patients with microscopic residual at resection are disease‐free 2 and 11.8 years after diagnosis with the addition of external beam radiation therapy.
Conclusions. The authors conclude that complete surgical resection is crucial for survival in young patients with liposarcoma and that external beam radiation therapy may be effective against microscopic residual.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Combined Modality Therapy</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>liposarcoma</subject><subject>Liposarcoma - mortality</subject><subject>Liposarcoma - pathology</subject><subject>Liposarcoma - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>pediatrics</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Soft Tissue Neoplasms - mortality</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - surgery</subject><subject>Survival Rate</subject><subject>Thigh</subject><subject>treatment</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>young</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFGL1DAUhYO4rLOrP0HIg8j60PEmaZt0lMWl6-rA4IAo-CBc0jQZK51mNmlZ5t_bMuOAPgg-5eaecw-Hj5BbBnMGwF8zKGQCLOVXrCgEYyx7JfmCwdtxTheLm-VtUn4qP3PFQXIGQl6LOczL9RueLB-R2en8MZkBgEqyVHx7Qi5i_Dl-Jc_EOTlXnLNMqhl5t2p2Pupg_FbTpqM73Te26yPd-6Hb2ED7H7qjPlB7P-iW9p5yTvdWh0i9o3pjn5Izp9tonx3fS_L17v2X8mOyWn9YljerxGTAZKJ4XWgprDKGZYVmTssKlK7rNIfaGQ0yMyAME6aqaluZLFeZG5tXuQLuHIhL8vKQuwv-frCxx20TjW1b3Vk_RJQ5iKKAdDR-PxhN8DEG63AXmq0Oe2SAE2CcCOFECH8DRjltcQKMOALGPwGjQMByjRyXY_zzY4-h2tr6FH4kOuovjrqORrcu6M408WQTKs1ZLkbb5mB7aFq7_8-K_2z4lyJ-AYqqpEM</recordid><startdate>19931115</startdate><enddate>19931115</enddate><creator>La Quaglia, Michael P.</creator><creator>Spiro, Scott A.</creator><creator>Ghavimi, Fereshteh</creator><creator>Hajdu, Steven I.</creator><creator>Meyers, Paul</creator><creator>Exelby, Philip R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931115</creationdate><title>Liposarcoma in patients younger than or equal to 22 years of age</title><author>La Quaglia, Michael P. ; Spiro, Scott A. ; Ghavimi, Fereshteh ; Hajdu, Steven I. ; Meyers, Paul ; Exelby, Philip R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5017-82d9a73e8cc159a1fa7b08add460dfca075c03c13cbbdebc5685f543b6802ff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Combined Modality Therapy</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>liposarcoma</topic><topic>Liposarcoma - mortality</topic><topic>Liposarcoma - pathology</topic><topic>Liposarcoma - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>pediatrics</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Soft Tissue Neoplasms - mortality</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Soft Tissue Neoplasms - surgery</topic><topic>Survival Rate</topic><topic>Thigh</topic><topic>treatment</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>young</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>La Quaglia, Michael P.</creatorcontrib><creatorcontrib>Spiro, Scott A.</creatorcontrib><creatorcontrib>Ghavimi, Fereshteh</creatorcontrib><creatorcontrib>Hajdu, Steven I.</creatorcontrib><creatorcontrib>Meyers, Paul</creatorcontrib><creatorcontrib>Exelby, Philip R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>La Quaglia, Michael P.</au><au>Spiro, Scott A.</au><au>Ghavimi, Fereshteh</au><au>Hajdu, Steven I.</au><au>Meyers, Paul</au><au>Exelby, Philip R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liposarcoma in patients younger than or equal to 22 years of age</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1993-11-15</date><risdate>1993</risdate><volume>72</volume><issue>10</issue><spage>3114</spage><epage>3119</epage><pages>3114-3119</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Background. There have been few reported series of liposarcomas in patients younger than or equal to 22 years of age.
Methods. A retrospective analysis of all patients presenting with liposarcoma between 1949–1990 at Memorial Sloan‐Kettering Cancer Center with age at diagnosis younger than or equal to 22 years was performed. Variables evaluated for their predictive effect on survival included anatomic location of the primary, size, and completeness of surgical resection.
Results. Eighteen patients were identified. Only 1 patient (6%) presented with a high‐grade lesion, and in 13 patients (72%), the myxoid subtype was observed. All but one patient undergoing complete resection remain disease‐free 1.3–29.1 years after treatment, while all patients with gross residual tumor have died from disease. Two of three patients with microscopic residual at resection are disease‐free 2 and 11.8 years after diagnosis with the addition of external beam radiation therapy.
Conclusions. The authors conclude that complete surgical resection is crucial for survival in young patients with liposarcoma and that external beam radiation therapy may be effective against microscopic residual.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8221578</pmid><doi>10.1002/1097-0142(19931115)72:10<3114::AID-CNCR2820721037>3.0.CO;2-I</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Child Combined Modality Therapy Dermatology Female Humans Infant liposarcoma Liposarcoma - mortality Liposarcoma - pathology Liposarcoma - surgery Male Medical sciences pediatrics Prognosis Retrospective Studies Soft Tissue Neoplasms - mortality Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - surgery Survival Rate Thigh treatment Tumors of the skin and soft tissue. Premalignant lesions young |
| title | Liposarcoma in patients younger than or equal to 22 years of age |
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