Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells

Using an in situ kinase assay we have identified kinases that are elevated in some multidrug resistant cells. Kinases were detected by measurement of 32P incorporation in proteins that were renatured after being subjected to SDS‐polyacrylamide gel electrophoresis and transferred to polyvinylidene di...

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Veröffentlicht in:	Journal of cellular biochemistry 1993-08, Vol.52 (4), p.384-395
Hauptverfasser:	Sampson, Kathleen E., McCroskey, Mark C., Abraham, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	170 kDa Alkaloids - pharmacology Analytical, structural and metabolic biochemistry Animals Antineoplastic Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 Biological and medical sciences Breast Neoplasms - pathology Calcium - pharmacology Carbazoles - pharmacology Carrier Proteins - analysis Clone Cells - drug effects Clone Cells - enzymology Cyclic AMP - pharmacology Drug Resistance EGF-receptor Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Indole Alkaloids Indoles - pharmacology KB Cells - drug effects KB Cells - enzymology kinase Melanoma, Experimental - pathology membrane Membrane Glycoproteins - analysis Mice multidrug resistance Neoplasm Proteins - isolation & purification Neoplasm Proteins - metabolism P-glycoprotein Phosphatidylserines - pharmacology Phosphorylation Phosphothreonine - analysis Phosphotyrosine Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - isolation & purification Protein-Serine-Threonine Kinases - metabolism Pyrroles - pharmacology Staurosporine Transfection Transferases Tumor Cells, Cultured Tyrosine - analogs & derivatives Tyrosine - analysis
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