Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide
The use of reversed-phase liquid chromotography and radiochemical detection with carbon-11 (t 1 2 = 20.4 min) as a tracer allowed the study of the preparation of [ 11C]urea from [ 11C]cyanide at no carrier-added concentrations. [ 11C]cyanate was readily prepared by permanganate oxidation of [ 11C]cy...
Gespeichert in:
| Veröffentlicht in: | The International journal of applied radiation and isotopes 1985-02, Vol.36 (2), p.141-144 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 144 |
|---|---|
| container_issue | 2 |
| container_start_page | 141 |
| container_title | The International journal of applied radiation and isotopes |
| container_volume | 36 |
| creator | Boothe, Thomas E. Emran, Ali M. Finn, Ronald D. Vora, Manhar M. Kothari, Paresh J. |
| description | The use of reversed-phase liquid chromotography and radiochemical detection with carbon-11
(t
1
2
= 20.4
min)
as a tracer allowed the study of the preparation of [
11C]urea from [
11C]cyanide at no carrier-added concentrations. [
11C]cyanate was readily prepared by permanganate oxidation of [
11C]cyanide at 75°C. The conversion of NH
4O
11CN (≈0.03 mM) to [
11C]urea in the presence of excess ammonium ions (0.28 M) was found to best fit pseudo first order reaction kinetics with a rate constant of 0.065 ± 0.008 min
−1 at 75°C. Heating at higher temperatures (180–200°C) revealed that the conversion of NH
4O
11CN to [
11C]urea occured in high yield in less than 3 min. The hydrolysis of [
11C]cyanate to [
11C]carbonate, a possible side reaction, was found to proceed at a rate of 0.010 ± 0.001 min
−1 at 113°C. |
| doi_str_mv | 10.1016/0020-708X(85)90229-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76039499</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0020708X85902297</els_id><sourcerecordid>76039499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2330-e8b8cc410d45f904afcab94bf60aba16aed8055d1c58b5b625fa02032217d7bd3</originalsourceid><addsrcrecordid>eNp9kFFr1TAUx_Mw2ebmN9ggDyL6UD1pmzZ5EcbFqTAYiANBJJwmJxq5t505rXC__VpvuY8-HZL_7_xJfkJcKXirQDXvAEooWjDfXhv9xkJZ2qI9EefH6zPxnPk3LEFjTsVpZQ2oEs7FlwcmOUSp1EYiS5RjRk9ZxiFLHqewT_1POf4iyft-Hpx4ob8v_I8pE8qYh9169nvsU6BL8SzilunFOi_Ew-2Hr5tPxd39x8-bm7vCl1UFBZnOeF8rCLWOFmqMHjtbd7EB7FA1SMGA1kF5bTrdNaWOOH-nKkvVhrYL1YV4deh9zMOfiXh0u8SetlvsaZjYtQ1UtrZ2BusD6PPAnCm6x5x2mPdOgVv0ucWTWzw5o90_fa6d167X_qnbUTgure7m_OWaI3vcxoy9T3zELFRK6aXm_QGj2cXfRNmxT9R7CimTH10Y0v_f8QSe2ouQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76039499</pqid></control><display><type>article</type><title>Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Boothe, Thomas E. ; Emran, Ali M. ; Finn, Ronald D. ; Vora, Manhar M. ; Kothari, Paresh J.</creator><creatorcontrib>Boothe, Thomas E. ; Emran, Ali M. ; Finn, Ronald D. ; Vora, Manhar M. ; Kothari, Paresh J.</creatorcontrib><description>The use of reversed-phase liquid chromotography and radiochemical detection with carbon-11
(t
1
2
= 20.4
min)
as a tracer allowed the study of the preparation of [
11C]urea from [
11C]cyanide at no carrier-added concentrations. [
11C]cyanate was readily prepared by permanganate oxidation of [
11C]cyanide at 75°C. The conversion of NH
4O
11CN (≈0.03 mM) to [
11C]urea in the presence of excess ammonium ions (0.28 M) was found to best fit pseudo first order reaction kinetics with a rate constant of 0.065 ± 0.008 min
−1 at 75°C. Heating at higher temperatures (180–200°C) revealed that the conversion of NH
4O
11CN to [
11C]urea occured in high yield in less than 3 min. The hydrolysis of [
11C]cyanate to [
11C]carbonate, a possible side reaction, was found to proceed at a rate of 0.010 ± 0.001 min
−1 at 113°C.</description><identifier>ISSN: 0020-708X</identifier><identifier>DOI: 10.1016/0020-708X(85)90229-7</identifier><identifier>PMID: 3980120</identifier><identifier>CODEN: ARISEF</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Aliphatic compounds ; Carbon Radioisotopes ; Chemistry ; Chromatography, High Pressure Liquid ; Cyanides - metabolism ; Exact sciences and technology ; Organic chemistry ; Preparations and properties ; Urea - chemical synthesis</subject><ispartof>The International journal of applied radiation and isotopes, 1985-02, Vol.36 (2), p.141-144</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2330-e8b8cc410d45f904afcab94bf60aba16aed8055d1c58b5b625fa02032217d7bd3</citedby><cites>FETCH-LOGICAL-c2330-e8b8cc410d45f904afcab94bf60aba16aed8055d1c58b5b625fa02032217d7bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9031157$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3980120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boothe, Thomas E.</creatorcontrib><creatorcontrib>Emran, Ali M.</creatorcontrib><creatorcontrib>Finn, Ronald D.</creatorcontrib><creatorcontrib>Vora, Manhar M.</creatorcontrib><creatorcontrib>Kothari, Paresh J.</creatorcontrib><title>Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide</title><title>The International journal of applied radiation and isotopes</title><addtitle>Int J Appl Radiat Isot</addtitle><description>The use of reversed-phase liquid chromotography and radiochemical detection with carbon-11
(t
1
2
= 20.4
min)
as a tracer allowed the study of the preparation of [
11C]urea from [
11C]cyanide at no carrier-added concentrations. [
11C]cyanate was readily prepared by permanganate oxidation of [
11C]cyanide at 75°C. The conversion of NH
4O
11CN (≈0.03 mM) to [
11C]urea in the presence of excess ammonium ions (0.28 M) was found to best fit pseudo first order reaction kinetics with a rate constant of 0.065 ± 0.008 min
−1 at 75°C. Heating at higher temperatures (180–200°C) revealed that the conversion of NH
4O
11CN to [
11C]urea occured in high yield in less than 3 min. The hydrolysis of [
11C]cyanate to [
11C]carbonate, a possible side reaction, was found to proceed at a rate of 0.010 ± 0.001 min
−1 at 113°C.</description><subject>Aliphatic compounds</subject><subject>Carbon Radioisotopes</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyanides - metabolism</subject><subject>Exact sciences and technology</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Urea - chemical synthesis</subject><issn>0020-708X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFr1TAUx_Mw2ebmN9ggDyL6UD1pmzZ5EcbFqTAYiANBJJwmJxq5t505rXC__VpvuY8-HZL_7_xJfkJcKXirQDXvAEooWjDfXhv9xkJZ2qI9EefH6zPxnPk3LEFjTsVpZQ2oEs7FlwcmOUSp1EYiS5RjRk9ZxiFLHqewT_1POf4iyft-Hpx4ob8v_I8pE8qYh9169nvsU6BL8SzilunFOi_Ew-2Hr5tPxd39x8-bm7vCl1UFBZnOeF8rCLWOFmqMHjtbd7EB7FA1SMGA1kF5bTrdNaWOOH-nKkvVhrYL1YV4deh9zMOfiXh0u8SetlvsaZjYtQ1UtrZ2BusD6PPAnCm6x5x2mPdOgVv0ucWTWzw5o90_fa6d167X_qnbUTgure7m_OWaI3vcxoy9T3zELFRK6aXm_QGj2cXfRNmxT9R7CimTH10Y0v_f8QSe2ouQ</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Boothe, Thomas E.</creator><creator>Emran, Ali M.</creator><creator>Finn, Ronald D.</creator><creator>Vora, Manhar M.</creator><creator>Kothari, Paresh J.</creator><general>Elsevier B.V</general><general>Pergamon Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide</title><author>Boothe, Thomas E. ; Emran, Ali M. ; Finn, Ronald D. ; Vora, Manhar M. ; Kothari, Paresh J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2330-e8b8cc410d45f904afcab94bf60aba16aed8055d1c58b5b625fa02032217d7bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aliphatic compounds</topic><topic>Carbon Radioisotopes</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyanides - metabolism</topic><topic>Exact sciences and technology</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>Urea - chemical synthesis</topic><toplevel>online_resources</toplevel><creatorcontrib>Boothe, Thomas E.</creatorcontrib><creatorcontrib>Emran, Ali M.</creatorcontrib><creatorcontrib>Finn, Ronald D.</creatorcontrib><creatorcontrib>Vora, Manhar M.</creatorcontrib><creatorcontrib>Kothari, Paresh J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boothe, Thomas E.</au><au>Emran, Ali M.</au><au>Finn, Ronald D.</au><au>Vora, Manhar M.</au><au>Kothari, Paresh J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide</atitle><jtitle>The International journal of applied radiation and isotopes</jtitle><addtitle>Int J Appl Radiat Isot</addtitle><date>1985-02</date><risdate>1985</risdate><volume>36</volume><issue>2</issue><spage>141</spage><epage>144</epage><pages>141-144</pages><issn>0020-708X</issn><coden>ARISEF</coden><abstract>The use of reversed-phase liquid chromotography and radiochemical detection with carbon-11
(t
1
2
= 20.4
min)
as a tracer allowed the study of the preparation of [
11C]urea from [
11C]cyanide at no carrier-added concentrations. [
11C]cyanate was readily prepared by permanganate oxidation of [
11C]cyanide at 75°C. The conversion of NH
4O
11CN (≈0.03 mM) to [
11C]urea in the presence of excess ammonium ions (0.28 M) was found to best fit pseudo first order reaction kinetics with a rate constant of 0.065 ± 0.008 min
−1 at 75°C. Heating at higher temperatures (180–200°C) revealed that the conversion of NH
4O
11CN to [
11C]urea occured in high yield in less than 3 min. The hydrolysis of [
11C]cyanate to [
11C]carbonate, a possible side reaction, was found to proceed at a rate of 0.010 ± 0.001 min
−1 at 113°C.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3980120</pmid><doi>10.1016/0020-708X(85)90229-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-708X |
| ispartof | The International journal of applied radiation and isotopes, 1985-02, Vol.36 (2), p.141-144 |
| issn | 0020-708X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76039499 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aliphatic compounds Carbon Radioisotopes Chemistry Chromatography, High Pressure Liquid Cyanides - metabolism Exact sciences and technology Organic chemistry Preparations and properties Urea - chemical synthesis |
| title | Use of 11C as a tracer for studying the synthesis of [ 11C]urea from [ 11C]cyanide |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T16%3A15%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%2011C%20as%20a%20tracer%20for%20studying%20the%20synthesis%20of%20%5B%2011C%5Durea%20from%20%5B%2011C%5Dcyanide&rft.jtitle=The%20International%20journal%20of%20applied%20radiation%20and%20isotopes&rft.au=Boothe,%20Thomas%20E.&rft.date=1985-02&rft.volume=36&rft.issue=2&rft.spage=141&rft.epage=144&rft.pages=141-144&rft.issn=0020-708X&rft.coden=ARISEF&rft_id=info:doi/10.1016/0020-708X(85)90229-7&rft_dat=%3Cproquest_cross%3E76039499%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76039499&rft_id=info:pmid/3980120&rft_els_id=0020708X85902297&rfr_iscdi=true |