β-Adrenergic Receptors, Adenylate Cyclase Activity, and Cardiac Dysfunction in the Diabetic Rat
Cardiomyopathy is a complication of human diabetes mellitus. The relationship of cardiac function to the β-adrenergic receptor and catecholamine-stimulaled adenylate cyclase activity was investigated in the slreptozotocin-diabetic rat. β-Adrenergic receptor number in cardiac membranes from diabetic...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1985-01, Vol.7 (1), p.66-70 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Atkins, Floyd L Dowell, Russell T Love, Sandra |
| description | Cardiomyopathy is a complication of human diabetes mellitus. The relationship of cardiac function to the β-adrenergic receptor and catecholamine-stimulaled adenylate cyclase activity was investigated in the slreptozotocin-diabetic rat. β-Adrenergic receptor number in cardiac membranes from diabetic rats was reduced. After 2 weeks of diabetes, the response of adenylate cyclase to isoproterenol stimulation was not altered. Cardiac contractile function assessed by the maximum rate of rise of left ventricular pressure (I.V dP/dtmax) in an open-chest anesthetized rat was also unchanged from control at 2 weeks. However, after 4 weeks of diabetes, the sensitivity of adenylate cyclase to isoproterenol stimulation was depressed and abnormalities in cardiac contractility were noted, including a depressed response of I.V dP/dtmax to graded isoproterenol infusion. These studies suggest that alterations in β-adrenergic receptors and their coupling to adenylate cyclase may be important in the development of diabetic cardiomyopalhy. |
| doi_str_mv | 10.1097/00005344-198501000-00011 |
| format | Article |
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Apud cells (diseases) ; Endocrinopathies ; Heart - physiopathology ; Heart Rate ; Isoproterenol - pharmacology ; Male ; Medical sciences ; Myocardial Contraction ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, beta - analysis</subject><ispartof>Journal of cardiovascular pharmacology, 1985-01, Vol.7 (1), p.66-70</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4631-ff6a12190fd78c4b89edf9cc7a62eff6d6fc47c7017e4b4aacd5d27eee2f01d43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198501000-00011$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4010,4595,27900,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8446275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2580153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atkins, Floyd L</creatorcontrib><creatorcontrib>Dowell, Russell T</creatorcontrib><creatorcontrib>Love, Sandra</creatorcontrib><title>β-Adrenergic Receptors, Adenylate Cyclase Activity, and Cardiac Dysfunction in the Diabetic Rat</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Cardiomyopathy is a complication of human diabetes mellitus. The relationship of cardiac function to the β-adrenergic receptor and catecholamine-stimulaled adenylate cyclase activity was investigated in the slreptozotocin-diabetic rat. β-Adrenergic receptor number in cardiac membranes from diabetic rats was reduced. After 2 weeks of diabetes, the response of adenylate cyclase to isoproterenol stimulation was not altered. Cardiac contractile function assessed by the maximum rate of rise of left ventricular pressure (I.V dP/dtmax) in an open-chest anesthetized rat was also unchanged from control at 2 weeks. However, after 4 weeks of diabetes, the sensitivity of adenylate cyclase to isoproterenol stimulation was depressed and abnormalities in cardiac contractility were noted, including a depressed response of I.V dP/dtmax to graded isoproterenol infusion. These studies suggest that alterations in β-adrenergic receptors and their coupling to adenylate cyclase may be important in the development of diabetic cardiomyopalhy.</description><subject>Adenylyl Cyclases - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Heart - physiopathology</subject><subject>Heart Rate</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Contraction</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Adrenergic, beta - analysis</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdFqFDEUhkNR2rX6CEIuilcdTSaZyczlsm1VKAii1_FsctKNzc5sk0zLvJYP4jOZuuveGQgh_N85B75DCOXsPWe9-sDKaYSUFe-7hvHyq8rl_IQseCNEJVktXpAF4y2rainbM_IqpZ-FkI1qT8lp3XSsgAvy4_evamkjDhjvvKFf0eAujzFd0qXFYQ6Qka5mEyAhXZrsH32eLykMlq4gWg-GXs3JTUOJxoH6geYN0isPa8zP7SC_Ji8dhIRvDu85-X5z_W31qbr98vHzanlbGdkKXjnXAq95z5xVnZHrrkfremMUtDWW0LbOSGUU4wrlWgIY29haIWLtGLdSnJN3-767OD5MmLLe-mQwBBhwnJJWLRO94LyA3R40cUwpotO76LcQZ82Zfpar_8nVR7n6r9xS-vYwY1pv0R4LDzZLfnHIIRkILsJgfDpiXVlErZqCyT32NIaMMd2H6Qmj3iCEvNH_W634Awj3kjo</recordid><startdate>198501</startdate><enddate>198501</enddate><creator>Atkins, Floyd L</creator><creator>Dowell, Russell T</creator><creator>Love, Sandra</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198501</creationdate><title>β-Adrenergic Receptors, Adenylate Cyclase Activity, and Cardiac Dysfunction in the Diabetic Rat</title><author>Atkins, Floyd L ; Dowell, Russell T ; Love, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4631-ff6a12190fd78c4b89edf9cc7a62eff6d6fc47c7017e4b4aacd5d27eee2f01d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adenylyl Cyclases - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Heart - physiopathology</topic><topic>Heart Rate</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Contraction</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Adrenergic, beta - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atkins, Floyd L</creatorcontrib><creatorcontrib>Dowell, Russell T</creatorcontrib><creatorcontrib>Love, Sandra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atkins, Floyd L</au><au>Dowell, Russell T</au><au>Love, Sandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Adrenergic Receptors, Adenylate Cyclase Activity, and Cardiac Dysfunction in the Diabetic Rat</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1985-01</date><risdate>1985</risdate><volume>7</volume><issue>1</issue><spage>66</spage><epage>70</epage><pages>66-70</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>Cardiomyopathy is a complication of human diabetes mellitus. The relationship of cardiac function to the β-adrenergic receptor and catecholamine-stimulaled adenylate cyclase activity was investigated in the slreptozotocin-diabetic rat. β-Adrenergic receptor number in cardiac membranes from diabetic rats was reduced. After 2 weeks of diabetes, the response of adenylate cyclase to isoproterenol stimulation was not altered. Cardiac contractile function assessed by the maximum rate of rise of left ventricular pressure (I.V dP/dtmax) in an open-chest anesthetized rat was also unchanged from control at 2 weeks. However, after 4 weeks of diabetes, the sensitivity of adenylate cyclase to isoproterenol stimulation was depressed and abnormalities in cardiac contractility were noted, including a depressed response of I.V dP/dtmax to graded isoproterenol infusion. These studies suggest that alterations in β-adrenergic receptors and their coupling to adenylate cyclase may be important in the development of diabetic cardiomyopalhy.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2580153</pmid><doi>10.1097/00005344-198501000-00011</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 1985-01, Vol.7 (1), p.66-70 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76039311 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adenylyl Cyclases - analysis Animals Biological and medical sciences Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Heart - physiopathology Heart Rate Isoproterenol - pharmacology Male Medical sciences Myocardial Contraction Rats Rats, Inbred Strains Receptors, Adrenergic, beta - analysis |
| title | β-Adrenergic Receptors, Adenylate Cyclase Activity, and Cardiac Dysfunction in the Diabetic Rat |
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