Intracoronary Thallium-201 Assessment of Thrombolysis in Acute Myocardial Infarction Validation of the Method of Imaging Before and After Therapy
In order to study acute changes in perfusion with intracoronary thrombolytic therapy, we have used ten times the pretherapy intracoronary thallium-201 dose for the posttherapy study. Because of the larger posttherapy dose, the posttherapy images had ten times as many counts as the pretherapy images....
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| Veröffentlicht in: | Invest. Radiol.; (United States) 1985-01, Vol.20 (1), p.17-20 |
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| creator | PARKER, J ANTHONY HELLER, GARY V SILVERMAN, KENNETH J CAMPBELL, CHRIS C MARKIS, JOHN E ROYAL, HENRY D PAULIN, SVEN KOLODNY, GERALD M |
| description | In order to study acute changes in perfusion with intracoronary thrombolytic therapy, we have used ten times the pretherapy intracoronary thallium-201 dose for the posttherapy study. Because of the larger posttherapy dose, the posttherapy images had ten times as many counts as the pretherapy images. Since the change in image quality between the pretherapy and posttherapy studies might affect interpretation, we studied the effect of image statistics on interpretation of perfusion scintigraphy. The pretherapy and posttherapy images were scored on a four-point scale in five segments on each of three views. In 31 patients, Poisson-distributed pseudorandom noise was added to the posttherapy study in order to match the statistical accuracy of the pretherapy study. A blinded interpretation of the pretherapy and posttherapy noise-added images was performed in the same way as the initial unblinded interpretation. The mean difference between the unblinded pretherapy and posttherapy scores (the improvement in thallium distribution with therapy) was 2.5+/-0.8 (standard error) compared with the difference between the blinded pretherapy and posttherapy noise-added scores which was 2.6+/-1.0. The correlation between readings of similar pairs of data was higher than the correlation between pretherapy and posttherapy studies. Thus, the difference in statistic quality of the pretherapy and posttherapy studies did not affect the interpretation of these studies. Therefore, our evaluation of pretherapy and posttherapy studies using a ten-fold increase in thallium-201 dosage is valid. |
| doi_str_mv | 10.1097/00004424-198501000-00004 |
| format | Article |
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Dana Research Institute, Boston, MA</creatorcontrib><description>In order to study acute changes in perfusion with intracoronary thrombolytic therapy, we have used ten times the pretherapy intracoronary thallium-201 dose for the posttherapy study. Because of the larger posttherapy dose, the posttherapy images had ten times as many counts as the pretherapy images. Since the change in image quality between the pretherapy and posttherapy studies might affect interpretation, we studied the effect of image statistics on interpretation of perfusion scintigraphy. The pretherapy and posttherapy images were scored on a four-point scale in five segments on each of three views. In 31 patients, Poisson-distributed pseudorandom noise was added to the posttherapy study in order to match the statistical accuracy of the pretherapy study. A blinded interpretation of the pretherapy and posttherapy noise-added images was performed in the same way as the initial unblinded interpretation. The mean difference between the unblinded pretherapy and posttherapy scores (the improvement in thallium distribution with therapy) was 2.5+/-0.8 (standard error) compared with the difference between the blinded pretherapy and posttherapy noise-added scores which was 2.6+/-1.0. The correlation between readings of similar pairs of data was higher than the correlation between pretherapy and posttherapy studies. Thus, the difference in statistic quality of the pretherapy and posttherapy studies did not affect the interpretation of these studies. Therefore, our evaluation of pretherapy and posttherapy studies using a ten-fold increase in thallium-201 dosage is valid.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-198501000-00004</identifier><identifier>PMID: 3980175</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; 550603 - Medicine- External Radiation in Therapy- (1980-) ; BETA DECAY RADIOISOTOPES ; BODY ; CARDIOVASCULAR DISEASES ; Coronary Vessels ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DOSES ; ELECTRON CAPTURE RADIOISOTOPES ; EVALUATION ; HEAVY NUCLEI ; Humans ; Injections, Intra-Arterial ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; MEDICINE ; MYOCARDIAL INFARCTION ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - drug therapy ; NOISE ; NUCLEAR MEDICINE ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; PERFUSED ORGANS ; RADIATION DOSES ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; RADIOTHERAPY ; SCINTISCANNING ; SECONDS LIVING RADIOISOTOPES ; Streptokinase - administration & dosage ; Streptokinase - therapeutic use ; Thallium ; THALLIUM 201 ; THALLIUM ISOTOPES ; THERAPY ; Time Factors</subject><ispartof>Invest. Radiol.; (United States), 1985-01, Vol.20 (1), p.17-20</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2974-fcd8bbe79aa2213d86e778a1ef7e1c517fc6ad1e4ef28e4cc23739d84b4b276f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3980175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5568485$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>PARKER, J ANTHONY</creatorcontrib><creatorcontrib>HELLER, GARY V</creatorcontrib><creatorcontrib>SILVERMAN, KENNETH J</creatorcontrib><creatorcontrib>CAMPBELL, CHRIS C</creatorcontrib><creatorcontrib>MARKIS, JOHN E</creatorcontrib><creatorcontrib>ROYAL, HENRY D</creatorcontrib><creatorcontrib>PAULIN, SVEN</creatorcontrib><creatorcontrib>KOLODNY, GERALD M</creatorcontrib><creatorcontrib>Charles A. Dana Research Institute, Boston, MA</creatorcontrib><title>Intracoronary Thallium-201 Assessment of Thrombolysis in Acute Myocardial Infarction Validation of the Method of Imaging Before and After Therapy</title><title>Invest. Radiol.; (United States)</title><addtitle>Invest Radiol</addtitle><description>In order to study acute changes in perfusion with intracoronary thrombolytic therapy, we have used ten times the pretherapy intracoronary thallium-201 dose for the posttherapy study. Because of the larger posttherapy dose, the posttherapy images had ten times as many counts as the pretherapy images. Since the change in image quality between the pretherapy and posttherapy studies might affect interpretation, we studied the effect of image statistics on interpretation of perfusion scintigraphy. The pretherapy and posttherapy images were scored on a four-point scale in five segments on each of three views. In 31 patients, Poisson-distributed pseudorandom noise was added to the posttherapy study in order to match the statistical accuracy of the pretherapy study. A blinded interpretation of the pretherapy and posttherapy noise-added images was performed in the same way as the initial unblinded interpretation. The mean difference between the unblinded pretherapy and posttherapy scores (the improvement in thallium distribution with therapy) was 2.5+/-0.8 (standard error) compared with the difference between the blinded pretherapy and posttherapy noise-added scores which was 2.6+/-1.0. The correlation between readings of similar pairs of data was higher than the correlation between pretherapy and posttherapy studies. Thus, the difference in statistic quality of the pretherapy and posttherapy studies did not affect the interpretation of these studies. Therefore, our evaluation of pretherapy and posttherapy studies using a ten-fold increase in thallium-201 dosage is valid.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BODY</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>Coronary Vessels</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DOSES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>EVALUATION</subject><subject>HEAVY NUCLEI</subject><subject>Humans</subject><subject>Injections, Intra-Arterial</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>MEDICINE</subject><subject>MYOCARDIAL INFARCTION</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - drug therapy</subject><subject>NOISE</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PERFUSED ORGANS</subject><subject>RADIATION DOSES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>RADIOTHERAPY</subject><subject>SCINTISCANNING</subject><subject>SECONDS LIVING RADIOISOTOPES</subject><subject>Streptokinase - administration & dosage</subject><subject>Streptokinase - therapeutic use</subject><subject>Thallium</subject><subject>THALLIUM 201</subject><subject>THALLIUM ISOTOPES</subject><subject>THERAPY</subject><subject>Time Factors</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks-OFCEQxjtGs46rj2BCPHhrBZpu4Dhu_DPJGi-rV0LTxTZKwwh0NvMYvrHs9rg3uUBV_b6qpD6aBhH8jmDJ3-N6GKOsJVL0mNSofUg9aXak74YWU4KfNjuMKW6llMPz5kXOPytBOe4umotOCkx4v2v-HEJJ2sQUg04ndDNr7926tBQTtM8Zcl4gFBRtLaW4jNGfssvIBbQ3awH09RSNTpPTHh2C1ckUFwP6ob2b9MOzKstcOShznO6jw6JvXbhFH8DGBEiHCe1tgVQHQNLH08vmmdU-w6vzfdl8__Tx5upLe_3t8-Fqf90aKjlrrZnEOAKXWlNKukkMwLnQBCwHYnrCrRn0RICBpQKYMbTjnZwEG9lI-WC7y-bN1jfm4lQ2roCZTQwBTFF9Pwgm-gq93aBjir9XyEUtLhvwXgeIa1Z8wJ2Qnaig2ECTYs4JrDomt9SVKoLVvWXqn2Xq0bItVaWvzzPWcYHpUXj2qNbZVr-Lvu4p__LrHSQ1g_ZlVv_7Cd1fyP6isg</recordid><startdate>198501</startdate><enddate>198501</enddate><creator>PARKER, J ANTHONY</creator><creator>HELLER, GARY V</creator><creator>SILVERMAN, KENNETH J</creator><creator>CAMPBELL, CHRIS C</creator><creator>MARKIS, JOHN E</creator><creator>ROYAL, HENRY D</creator><creator>PAULIN, SVEN</creator><creator>KOLODNY, GERALD M</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198501</creationdate><title>Intracoronary Thallium-201 Assessment of Thrombolysis in Acute Myocardial Infarction Validation of the Method of Imaging Before and After Therapy</title><author>PARKER, J ANTHONY ; HELLER, GARY V ; SILVERMAN, KENNETH J ; CAMPBELL, CHRIS C ; MARKIS, JOHN E ; ROYAL, HENRY D ; PAULIN, SVEN ; KOLODNY, GERALD M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2974-fcd8bbe79aa2213d86e778a1ef7e1c517fc6ad1e4ef28e4cc23739d84b4b276f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BODY</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>Coronary Vessels</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>DOSES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>EVALUATION</topic><topic>HEAVY NUCLEI</topic><topic>Humans</topic><topic>Injections, Intra-Arterial</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>MEDICINE</topic><topic>MYOCARDIAL INFARCTION</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - drug therapy</topic><topic>NOISE</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PERFUSED ORGANS</topic><topic>RADIATION DOSES</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>RADIOTHERAPY</topic><topic>SCINTISCANNING</topic><topic>SECONDS LIVING RADIOISOTOPES</topic><topic>Streptokinase - administration & dosage</topic><topic>Streptokinase - therapeutic use</topic><topic>Thallium</topic><topic>THALLIUM 201</topic><topic>THALLIUM ISOTOPES</topic><topic>THERAPY</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PARKER, J ANTHONY</creatorcontrib><creatorcontrib>HELLER, GARY V</creatorcontrib><creatorcontrib>SILVERMAN, KENNETH J</creatorcontrib><creatorcontrib>CAMPBELL, CHRIS C</creatorcontrib><creatorcontrib>MARKIS, JOHN E</creatorcontrib><creatorcontrib>ROYAL, HENRY D</creatorcontrib><creatorcontrib>PAULIN, SVEN</creatorcontrib><creatorcontrib>KOLODNY, GERALD M</creatorcontrib><creatorcontrib>Charles A. Dana Research Institute, Boston, MA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Invest. Radiol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PARKER, J ANTHONY</au><au>HELLER, GARY V</au><au>SILVERMAN, KENNETH J</au><au>CAMPBELL, CHRIS C</au><au>MARKIS, JOHN E</au><au>ROYAL, HENRY D</au><au>PAULIN, SVEN</au><au>KOLODNY, GERALD M</au><aucorp>Charles A. Dana Research Institute, Boston, MA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracoronary Thallium-201 Assessment of Thrombolysis in Acute Myocardial Infarction Validation of the Method of Imaging Before and After Therapy</atitle><jtitle>Invest. Radiol.; (United States)</jtitle><addtitle>Invest Radiol</addtitle><date>1985-01</date><risdate>1985</risdate><volume>20</volume><issue>1</issue><spage>17</spage><epage>20</epage><pages>17-20</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>In order to study acute changes in perfusion with intracoronary thrombolytic therapy, we have used ten times the pretherapy intracoronary thallium-201 dose for the posttherapy study. Because of the larger posttherapy dose, the posttherapy images had ten times as many counts as the pretherapy images. Since the change in image quality between the pretherapy and posttherapy studies might affect interpretation, we studied the effect of image statistics on interpretation of perfusion scintigraphy. The pretherapy and posttherapy images were scored on a four-point scale in five segments on each of three views. In 31 patients, Poisson-distributed pseudorandom noise was added to the posttherapy study in order to match the statistical accuracy of the pretherapy study. A blinded interpretation of the pretherapy and posttherapy noise-added images was performed in the same way as the initial unblinded interpretation. The mean difference between the unblinded pretherapy and posttherapy scores (the improvement in thallium distribution with therapy) was 2.5+/-0.8 (standard error) compared with the difference between the blinded pretherapy and posttherapy noise-added scores which was 2.6+/-1.0. The correlation between readings of similar pairs of data was higher than the correlation between pretherapy and posttherapy studies. Thus, the difference in statistic quality of the pretherapy and posttherapy studies did not affect the interpretation of these studies. Therefore, our evaluation of pretherapy and posttherapy studies using a ten-fold increase in thallium-201 dosage is valid.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>3980175</pmid><doi>10.1097/00004424-198501000-00004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-9996 |
| ispartof | Invest. Radiol.; (United States), 1985-01, Vol.20 (1), p.17-20 |
| issn | 0020-9996 1536-0210 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76038938 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics 550603 - Medicine- External Radiation in Therapy- (1980-) BETA DECAY RADIOISOTOPES BODY CARDIOVASCULAR DISEASES Coronary Vessels COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSTIC TECHNIQUES DISEASES DOSES ELECTRON CAPTURE RADIOISOTOPES EVALUATION HEAVY NUCLEI Humans Injections, Intra-Arterial ISOMERIC TRANSITION ISOTOPES ISOTOPES MEDICINE MYOCARDIAL INFARCTION Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy NOISE NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PERFUSED ORGANS RADIATION DOSES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging RADIOTHERAPY SCINTISCANNING SECONDS LIVING RADIOISOTOPES Streptokinase - administration & dosage Streptokinase - therapeutic use Thallium THALLIUM 201 THALLIUM ISOTOPES THERAPY Time Factors |
| title | Intracoronary Thallium-201 Assessment of Thrombolysis in Acute Myocardial Infarction Validation of the Method of Imaging Before and After Therapy |
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