HIV-1 reverse transcriptase: Inhibition by 2',5'-oligoadenylates

2',5'-Oligoadenylates (2-5A) and derivatives are noncompetitive inhibitors of primer/HIV-1 reverse transcriptase complex formation. The mechanism and specificity of this inhibitory action of 2-5A and 2-5A derivatives have been evaluated with 2-5A molecules modified in ribosyl moiety, chain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 1993-11, Vol.32 (45), p.12112-12118
Hauptverfasser:	Sobol, Robert W, Fisher, William L, Reichenbach, Nancy L, Kumar, Amalendra, Beard, William A, Wilson, Samuel H, Charubala, Ramamurthy, Pfleiderer, Wolfgang, Suhadolnik, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - pharmacology AIDS/HIV Analytical, structural and metabolic biochemistry Antiviral Agents - pharmacology Biological and medical sciences DNA - biosynthesis DNA - drug effects Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology HIV Reverse Transcriptase HIV-1 - enzymology human immunodeficiency virus 1 Hydrolases Oligoribonucleotides - pharmacology Phosphorylation Photochemistry Reverse Transcriptase Inhibitors Thymidine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!