Bötzinger expiratory neurones inhibit propriobulbar decrementing inspiratory neurones
ALTHOUGH bulbospinal, expiratory neurones of the Bötzinger complex (BOT E-AUG) are known to have monosynaptic inhibitory connections to many bulbospinal respiratory neurones, their connections to propriobulbar respiratory neurones have not been so well characterized. We stimulated BOT E-AUG neurones...
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| Veröffentlicht in: | Neuroreport 1993-09, Vol.4 (11), p.1215-1218 |
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| creator | Duffin, James Douse, Mark A |
| description | ALTHOUGH bulbospinal, expiratory neurones of the Bötzinger complex (BOT E-AUG) are known to have monosynaptic inhibitory connections to many bulbospinal respiratory neurones, their connections to propriobulbar respiratory neurones have not been so well characterized. We stimulated BOT E-AUG neurones with trains of pulses, and found an inhibition of medullary and phrenic respiratory activity with phase resetting. We also examined the response of propriobulbar, decrementing, inspiratory neurones (I-DEC) to the antidromic activation of BOT E-AUG neurones from the C3 segment of the spinal cord with single shocks and found evidence for a monosynaptic inhibition of the I-DEC neurones in the post-stimulus histograms of the extracellular firing. These results were obtained in 11 pentobarbital anaesthetized cats, and provide experimental support for a recent model of respiratory rhythmogenesis. |
| doi_str_mv | 10.1097/00001756-199309000-00001 |
| format | Article |
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Vestibular system and equilibration</subject><subject>Motor Neurons - physiology</subject><subject>Neurons - physiology</subject><subject>Phrenic Nerve - physiology</subject><subject>Respiration - physiology</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - physiology</subject><subject>Synapses - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kclOwzAQhi0EKmV5BKQcELeAHe9HQGxSJS6AuFkTd0oDaVLsRCwPxgvwYhhaekH4MvbM94_HvwnJGD1k1OojmhbTUuXMWk5tOuU_qTUyZELzXEpzv06G1EqbC6vkJtmK8TERljIzIANTsLRTQ3J38vnRvVfNA4YMX-dVgK4Nb1mDfWgbjFnVTKuy6rJ5aOehasu-LiFkY_QBZ9h0SZiQ-Ee3QzYmUEfcXcZtcnt-dnN6mY-uL65Oj0e5L6xmOSt4aTyAoLIUDMa0ANBjqRgF4SdAldDKlr4QTAvPjVJaKAacykIyKJHxbXKw6Jvme-4xdm5WRY91DQ22fXRaUc6NsQk0C9CHNsaAE5eeM4Pw5hh135a6X0vdytJFKkn3lnf05QzHK-HSw1TfX9YheqgnARpfxRUmjOFGf7cRC-ylrTsM8anuXzC4KULdTd1_H8q_ADuQj9c</recordid><startdate>19930910</startdate><enddate>19930910</enddate><creator>Duffin, James</creator><creator>Douse, Mark A</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930910</creationdate><title>Bötzinger expiratory neurones inhibit propriobulbar decrementing inspiratory neurones</title><author>Duffin, James ; Douse, Mark A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2971-123b8caa405b41ad02aa7d5610a4cfa064769bc24174c38667461a305251abe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Electric Stimulation</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medulla Oblongata - cytology</topic><topic>Medulla Oblongata - physiology</topic><topic>Microelectrodes</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Motor Neurons - physiology</topic><topic>Neurons - physiology</topic><topic>Phrenic Nerve - physiology</topic><topic>Respiration - physiology</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - physiology</topic><topic>Synapses - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duffin, James</creatorcontrib><creatorcontrib>Douse, Mark A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duffin, James</au><au>Douse, Mark A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bötzinger expiratory neurones inhibit propriobulbar decrementing inspiratory neurones</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1993-09-10</date><risdate>1993</risdate><volume>4</volume><issue>11</issue><spage>1215</spage><epage>1218</epage><pages>1215-1218</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>ALTHOUGH bulbospinal, expiratory neurones of the Bötzinger complex (BOT E-AUG) are known to have monosynaptic inhibitory connections to many bulbospinal respiratory neurones, their connections to propriobulbar respiratory neurones have not been so well characterized. We stimulated BOT E-AUG neurones with trains of pulses, and found an inhibition of medullary and phrenic respiratory activity with phase resetting. We also examined the response of propriobulbar, decrementing, inspiratory neurones (I-DEC) to the antidromic activation of BOT E-AUG neurones from the C3 segment of the spinal cord with single shocks and found evidence for a monosynaptic inhibition of the I-DEC neurones in the post-stimulus histograms of the extracellular firing. These results were obtained in 11 pentobarbital anaesthetized cats, and provide experimental support for a recent model of respiratory rhythmogenesis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8219016</pmid><doi>10.1097/00001756-199309000-00001</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cats Electric Stimulation Evoked Potentials - physiology Female Fundamental and applied biological sciences. Psychology Male Medulla Oblongata - cytology Medulla Oblongata - physiology Microelectrodes Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Neurons - physiology Neurons - physiology Phrenic Nerve - physiology Respiration - physiology Spinal Cord - cytology Spinal Cord - physiology Synapses - physiology Vertebrates: nervous system and sense organs |
| title | Bötzinger expiratory neurones inhibit propriobulbar decrementing inspiratory neurones |
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