Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors
1,3-Dihydroxy-2-methylxanthone (X1), its 4-chloro and 4-bromo derivatives (X1-Cl and X1-Br), and 1,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be rev...
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| Veröffentlicht in: | Pharmaceutical research 1993-08, Vol.10 (8), p.1187-1190 |
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| container_title | Pharmaceutical research |
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| creator | THULL, U KNEUBÜHLER, S TESTA, B BORGES, M. F. M PINTO, M. M. M |
| description | 1,3-Dihydroxy-2-methylxanthone (X1), its 4-chloro and 4-bromo derivatives (X1-Cl and X1-Br), and 1,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be reversible and selective inhibitors of MAO-A, with X1 displaying the highest activity (IC50 = 3.7 microM). |
| doi_str_mv | 10.1023/A:1018924503552 |
| format | Article |
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Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Xanthines - chemical synthesis</topic><topic>Xanthines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THULL, U</creatorcontrib><creatorcontrib>KNEUBÜHLER, S</creatorcontrib><creatorcontrib>TESTA, B</creatorcontrib><creatorcontrib>BORGES, M. F. M</creatorcontrib><creatorcontrib>PINTO, M. M. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>10</volume><issue>8</issue><spage>1187</spage><epage>1190</epage><pages>1187-1190</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>1,3-Dihydroxy-2-methylxanthone (X1), its 4-chloro and 4-bromo derivatives (X1-Cl and X1-Br), and 1,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. 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| ispartof | Pharmaceutical research, 1993-08, Vol.10 (8), p.1187-1190 |
| issn | 0724-8741 1573-904X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Brain - ultrastructure Brain Chemistry - drug effects In Vitro Techniques Kinetics Medical sciences Mitochondria - drug effects Mitochondria - enzymology Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - pharmacology Nerve Tissue Proteins - metabolism Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Xanthines - chemical synthesis Xanthines - pharmacology |
| title | Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors |
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