Inhibition of canine gastric secretion by the prostanoid Ro 22-6923
The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited...
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| Veröffentlicht in: | Digestive diseases and sciences 1985-04, Vol.30 (4), p.340-345 |
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| container_title | Digestive diseases and sciences |
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| creator | GAGINELLA, T. S BERTKO, R. J MULLER, R. K. M GALLO-TORRES, H SULLIVAN, A. C |
| description | The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated acid secretion at an oral dose of 0.5 mg/kg. The effect lasted for 4 hr and was of greater intensity than that observed with 5 mg/kg cimetidine. The ED50 for Ro 22-6923 in this model was 0.25 mg/kg and 0.09 mg/kg for oral and intrapouch administration, respectively. Natural prostaglandin E2 was inactive up to 1 mg/kg orally, but had an ED50 of 0.08 mg/kg when administered directly into the pouch. The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man. |
| doi_str_mv | 10.1007/BF01403843 |
| format | Article |
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The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF01403843</identifier><identifier>PMID: 3979240</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Anti-Ulcer Agents - pharmacology ; Applied sciences ; Cimetidine - pharmacology ; Dogs ; Dose-Response Relationship, Drug ; Exact sciences and technology ; Female ; Gastrectomy ; Gastric Acid - metabolism ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Male ; Other techniques and industries ; Prostaglandins E, Synthetic - pharmacology ; Time Factors</subject><ispartof>Digestive diseases and sciences, 1985-04, Vol.30 (4), p.340-345</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-bb9e81a92d1ff27891ad99e96779ceaaa61ed1aa6625679607cbd92e530cca613</citedby><cites>FETCH-LOGICAL-c311t-bb9e81a92d1ff27891ad99e96779ceaaa61ed1aa6625679607cbd92e530cca613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8836973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3979240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GAGINELLA, T. 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Natural prostaglandin E2 was inactive up to 1 mg/kg orally, but had an ED50 of 0.08 mg/kg when administered directly into the pouch. The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Applied sciences</subject><subject>Cimetidine - pharmacology</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Male</subject><subject>Other techniques and industries</subject><subject>Prostaglandins E, Synthetic - pharmacology</subject><subject>Time Factors</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oUcxINQfS_Zkuaow-lgIIieS5q-ukjXzqY97L83ujJP78Hvx8fHx9glwh0C6PvHBeAUZDqVR2yMMy0TMVPpMRsDqvgjqlN2FsIXABiNasRG0mgjpjBm82W99rnvfFPzpuTO1r4m_mlD13rHA7mW_li-492a-LZtQmfrxhf8reFCJMoIec5OSlsFuhjuhH0snt7nL8nq9Xk5f1glTiJ2SZ4bStEaUWBZCp0atIUxZJTWxpG1ViEVGI-K7bVRoF1eGEEzCc5FKCfsZp8bW3z3FLps44OjqrI1NX3ItAIJSpko3u5FF-uGlsps2_qNbXcZQva7WPa_WJSvhtQ-31BxUIeJIr8euA3OVmVra-fDQUtTqYyW8gdqeHB5</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>GAGINELLA, T. 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J</creatorcontrib><creatorcontrib>MULLER, R. K. M</creatorcontrib><creatorcontrib>GALLO-TORRES, H</creatorcontrib><creatorcontrib>SULLIVAN, A. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GAGINELLA, T. S</au><au>BERTKO, R. J</au><au>MULLER, R. K. M</au><au>GALLO-TORRES, H</au><au>SULLIVAN, A. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of canine gastric secretion by the prostanoid Ro 22-6923</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1985-04</date><risdate>1985</risdate><volume>30</volume><issue>4</issue><spage>340</spage><epage>345</epage><pages>340-345</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated acid secretion at an oral dose of 0.5 mg/kg. The effect lasted for 4 hr and was of greater intensity than that observed with 5 mg/kg cimetidine. The ED50 for Ro 22-6923 in this model was 0.25 mg/kg and 0.09 mg/kg for oral and intrapouch administration, respectively. Natural prostaglandin E2 was inactive up to 1 mg/kg orally, but had an ED50 of 0.08 mg/kg when administered directly into the pouch. The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3979240</pmid><doi>10.1007/BF01403843</doi><tpages>6</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 1985-04, Vol.30 (4), p.340-345 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Anti-Ulcer Agents - pharmacology Applied sciences Cimetidine - pharmacology Dogs Dose-Response Relationship, Drug Exact sciences and technology Female Gastrectomy Gastric Acid - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism Male Other techniques and industries Prostaglandins E, Synthetic - pharmacology Time Factors |
| title | Inhibition of canine gastric secretion by the prostanoid Ro 22-6923 |
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