Allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions

The allosteric behavior of the Co(II)-substituted insulin hexamer has been investigated using electronic spectroscopy to study the binding of different phenolic analogues and singly charged anions to effector sites on the protein. This work presents the first detailed, quantitative analysis of the l...

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Veröffentlicht in:	Biochemistry (Easton) 1993-11, Vol.32 (43), p.11638-11645
Hauptverfasser:	Choi, Wonjae E., Brader, Mark L., Aguilar, Valentin, Kaarsholm, Niels C., Dunn, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Biological and medical sciences Biopolymers Cobalt Fundamental and applied biological sciences. Psychology Humans Insulin - chemistry Insulin - metabolism Interactions. Associations Intermolecular phenomena Ligands Models, Chemical Molecular biophysics Protein Conformation
Online-Zugang:	Volltext
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