Conformational states of Leu5- and Met5-enkephalins in solution
The molecular conformations of Leu5- and Met5-enkephalins in aqueous and DMSO solutions were investigated by FT-IR and laser Raman spectroscopic methods. The amide I, II, and III regions in the FT-IR spectra of Leu5- and Met5-enkephalins in aqueous solution were analyzed by performing Fourier self-d...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1985-02, Vol.126 (3), p.1029-1035 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 126 |
| creator | RENUGAOPALAKRISHNAN, V RAPAKA, R. S COLETTE, T. W CARREIRA, L. A BHATNAGAR, R. S |
| description | The molecular conformations of Leu5- and Met5-enkephalins in aqueous and DMSO solutions were investigated by FT-IR and laser Raman spectroscopic methods. The amide I, II, and III regions in the FT-IR spectra of Leu5- and Met5-enkephalins in aqueous solution were analyzed by performing Fourier self-deconvolution of the bands. Leu5-enkephalin in aqueous solution is found to exist in both type II beta-turn and beta-sheet structures, whereas Met5-enkephalin has a lesser tendency to form beta-turn structure in aqueous solution. It is likely that these different conformers of enkephalins might bind to different receptor types. |
| doi_str_mv | 10.1016/0006-291X(85)90288-8 |
| format | Article |
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Leu5-enkephalin in aqueous solution is found to exist in both type II beta-turn and beta-sheet structures, whereas Met5-enkephalin has a lesser tendency to form beta-turn structure in aqueous solution. It is likely that these different conformers of enkephalins might bind to different receptor types.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>3977900</pmid><doi>10.1016/0006-291X(85)90288-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1985-02, Vol.126 (3), p.1029-1035 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Applied sciences Chemical Phenomena Chemistry Enkephalin, Leucine Enkephalin, Methionine Exact sciences and technology Fourier Analysis Other techniques and industries Protein Conformation Solutions Spectrophotometry, Infrared Spectrum Analysis, Raman |
| title | Conformational states of Leu5- and Met5-enkephalins in solution |
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