Negative autoregulation by Ultrabithorax controls the level and pattern of its expression
The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and abdominal segmental identities. Ubx autoregulation was examined by manipulating UBX levels, both genetically and with an inducible transgene, and monitoring the effect of thes...
Gespeichert in:
| Veröffentlicht in: | Development (Cambridge) 1993-01, Vol.117 (1), p.387-399 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 399 |
|---|---|
| container_issue | 1 |
| container_start_page | 387 |
| container_title | Development (Cambridge) |
| container_volume | 117 |
| creator | IRVINE, K. D BOTAS, J SANJAYA JHA MANN, R. S HOGNESS, D. S |
| description | The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and abdominal segmental identities. Ubx autoregulation was examined by manipulating UBX levels, both genetically and with an inducible transgene, and monitoring the effect of these manipulations on the expression of Ubx and Ubx-lacZ reporter genes. Positive autoregulation by Ubx is restricted to the visceral mesoderm, while in other tissues Ubx negatively autoregulates. In some cases, negative autoregulation stabilizes UBX levels, while in others it modulates the spatial and temporal patterns of UBX expression. This modulation of UBX expression may enable Ubx to specify distinct identities in different segments. The upstream control region of Ubx contains multiple autoregulatory elements for both positive and negative autoregulation. |
| doi_str_mv | 10.1242/dev.117.1.387 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76025278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16646581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-fcbfa84065f3441fd022a519ef2a97a58e8756183c7c651a836841e1a10c3d083</originalsourceid><addsrcrecordid>eNqFkEuLFDEUhYMoYzu6dClkIa6sNjdVeS1lGB8w6MZZuAqp1K3uSLpSJql25t9bQzeDO1eXy_k4Bz5CXgPbAu_4hwGPWwC1hW2r1ROygU6pxgA3T8mGGcEaMAaekxel_GKMtVKpC3KhDGNG6w35-Q13roYjUrfUlHG3xPVNE-3v6W2s2fWh7lN2d9SnqeYUC617pBGPGKmbBjq7WjFPNI001ELxbs5YytrwkjwbXSz46nwvye2n6x9XX5qb75-_Xn28aXyrRW1G349Od0yKse06GAfGuRNgcOTOKCc0aiUk6NYrLwU43UrdAYID5tuB6faSvDv1zjn9XrBUewjFY4xuwrQUqyTjgqv_gyBlJ4WGFWxOoM-plIyjnXM4uHxvgdkH53Z1blfnFuzqfOXfnIuX_oDDI32WvOZvz7kr3sUxu8mH8oh1QrWG8RV7f8L2Ybf_EzLaPqSYdqHU8rCIMc3_rP4FO9OaHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16646581</pqid></control><display><type>article</type><title>Negative autoregulation by Ultrabithorax controls the level and pattern of its expression</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>IRVINE, K. D ; BOTAS, J ; SANJAYA JHA ; MANN, R. S ; HOGNESS, D. S</creator><creatorcontrib>IRVINE, K. D ; BOTAS, J ; SANJAYA JHA ; MANN, R. S ; HOGNESS, D. S</creatorcontrib><description>The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and abdominal segmental identities. Ubx autoregulation was examined by manipulating UBX levels, both genetically and with an inducible transgene, and monitoring the effect of these manipulations on the expression of Ubx and Ubx-lacZ reporter genes. Positive autoregulation by Ubx is restricted to the visceral mesoderm, while in other tissues Ubx negatively autoregulates. In some cases, negative autoregulation stabilizes UBX levels, while in others it modulates the spatial and temporal patterns of UBX expression. This modulation of UBX expression may enable Ubx to specify distinct identities in different segments. The upstream control region of Ubx contains multiple autoregulatory elements for both positive and negative autoregulation.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.117.1.387</identifier><identifier>PMID: 7900988</identifier><language>eng</language><publisher>Cambridge: The Company of Biologists Limited</publisher><subject>Animals ; Biological and medical sciences ; DNA-Binding Proteins - genetics ; Drosophila ; Drosophila - embryology ; Drosophila - genetics ; Drosophila Proteins ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - genetics ; Genes, Homeobox - genetics ; Homeodomain Proteins ; In Situ Hybridization ; Insecta ; Invertebrates ; Life cycle. Embryology. Development ; Morphogenesis - genetics ; Physiology. Development ; Transcription Factors</subject><ispartof>Development (Cambridge), 1993-01, Vol.117 (1), p.387-399</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-fcbfa84065f3441fd022a519ef2a97a58e8756183c7c651a836841e1a10c3d083</citedby><cites>FETCH-LOGICAL-c385t-fcbfa84065f3441fd022a519ef2a97a58e8756183c7c651a836841e1a10c3d083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3665,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4573902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7900988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IRVINE, K. D</creatorcontrib><creatorcontrib>BOTAS, J</creatorcontrib><creatorcontrib>SANJAYA JHA</creatorcontrib><creatorcontrib>MANN, R. S</creatorcontrib><creatorcontrib>HOGNESS, D. S</creatorcontrib><title>Negative autoregulation by Ultrabithorax controls the level and pattern of its expression</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and abdominal segmental identities. Ubx autoregulation was examined by manipulating UBX levels, both genetically and with an inducible transgene, and monitoring the effect of these manipulations on the expression of Ubx and Ubx-lacZ reporter genes. Positive autoregulation by Ubx is restricted to the visceral mesoderm, while in other tissues Ubx negatively autoregulates. In some cases, negative autoregulation stabilizes UBX levels, while in others it modulates the spatial and temporal patterns of UBX expression. This modulation of UBX expression may enable Ubx to specify distinct identities in different segments. The upstream control region of Ubx contains multiple autoregulatory elements for both positive and negative autoregulation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - genetics</subject><subject>Genes, Homeobox - genetics</subject><subject>Homeodomain Proteins</subject><subject>In Situ Hybridization</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>Life cycle. Embryology. Development</subject><subject>Morphogenesis - genetics</subject><subject>Physiology. Development</subject><subject>Transcription Factors</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEUhYMoYzu6dClkIa6sNjdVeS1lGB8w6MZZuAqp1K3uSLpSJql25t9bQzeDO1eXy_k4Bz5CXgPbAu_4hwGPWwC1hW2r1ROygU6pxgA3T8mGGcEaMAaekxel_GKMtVKpC3KhDGNG6w35-Q13roYjUrfUlHG3xPVNE-3v6W2s2fWh7lN2d9SnqeYUC617pBGPGKmbBjq7WjFPNI001ELxbs5YytrwkjwbXSz46nwvye2n6x9XX5qb75-_Xn28aXyrRW1G349Od0yKse06GAfGuRNgcOTOKCc0aiUk6NYrLwU43UrdAYID5tuB6faSvDv1zjn9XrBUewjFY4xuwrQUqyTjgqv_gyBlJ4WGFWxOoM-plIyjnXM4uHxvgdkH53Z1blfnFuzqfOXfnIuX_oDDI32WvOZvz7kr3sUxu8mH8oh1QrWG8RV7f8L2Ybf_EzLaPqSYdqHU8rCIMc3_rP4FO9OaHQ</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>IRVINE, K. D</creator><creator>BOTAS, J</creator><creator>SANJAYA JHA</creator><creator>MANN, R. S</creator><creator>HOGNESS, D. S</creator><general>The Company of Biologists Limited</general><general>Company of Biologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19930101</creationdate><title>Negative autoregulation by Ultrabithorax controls the level and pattern of its expression</title><author>IRVINE, K. D ; BOTAS, J ; SANJAYA JHA ; MANN, R. S ; HOGNESS, D. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-fcbfa84065f3441fd022a519ef2a97a58e8756183c7c651a836841e1a10c3d083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - genetics</topic><topic>Genes, Homeobox - genetics</topic><topic>Homeodomain Proteins</topic><topic>In Situ Hybridization</topic><topic>Insecta</topic><topic>Invertebrates</topic><topic>Life cycle. Embryology. Development</topic><topic>Morphogenesis - genetics</topic><topic>Physiology. Development</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IRVINE, K. D</creatorcontrib><creatorcontrib>BOTAS, J</creatorcontrib><creatorcontrib>SANJAYA JHA</creatorcontrib><creatorcontrib>MANN, R. S</creatorcontrib><creatorcontrib>HOGNESS, D. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IRVINE, K. D</au><au>BOTAS, J</au><au>SANJAYA JHA</au><au>MANN, R. S</au><au>HOGNESS, D. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative autoregulation by Ultrabithorax controls the level and pattern of its expression</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1993-01-01</date><risdate>1993</risdate><volume>117</volume><issue>1</issue><spage>387</spage><epage>399</epage><pages>387-399</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and abdominal segmental identities. Ubx autoregulation was examined by manipulating UBX levels, both genetically and with an inducible transgene, and monitoring the effect of these manipulations on the expression of Ubx and Ubx-lacZ reporter genes. Positive autoregulation by Ubx is restricted to the visceral mesoderm, while in other tissues Ubx negatively autoregulates. In some cases, negative autoregulation stabilizes UBX levels, while in others it modulates the spatial and temporal patterns of UBX expression. This modulation of UBX expression may enable Ubx to specify distinct identities in different segments. The upstream control region of Ubx contains multiple autoregulatory elements for both positive and negative autoregulation.</abstract><cop>Cambridge</cop><pub>The Company of Biologists Limited</pub><pmid>7900988</pmid><doi>10.1242/dev.117.1.387</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1993-01, Vol.117 (1), p.387-399 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76025278 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Biological and medical sciences DNA-Binding Proteins - genetics Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Genes, Homeobox - genetics Homeodomain Proteins In Situ Hybridization Insecta Invertebrates Life cycle. Embryology. Development Morphogenesis - genetics Physiology. Development Transcription Factors |
| title | Negative autoregulation by Ultrabithorax controls the level and pattern of its expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T18%3A04%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Negative%20autoregulation%20by%20Ultrabithorax%20controls%20the%20level%20and%20pattern%20of%20its%20expression&rft.jtitle=Development%20(Cambridge)&rft.au=IRVINE,%20K.%20D&rft.date=1993-01-01&rft.volume=117&rft.issue=1&rft.spage=387&rft.epage=399&rft.pages=387-399&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.117.1.387&rft_dat=%3Cproquest_cross%3E16646581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16646581&rft_id=info:pmid/7900988&rfr_iscdi=true |